Category: 2510-01-2

On April 29, 2005, Xue, Dong; Chen, Ying-Chun; Cui, Xin; Wang, Qi-Wei; Zhu, Jin; Deng, Jin-Gen published an article.Electric Literature of 2510-01-2 The title of the article was Transfer Hydrogenation of Activated C:C Bonds Catalyzed by Ruthenium Amido Complexes: Reaction Scope, Limitation, and Enantioselectivity. And the article contained the following:

It was found that the chemoselectivity could be completely switched from C:O to C:C bonds in the transfer hydrogenation of activated α,β-unsaturated ketones R1CH:CR2COR3 (R1 = Ph, 4-MeOC6H4, 4-O2NC6H4; R2 = H, Me, MeCO, EtO2C; R3 = Me, Ph) catalyzed by diamine-ruthenium complex. Moreover, this addition via metal hydride had been applied to the reduction of various activated olefins R4R5C:CR6R7 (R4 = H, Me; R5 = H, n-C5H11, Ph, 4-MeOC6H4, 4-O2NC6H4; R6 = CN, EtO2C, Ph, O2N, etc.; R7 = H, CN, O2N, HO2C, etc.). The electron-withdrawing ability of functional groups substituted on C:C bonds at the α- or β-position had strong influence on the reactivity. In addition, a wide variety of chiral diamine-Ru(II)(arene) systems was investigated to explore the asym. transfer hydrogenation of prochiral α,α-dicyanoolefins. Two parameters had been systematically studied: (i) the structure of the N-sulfonylated chiral diamine ligands and (ii) the structure of the metal precursors. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to ketone unsaturated stereoselective chemoselective transfer hydrogenation ruthenium amido complex, dinitrile enantioselective transfer hydrogenation ruthenium amido complex, alkene activated transfer hydrogenation ruthenium amido complex, sulfonamide amino preparation chiral ligand asym transfer hydrogenation and other aspects.Electric Literature of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 25, 2022, Zhu, Lixiang; Peng, Heling; Guo, Yan; Che, Jixing; Wu, Jia-Hong; Su, Zhishan; Wang, Tianli published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral-Phosphonium-Salt-Enabled Cascade Arene Formation. And the article contained the following:

Axially chiral biaryl monophosphorus mols., exemplified by atropisomeric 1,1′-biaryl aminophosphines, are significant motifs in numerous chiral ligands/catalysts. Developing efficient methods for preparing P compounds with these privileged motifs is an important endeavor in synthetic chem. Herein, the authors develop an effective, modular method by a chiral-phosphonium-salt-catalyzed novel cascade between P-containing nitroolefins and α,α-dicyanoolefins, leading to a great diversity of atropisomeric biaryls bearing P groups in high yields with excellent stereoselectivities. The reaction features include a Thorpe-type cycloaddition/oxidative hydroxylation/aromatization cascade pathway with a central-to-axial chirality transfer process. Insight gained from the authors’ studies is expected to advance general efforts towards the catalytic synthesis of atropisomeric biaryl P compounds, offering a platform for developing new efficient chiral ligands and catalysts. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to naphthyl nitroolefin cycloaddition cyanoolefin chiral phosphonium salt catalyst, aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative preparation crystal structure, mol structure aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative, atropisomerism, biaryl phosphines and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On November 26, 1986, Koeckritz, Peter; Liebscher, Juergen; Schmidt, Ludmilla published a patent.Computed Properties of 2510-01-2 The title of the patent was Preparation of 2,3,N,N-tetrasubstituted-1,1-dicyano-4-amino-1,3-butadienes useful as intermediates for analgesics, etc.. And the patent contained the following:

The title compounds (R2)2NCH:CR1CR:C(CN)2 [I; R, R1 = H, (un)substituted alkyl or alkenyl, aryl, heteroaryl; RR1 = (CH2)3-5, CH2NH(CH2)2, benzo-condensed alkenylene, e.g., o-C6H4CH2CH2; R2 = alkyl; R2R2 = (CH2)4-5, (CH2)2O(CH2)2, (CH2)2NH(CH2)2], useful as intermediates for heterocyclic compounds with antiphlogistic, analgesic, or antirheumatic activity, are prepared by reacting R1CH2CR:C(CN)2 with (R2)2NCH(OR3)2 (R3 = alkyl) in the presence of a protonic acid. A solution of Me2C:C(CN)2 in AcOH was treated with (R2)2NCH(OMe)2 [R2R2 = (CH2)2O(CH2)2] and the mixture was warmed to boiling to give 81% I [R = Me, R1 = H, R2R2 = (CH2)2O(CH2)2]. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to analgesic intermediate aminocyanobutadiene preparation, antiphlogistic intermediate aminocyanobutadiene preparation, antirheumatic intermediate aminocyanobutadiene preparation, heterocycle intermediate aminocyanobutadiene preparation, aminocyanobutadiene preparation heterocycle intermediate, cyanobutadiene amino preparation heterocycle intermediate and other aspects.Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts