Category: 2698-41-1

Some common heterocyclic compound, 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, molecular formula is C10H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2698-41-1

General procedure: To a stirred mixture of aromatic aldehyde (2.0 mmol) and malononitrile (2.0 mmol) in ethanol (10 ml), a catalytic amount of DMA (5 mol%) was added at room temperature. To the precipitated solid materials, ethanolic solution of dimedone orethyl acetoacetate or barbituric acid (2.0 mmol) was added and from the resultingsolution, the products get precipitated within the time mentioned in Tables 1, 2, 3,and 4. For 4H-benzo[h]chromenes, 1-naphthol (2.0 mmol) was added to the arylidenemalononitrile and stirred at 70 C until the solid appeared. The productswere filtered, air-dried, and recrystallized from ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2698-41-1, its application will become more common.

Reference:
Article; Ramesh, Rathinam; Lalitha, Appaswami; Research on Chemical Intermediates; vol. 41; 10; (2015); p. 8009 – 8017;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2698-41-1, Safety of 2-(2-Chlorobenzylidene)malononitrile

General procedure: A mixture of 1,3-indandione (0.153 g, 1.05 mmol), 2 (1 mmol), iodine (0.304 g, 1.2 mmol) and DMAP (0.366 g, 3 mmol) was stirred in CH3CN at 40 C. After stirring until conversion was completed, the reaction mixture was partioned between water and ethyl acetate. The aqueous layer was extracted three times with ethyl acetate (3 x 15 mL). The resulting organic layer was washed with 10% NaHSO3 (2 x 15 mL) and then dried over sodium sulfate. After concentration, the crude products 3a – 3n were purified by flash column chromatography

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Chlorobenzylidene)malononitrile, and friends who are interested can also refer to it.

Reference:
Article; Huang, Jiamin; Liu, Wenli; Wang, Changqing; Yang, Liu; Cao, Xiaohua; Tetrahedron Letters; vol. 61; 4; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 2698-41-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of hydrazine hydrate (1.5 mmol, 80%),ethyl acetoacetate (1 mmol), aromatic aldehydes (1mmol), malononitrile (1 mmol) and starch solution(4 mL), was stirred at desired temperature for 60-90 min. Progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to RT and diluted with water. The reaction mixture was filtered for the separation of product. The crude product was purified by recrystallization from ethanol to afford pure products in excellent yield.After removal of the extra added (for work-upprocess) water from the filtered solution, the starchsolution (4 mL) is recovered and reused for thesubsequent reaction.

The chemical industry reduces the impact on the environment during synthesis 2-(2-Chlorobenzylidene)malononitrile. I believe this compound will play a more active role in future production and life.

Related Products of 2698-41-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2-Arylidenemalononitriles 7 (1 mmol), indane-1,3-dione (2, 0.146 g,1 mmol), NaOAc (0.08 g, 1 mmol), TBBDA (0.14 g, 0.25 mmol) or PBBS(0.2 g) or TCBDA (0.1 g, 0.25 mmol) or PCBS (0.15 g), and EtOH (2 mL)were added to a test-tube. Then the mixture was magnetically stirredat r.t. for the duration as shown in Table 4 and reaction progress wasmonitored by TLC (n-hexane/acetone, 5:2). The mixture was filteredand rinsed with EtOH (2 ¡Á 1 mL). The pure product was isolated byfiltration through a Buechner funnel. Then, the filtrate was evaporated and washed with hot water, CH2Cl2 (3 mL) was added, and the precipitatedsulfonamide was removed by filtration. The sulfonamide wasrehalogenated and used several times. 3-(4-Chlorophenyl)-1?,3?-dioxo-1?,3?-dihydrospiro[cyclopropane-1,2?-indene]-2,2-dicarbonitrile (6a)White solid; yield: 315 mg (95%); mp 199-200 C.IR (KBr): 3075, 3017, 2250, 1746, 1711, 1590, 1499, 1356, 1222, 1093,753, 584 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 4.41 (s, 1 H, CH), 7.61 (d, J = 8.4 Hz,2 H, ArH), 7.66 (d, J = 8.4 Hz, 2 H, ArH), 8.17 (m, 3 H, ArH), 8.26 (d, J =6.4 Hz, 1 H, ArH).13C NMR (100 MHz, DMSO-d6): delta = 20.4, 40.8, 43.8, 110.3, 111.9,123.0, 123.2, 127.3, 128.2, 132.0, 133.4, 136.0, 136.1, 141.5, 142.4,188.9, 190.0.MS: m/z (%) = 332 (M+, 53), 297 (100), 269 (21), 241 (36), 214 (40),187 (14), 165 (37), 138 (19), 104 (100), 76 (97).

The chemical industry reduces the impact on the environment during synthesis 2-(2-Chlorobenzylidene)malononitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ghorbani-Vaghei, Ramin; Maghbooli, Yaser; Synthesis; vol. 48; 21; (2016); p. 3803 – 3811;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2698-41-1

General procedure: Catalyst 1 (5 mol%) was added to a mixture of ,-unsaturatedmalonate (5 mmol) and diethyl phosphite (10 mmol). The mixturewas stirred at 70 C for the appropriate time (Table 2). The catalystwas separated by a magnetic bar from the cooled mixture,washed with EtOH, dried 30 min at 110 C and reused for a consecutiverun under the same reaction conditions. Evaporation of thesolvent of the remaining solution under reduced pressure gave thecrude products. The pure products (2-18, Table 2) were isolated bychromatography on silica gel eluted with n-hexane:EtOAc (1:2).

According to the analysis of related databases, 2698-41-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sobhani, Sara; Bazrafshan, Mahboobeh; Delluei, Amin Arabshahi; Parizi, Zahra Pakdin; Applied Catalysis A: General; vol. 454; (2013); p. 145 – 151;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts