Category: 2510-01-2

On May 31, 1987, Bogdanowicz-Szwed, Krystyna; Feret, Hanna; Lipowska, Malgorzata published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was The reaction of malononitrile with some enamines of 1-indanone. Synthesis of o-aminonitriles of indenopyridine and indenothiopyran. And the article contained the following:

Condensation of indanone enamines I (X = O, R = Ph, C6H4Cl-4) with H2C(CN)2 (II) give indenylidenemalononitriles III in 75 and 80% yields, resp. Cyclization of III with NaOH gave indenopyridones IV (X = O, X1 = NR) in 54 and 80% yields, resp. Condensation of thioamide I (X = S, R= C6H4R1-4, R1 = H, Cl, Br, Me) with II gave indenothiopyrano IV (X = NR, X1 = S) in 64-88% yields. Rearrangement of the thiopyrano gave indenothiopyridones IV (X = S, X1 = NR) in 67-85% yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to indanone enamine condensation malononitrile, indenylidenemalononitrile cyclization hydroxide, indenopyridone aminocyano, indenothiopyran aminocyano rearrangement hydroxide, rearrangement aminocyanoindenothiopyran hydroxide, indenothiopyridone aminocyano and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 11, 2007, Wang, Xiang-Shan; Zhang, Mei-Mei; Li, Qing; Yao, Chang-Sheng; Tu, Shu-Jiang published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was An improved and clean procedure for the synthesis of one-donor poly-acceptors systems containing 2,6-dicyanoamine moiety in aqueous media catalyzed by TEBAC in the presence and absence of K2CO3. And the article contained the following:

A clean and simple synthesis of one-donor poly-acceptors systems containing 2,6-dicyanoamine moiety was accomplished via the reaction of 1-arylethylidenemalonodinitriles with arylidenemalonodinitriles in aqueous media catalyzed by TEBAC in the presence of K2CO3. The important intermediates were obtained successfully to confirm the mechanism in the absence of base under the same reaction conditions. The structures of I and II were confirmed by x-ray diffraction studies. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to aminodicyanodihydrophenanthrene preparation, aminoaryltricyanotetrahydrophenanthrene preparation, aminodiarylcyclohexadienetricarbonitrile preparation, arylidenemalonodinitrile dihydronaphthalenylidene malononitrile cycloaddition tebac, tebac cycloaddition catalyst and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cui, Hai-Lei; Peng, Jing; Feng, Xin; Du, Wei; Jiang, Kun; Chen, Ying-Chun published an article in 2009, the title of the article was Dual organocatalysis: asymmetric allylic-allylic alkylation of α,α-dicyanoalkenes and Morita-Baylis-Hillman carbonates.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

The first highly enantioselective allylic-allylic alkylation of α,α-dicyanoalkenes I (RR1 = 2-C6H4SCH2, 2-C6H4OCH2; R = 2-thienyl, R1 = H; etc) and Morita-Baylis-Hillman carbonates II (R2 = 4-ClC6H4, E = CO2Me; R2 = Ph, E = CN; etc.) by dual catalysis of (DHQD)2AQN and (S)-BINOL was investigated. Excellent stereoselectivities were achieved for a broad spectrum of substrates (d.r. > 99:1, up to 99% ee). The multifunctional allylic products, e.g., III (RR1 = 2-C6H4SCH2, R2 = 4-ClC6H4, E = CO2Me) could be efficiently converted to a range of complex chiral cyclic frameworks. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to cyano alkene asym allylic alkylation carbonate cinchona alkaloid catalyst, diene dinitrile stereoselective preparation intramol michael, asym cyano cyclohexene preparation, cinchona alkaloid binol preparation asym allylic alkylation dual catalysis and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 7, 2009, Xiong, Xiao-Feng; Jia, Zhi-Jun; Du, Wei; Jiang, Kun; Liu, Tian-Yu; Chen, Ying-Chun published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines. And the article contained the following:

An enantio- and diastereoselective direct vinylogous Mannich reaction of α,α-dicyanoolefins and N-sulfonyl alkylimines has been developed. Using the catalysis of a new family of bifunctional organocatalysts merging chiral BINOL and 9-amino-9-deoxyepi-cinchona alkaloid skeletons, chiral β-, δ- or γ-amino compounds could be efficiently derived. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to cinchona alkaloid binol derived chiral bifunctional organocatalyst preparation, dicyanoolefin sulfonyl alkylimine chiral bifunctional organocatalyst vinylogous mannich addition, amino dicyanoolefin derivative stereoselective preparation and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Xing-Li; He, Wu-Jun; Yu, Liang-Liang; Cai, Chang-Wu; Zuo, Zong-Le; Qin, Da-Bin; Liu, Quan-Zhong; Jing, Lin-Hai published an article in 2012, the title of the article was Organocatalytic asymmetric vinylogous Michael addition of dicyanoolefins to imine intermediates generated in situ from arenesulfonylalkylindoles.Synthetic Route of 2510-01-2 And the article contains the following content:

An organocatalytic asym. vinylogous Michael addition of dicyanoolefins to vinylogous imine intermediates generated in situ from arenesulfonylalkylindoles has been developed. This protocol provides an easy and convenient approach to C-3 alkyl-substituted indole derivatives with high yields (up to 93%), diastereomeric ratios (up to 99:1 dr) and enantioselectivities (up to 99% ee). The resulting adducts can be also readily converted to pyrazolo derivatives or α-alkylation products of ketones without any decrease of the diastereoselectivities and enantioselectivities. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

The Article related to arenesulfonylalkylindole imine organocatalytic asym vinylogous michael addition dicyanoolefin, alkyl indole derivative enantioselective diastereoselective synthesis alkylation ketone pyrazole, michael adduct crystal structure and other aspects.Synthetic Route of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 1, 2010, Peng, Jing; Huang, Xin; Cui, Hai-Lei; Chen, Ying-Chun published an article.SDS of cas: 2510-01-2 The title of the article was Organocatalytic and Electrophilic Approach to Oxindoles with C3-Quaternary Stereocenters. And the article contained the following:

A Lewis base-catalyzed asym. allylic alkylation of Morita-Baylis-Hillman carbonates derived from isatins has been investigated, which provides an electrophilic pathway to access oxindoles, e.g. I, bearing C3-quaternary stereocenters. Excellent diastereoselectivity and high enantioselectivity have been obtained in the vinylogous functionalization of α,α-dicyanoolefin nucleophiles, giving multifunctional products with vicinal quaternary and tertiary chiral carbon centers. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to organocatalytic electrophilic oxindole preparation enantioselective diastereoselective allylic alkylation, spirocyclic oxindole preparation diastereoselective enantioselective intramol michael addition cyclization, lewis base catalyst allylic alkylation dicyanoolefin oxindole carbonate reactant, quaternary oxindole preparation stereoselective allylic alkylation and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matsnev, Andrej; Noritake, Shun; Nomura, Yoshinori; Tokunaga, Etsuko; Nakamura, Shuichi; Shibata, Norio published an article in 2010, the title of the article was Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes.Computed Properties of 2510-01-2 And the article contains the following content:

S-(trifluoromethyl)benzo[b]thiophenium salts, as analogs of Yagupolskii-Umemoto type reagents, were synthesized by novel triflic acid mediated intramol. cyclization of ortho-ethynylaryltrifluoromethylsulfanes. Cyclopropyl analog I is especially useful for the electrophilic trifluoromethylation of β-ketoesters and dicyanoalkylidenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to ortho ethynylaryltrifluoromethylsulfane preparation triflic acid intramol cyclization, benzothiophenium salt trifluoromethyl derivative preparation yagupolskii umemoto reagent analog, beta keto ester sulfur trifluoromethyl benzothiophenium salt electrophilic trifluoromethylation and other aspects.Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 15, 2005, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Sensing of Antipyretic Carboxylates by Simple Chromogenic Calix[4]pyrroles. And the article contained the following:

A simple, two- or three-step method for the synthesis of chromogenic octamethyl calix[4]pyrrole-based (OMCP) sensors for anions was presented. Electrophilic aromatic substitution allows for converting the pyrrole moieties of OMCP into a dye. The formation of a sensor-anion complex results in partial charge transfer and a dramatic change in color. The absorption (UV-vis) and NMR titration experiments show that the chromogenic OMCPs sense anions administered as aqueous solutions, even at high ionic strength (∼0.1 M NaCl), while displaying selectivity for pyrophosphate and carboxylate anions. The experiments with polyurethane sensor films show a strong response for aqueous carboxylates, such as antipyretics naproxen ≈ ibuprofen > salicylate, without being biased by bicarbonate or carboxy termini of blood plasma proteins. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to antipyretic ibuprofen salicylate naproxen carboxylate chromogenic calixpyrrole preparation, chromogenic calix pyrrole sensor anion preparation, sensor anion complex chromogenic calixpyrrole preparation color change, polyurethane sensor film anion complex chromogenic calixpyrrole color change and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 21, 2007, Liu, Tian-Yu; Cui, Hai-Lei; Long, Jun; Li, Bang-Jing; Wu, Yong; Ding, Li-Sheng; Chen, Ying-Chun published an article.Application of 2510-01-2 The title of the article was Organocatalytic and Highly Stereoselective Direct Vinylogous Mannich Reaction. And the article contained the following:

The first direct asym. vinylogous Mannich (AVM) reaction of α,α-dicyanoolefins and N-Boc aldimines was described promoted by a simple chiral bifunctional thiourea-tertiary amine organocatalyst. The reaction was highly efficient (S/C up to 1000) and regio-, stereoselective (generally >99% de, >96% ee) at room temperature for a broad array of substrates. Enantiomerically pure δ-amino acid and subsequential δ-lactam could be smoothly prepared from the adduct. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to dicyanoolefin aldimine chiral thiourea tertiary amine asym vinylogous mannich, dicyanovinyl amine stereoselective preparation reduction hydrolysis, amino acid stereoselective preparation amidation, lactam stereoselective preparation, asym vinylogous mannich catalyst chiral thiourea tertiary amine and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 24, 2020, Zhuo, Jun-Rui; Quan, Bao-Xue; Zhao, Jian-Qiang; Zhang, Ming-Liang; Chen, Yong-Zheng; Zhang, Xiao-Mei; Yuan, Wei-Cheng published an article.SDS of cas: 2510-01-2 The title of the article was Base-mediated [4+2] annulation of electron-deficient nitrobenzoheterocycles and α,α-dicyanoalkenes in water: Facile access to structurally diverse functionalized dibenzoheterocyclic compounds. And the article contained the following:

A base-mediated [4 + 2] annulation of electron-deficient nitrobenzoheterocycles with α,α-dicyanoalkenes for the synthesis of structurally diverse dibenzoheterocyclic compounds was reported. Reaction of 2-nitrobenzofurans/2-nitrobenzothiophenes with α,α-dicyanoalkenes afforded fused-benzofuran-carbonitrile derivatives and fused-benzothiophene-carbonitrile derivatives I [R1 = H, 10-Me, 10-Cl, etc.; R2 = H, 3-Me, 2-OMe, 4-Br, etc.; R3R4 = H, (CH2)2, OCH2, etc.; X = O, S]. Reaction between 3-nitrobenzothiophenes and α,α-dicyanoalkenes was developed to give fused-benzothiophene-carbonitrile derivatives II [R5 = H, 10-Me, 10-F, 10-Cl, 10-Ph; R6R7 = H, (CH2)2, OCH2, etc.]. Synthesis of fused-indole derivatives III [R8 = H, 10-F, 10-Cl, 11-Br; R9 = acetyl, tert-butyloxycarbonyl, tosyl; R10R11 = H, OCH2, (CH2)2, (CH2)3] by reaction of 3-nitroindoles and α,α-dicyanoalkenes was reported. Preparation of polycyclic heteroaromatic compounds IV [R12 = H, 10-OMe, 10-F, etc.] via oxidative dehydrogenation of some of the fused-benzofuran-carbonitrile derivatives I was reported. The reaction proceeded smoothly via a tandem vinylogous Michael addition/cyclization/tautomerization/elimination process in water with cesium carbonate as base, affording a wide range of dibenzofurans, dibenzothiophenes and carbazoles in good to high yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to dibenzoheterocyclic compound green preparation, nitrobenzoheterocycle dicyanoalkene tandem annulation base mediated, polycyclic heteroaromatic compound preparation, fused benzofuran carbonitrile derivative oxidative dehydrogenation, amino phenyl dihydrophenanthrobenzofuran carbonitrile preparation and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts