Category: 263389-54-4

Zhang, Xiao-Meng published the artcile4-(3-Fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazole, Application of a-Tosyl-(4-methoxybenzyl) isocyanide, the main research area is crystal structure fluoromethoxyphenylmethoxyphenyltrimethoxyphenylimidazole; mol structure fluoromethoxyphenylmethoxyphenyltrimethoxyphenylimidazole; imidazole fluoromethoxyphenylmethoxyphenyltrimethoxyphenyl crystal mol structure.

In 4-(3-fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazole, C26H25FN2O5, the fluoromethoxy-, methoxy- and trimethoxy-substituted benzene rings form dihedral angles of 12.65(2), 84.15(2) and 55.67(2)°, resp., with the imidazole ring. The crystal structure is stabilized weak intermol. C-H···F and C-H···O H bonds. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application of a-Tosyl-(4-methoxybenzyl) isocyanide.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lu, Kui published the artcileSynthesis of Substituted Pyrroles via Copper-Catalyzed Cyclization of Ethyl Allenoates with Activated Isocyanides, Product Details of C16H15NO3S, the main research area is pyrrole preparation; ethyl allenoate isocyanide cyclization copper catalyst; allenoates; copper; cyclization; isocyanides; pyrrole synthesis.

A new method for the synthesis of di- and trisubstituted pyrroles I (R1 = H, CH3, t-Bu, Bn, Ph, etc.; R2 = H, CH3, C2H5, Bn, 4-CH3OC6H4, 4-FC6H4; R3 = Ts, 4-ClC6H4SO2, 4-FC6H4SO2, 4-CH3OC6H4SO2, C6H5SO2) via copper-catalyzed cyclization of Et allenoates with activated isocyanides has been developed. In contrast to related annulation reactions previously reported, this new process features a skeletal rearrangement in which the aryl sulfonyl moiety, which functions as the electron-withdrawing group in the α-carbon of the isocyanide, was found to migrate to the γ-carbon of the starting allenoate in the final product for the first time.

Chemistry – An Asian Journal published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Product Details of C16H15NO3S.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sisko, Joseph published the artcileAn investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents, SDS of cas: 263389-54-4, the main research area is imidazole phenyl preparation; oxazole aryl preparation; tosylmethyl isonitrile cyclocondensation imine; amine aldehyde tosylmethyl isonitrile cyclocondensation; amino acid aldehyde tosylmethylisonitrile cyclocondensation; aldehyde ammonium hydroxide cyclization tosylmethyl isonitrile.

Efficient and mild protocols are described for preparing polysubstituted imidazoles in a single pot from aryl-substituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in situ. Traditional imine-forming reactions employing virtually any aldehyde and an amine followed by addition of the TosMIC reagent gave 1,4,5-tri-substituted imidazoles with predictable regiochem. Thus, condensation of pyruvaldehyde with (MeO)2CHCH2NH2 in THF at ambient temperature for 15 min and subsequent reaction with 4-FC6H4CH(Tos)N+C- [Tos = 4-MeC6H4SO2] in the presence of piperazine for 18 h gave 71% [(fluorophenyl)imidazolyl]ethanone I. Employing chiral amines and aldehydes, particularly those derived from α-amino acids, gave imidazoles, e.g. II, with asym. centers appended to N-1 or C-5 with excellent retention of chiral purity. 1,4-Disubstituted imidazoles were also readily prepared by a simple variant of the above procedure. Selection of glyoxylic acid as the aldehyde component of the procedure lead to intermediates such as III which readily underwent decarboxylation and elimination of the tosyl moiety to give 1,4-disubstituted imidazoles in high yields. Alternatively, using NH4OH as the amine component in conjunction with a variety of aldehydes gave 4,5-disubstituted imidazoles in moderate to good yields in a single pot while avoiding the need for protecting groups. Finally, the facile preparation of mono- and disubstituted oxazoles, e.g. IV, from these TosMIC reagents and aldehydes was described.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, SDS of cas: 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Plante, Jeffrey P. published the artcileShape-selective fluorescent sensing ensemble using a tweezer-type metalloreceptor, Application In Synthesis of 263389-54-4, the main research area is heteroaromatic shape selective fluorescent sensing bisimidazole pyridine derived metalloreceptor; tweezer type copper bisimidazole pyridine derived metalloreceptor fluorescent sensor.

A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble was prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine bind strongly in the cavity. The fluorescent response is provided by a dye which is coordinated to the receptor and quenched by the metal ion. The dye is released upon guest binding providing up to 25-fold fluorescence increases.

Organic Letters published new progress about Fluorescence. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application In Synthesis of 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Geigle, Stefanie N. published the artcileDevelopment of DNA-Compatible Van Leusen Three-Component Imidazole Synthesis, Application In Synthesis of 263389-54-4, the main research area is DNA compatible three component imidazole synthesis.

DNA-encoded libraries (DELs) have generated recent interest due to their ability to provide new small mol. ligands for pharmaceutically important proteins. The chem. diversity of DELs determines their ability to provide potent, novel, and drug-like chem. matter, and DEL chem. diversity is limited by the scope of DNA-compatible chem. reactions. Herein, the one-pot three-component Van Leusen chem. is applied to DEL synthesis, providing the first reported DNA-compatible method to generate novel highly functionalized imidazoles.

Organic Letters published new progress about van Leusen three-component reaction. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application In Synthesis of 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Satyam, Killari published the artcileThe base-free Van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives, Category: nitriles-buliding-blocks, the main research area is dihydro imidazopyridoindole preparation green chem; dihydrocarboline tosylmethyl isocyanide Van Leusen reaction.

Construction of substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I (R = H, Et, Ph, etc.; R1 = H, 8-Br; R2 = H, 6-Ph, 5-Me, etc.) has been demonstrated on water under base-free conditions. The reaction of p-toluenesulfonylmethyl isocyanides 4-CH3C6H4SO2CH(R)NC and dihydro β-carboline imines II (R3 = H, 6-Br; R4 = H, 4-Ph, 3-Me, etc.) furnished the corresponding substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.

Organic & Biomolecular Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts