Category: 263159-64-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 263159-64-4, name is 2-Bromo-3-methylbenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 263159-64-4

Step 3: A mixture of compound 249 (1 1 g, 56.1 mmol), NBS (10 g, 56.1 mmol) and BPO (81 mg, 0.34 mmol) in CCI4 (150 mL) was heated at reflux overnight. TLC (petroleum ether / EtOAc = 5:1 ) showed the reaction was completed. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography over silica gel (petroleum ether / EtOAc = 20:1 ) to yield compound 250 (9.6 g, 62%) as a white solid. 1H NMR (400 MHz, CDCI3) delta 7.69- 7.67 (d, 1 H), 7.63-7.61 (d, 1 H), 7.45-7.41 (t, 1 H), 4.61 (s, 2H)

The synthetic route of 263159-64-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 263159-64-4, name is 2-Bromo-3-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrN

To a solution of 2-bromo-3-methylbenzonitrile (12 g, 51 mmol, 1.0 eq) in tetrachloromethane (127.5mL) was added N-bromosuccinimide (10 g, 56.1 mmol, 1.1 eq) and Bz2O2 (0.075 g, 0.31 mmol, 0.006 eq) at r.t. The reaction flask was vacuumed and backfilled by nitrogen. The reaction was stirred at reflux overnight. The reaction was cooled and stirred at r.t. Insoluble matter was removed by filtration. The filtrate was cooled with ice-water, and then filtered to give 2-bromo-3- (bromomethyl)benzonitrile (7.6 g, yield 54%): Purity by IH-NMR: 90%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 263159-64-4.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; ZHOU, Huchen; DING, Dazhong; ZHOU, Yasheen; ZHANG, Yong-Kang; PLATTNER, Jacob J.; WO2011/22337; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts