Application of 26830-95-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methyl-2-nitrobenzonitrile, and friends who are interested can also refer to it.

Related Products of 26830-95-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-95-5 name is 4-Methyl-2-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-methyl-2-nitrobenzonitrile (0 ¡¤ 2mmol, 32 ¡¤ 4mg) ,tetrahydroxydiboron (0.6mmol, 53.8 mg), glacial acetic acid (0.24mmol, 14.5mg), cuprous chloride (0.04mmol, 4.0mg), Benzaldehyde (0¡¤24mmol, 25¡¤4mg), methanol (1ml), water (1ml) were added to the test tube, reacted at 60 C for 3h, after the completion of reaction, the reaction solution was extracted with ethyl acetate three times, the combined organic phases are concentrated to dryness, separated through column chromatography (petroleum ether: ethyl acetate =4:1), Yield:(34.8mg,73%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methyl-2-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; China Three Gorges University; Zhou Haifeng; Sui Yuebo; Jiang Xiaolan; Yang Bing; Yu Tao; (16 pag.)CN108558778; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

New downstream synthetic route of 26830-95-5

According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.

Application of 26830-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26830-95-5 as follows.

a 2-Amino-4-methylbenzonitrile A mixture of 4-methyl-2-nitrobenzonitrile (4.9 g, 30 mmol) and 10% palladium on carbon (500 mg) in 1,4-dioxane (60 mL) was stirred under hydrogen (balloon) overnight. The catalyst was removed by filtration through the Celite, and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography (dichloromethane) to give the title compound as a pale yellow solid (3.3 g, 83%). 1 H-NMR (300 MHz, CDCl3) delta 7.26 (d, J=8.3 Hz, 1H), 6.56 (s, 1H), 6.55 (s, 1H), 4.32 (br s, 2H), 2.29 (s, 3H).

According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3-Dimensional Pharmaceuticals, Inc.; US5891909; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Research on new synthetic routes about 26830-95-5

The synthetic route of 26830-95-5 has been constantly updated, and we look forward to future research findings.

26830-95-5, name is 4-Methyl-2-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Methyl-2-nitrobenzonitrile

Example 17: Alternative preparation of 4-cyano-3-nitro-benzoic acid; Under an inert atmosphere, periodic acid (492 g, 2.17 mol) was dissolved in acetonitrile (7.7 1) with vigorous stirring, and then, after 15 minutes chromium(VI) oxide (25 g, 0.25 mol) and 4-methyl-2-nitro-benzonitrile (100 g, 0.62 mol) were added successively. The reaction mixture was stirred at ambient temperature for 16 hours. The reaction mixture was decanted and the supernatant filtered. The filtrate was concentrated and the residue partitioned between aqueous sodium carbonate (IM) and dichloromethane. The precipitate was isolated by filtration to give 4-cyano-3-nitro-benzoic acid (150 g). The filtrate was extracted twice with dichloromethane and was then acidified by addition of aqueous hydrochloric acid (4N) to pH 1. The acidified filtrate was then extracted three times with dichloromethane. The combined organic extracts were dried over sodium sulfate and concentrated. This residue was partitioned between aqueous sodium carbonate (IM) and dichloromethane. The precipitate was isolated by filtration to give 4-cyano-3-nitro-benzoic acid (26.67 g). Total yield: 150 g + 26.67 g = 176.67 g; 74.5 % yield.

The synthetic route of 26830-95-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008/74427; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Share a compound : 26830-95-5

According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.

Related Products of 26830-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26830-95-5 as follows.

Step 1. Preparation of 2-amino-4-methyl-benzonitrile (B10-1): A solution of 4-methyl-2-nitrobenzonitrile (10 g, 61.72 mmol) in ethanol (200 mL) was charged to a Parr reactor and treated with 10% Pd/C (1 g). The contents of the reactor were then hydrogenated at 50 Psi hydrogen pressure 25 C. for 90 minutes. The reaction mixture was filtered through a Celite bed and washed with ethanol. The combined filtrates were the concentrated to provide B10-1. Yield: 8.5 g. 1H NMR (CDCl3): delta 7.28 (s, 1H), 6.5-6.62 (m, 2H), 4.2-4.42 (broad, 2H) and 2.3 (s, 3H). Mass: (M-1) 132 calculated for C8H8N2. The product was used without further purification to prepare B10-2 in the step described below.

According to the analysis of related databases, 26830-95-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US2009/54395; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts