Category: 25309-65-3

Reference of 25309-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25309-65-3 name is 4-Ethylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-ethylbenzonitrile (1.31 g, 10 mmol) was added to 6 mL of 9N H2SO4 at 0 C. NBS (10 mmol) was added, followed by 6 mL of CH3CN. The flask was wrapped with aluminum foil, and the mixture was stirred vigorously at room temperature for 2 days. Ether/aqueous extraction followed by column separation gave 3-bromo-4-ethylbenzonitrile as colorless oil (1.30 g, 61.6%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Ethylbenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Synta Pharmaceuticals Corp.; Chen, Shoujun; Bohnert, Gary; Jiang, Jun; Xia, Zhiqiang; (151 pag.)US9604978; (2017); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 25309-65-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25309-65-3, name is 4-Ethylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 27 Preparation of 2-(p-ethylphenyl)-5(6)-methoxybenzimidazole 5.0 g. of p-ethylbenzonitrile in 40 ml. of methanolic hydrochloric acid was stirred at room temperature overnight. The reaction mixture was diluted with water, neutralized with sodium carbonate and extracted with n-hexane. The extract was evaporated in vacuo to remove n-hexane. The remaining alkoxyimine compound was dissolved in methanol and 4.7 g. of p-anisidine was added thereto. The mixture was warmed for 30 minutes and evaporated in vacuo to remove methanol, whereby N-(p-methoxyphenyl)-4-ethylbenzamidine was recovered. This product was dissolved in water and then acidified with hydrochloric acid.

The synthetic route of 4-Ethylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kanebo, Ltd.; US4188486; (1980); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 25309-65-3,Some common heterocyclic compound, 25309-65-3, name is 4-Ethylbenzonitrile, molecular formula is C9H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A. Methyl 4-ethylbenzenecarboximidoate Hydrodrochloride Hydrogen chloride gas was bubbled through a methanol solution of 4-ethylbenzonitrile (5.0 g, 38.11 mmol) at 0 C. for 30 minutes. The reaction was sealed and stood at ambient temperature overnight. The solvent was removed in vacuo and the oily residue triturated with diethyl ether. The resulting solid was removed to yield the title compound which was stored in a dry atmosphere.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Ethylbenzonitrile, its application will become more common.

Reference:
Patent; American Home Products Corporation; US2002/22638; (2002); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts