Related Products of 26830-95-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-95-5 name is 4-Methyl-2-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-methyl-2-nitrobenzonitrile (0 ¡¤ 2mmol, 32 ¡¤ 4mg) ,tetrahydroxydiboron (0.6mmol, 53.8 mg), glacial acetic acid (0.24mmol, 14.5mg), cuprous chloride (0.04mmol, 4.0mg), Benzaldehyde (0¡¤24mmol, 25¡¤4mg), methanol (1ml), water (1ml) were added to the test tube, reacted at 60 C for 3h, after the completion of reaction, the reaction solution was extracted with ethyl acetate three times, the combined organic phases are concentrated to dryness, separated through column chromatography (petroleum ether: ethyl acetate =4:1), Yield:(34.8mg,73%)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methyl-2-nitrobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; China Three Gorges University; Zhou Haifeng; Sui Yuebo; Jiang Xiaolan; Yang Bing; Yu Tao; (16 pag.)CN108558778; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts