Category: 2510-01-2

On February 7, 2008, Aleman, Jose; Jacobsen, Christian Borch; Frisch, Kim; Overgaard, Jacob; Jorgensen, Karl Anker published an article.Application of 2510-01-2 The title of the article was Organocatalytic asymmetric vinylogous addition to quinones – formation of optically active α-aryl ketones. And the article contained the following:

The organocatalytic addition of dicyanoalkylidenes to quinones catalyzed by cinchona alkaloids to give 1,4-diketones with high diastereomeric ratios (up to >98:<2 dr) and enantioselectivities (up to 99% ee) has been developed; the optically active compounds obtained are useful for a number of transformations, e.g. the synthesis of optically active α-aryl ketones. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to quinone stereoselective addition alkylidenemalononitrile cinchona alkaloid catalyst, ketone aromatic asym synthesis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Naphthalenes and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 31, 2008, Noritake, Shun; Shibata, Norio; Nakamura, Shuichi; Toru, Takeshi; Shiro, Motoo published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Fluorinated Johnson reagent for transfer-trifluoromethylation to carbon nucleophiles. And the article contained the following:

A novel reagent, [(oxido)phenyl(trifluoromethyl)-λ4-sulfanylidene]dimethylammonium tetrafluoroborate has been developed for the electrophilic trifluoromethylation of carbon nucleophiles. The reagent was designed as a trifluorinated version of a Johnson-type methyl-transfer reagent. The first example of vinylogous trifluoromethylation of dicyanoalkylidenes is also demonstrated. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to fluorinated johnson reagent transfer trifluoromethylation carbon nucleophile, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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Elslager, Edward F.; Jacob, Patricia; Werbel, Leslie M. published an article in 1972, the title of the article was Antimalarial drugs. 28. Folate antagonists. 6. Synthesis and antimalarial effects of fused 2,4-diaminothieno [2,3-d] pyrimidines.Category: nitriles-buliding-blocks And the article contains the following content:

2,4-Diamino-5,7 – dihydro – 6H – thiopyrano[4 ,3 :4,5]thieno[2,3-d]pyrimidine, 2,4-diamino-9H-indeno[1 ,2 :4,5]thieno[2,3-d]-pyrimidine, 2,4-diamino – 5H – indeno[2 ,1 :4,5]thieno[2,3 – d]-pyrimidine, 9,11-diamino-5,6-dihydronaphtho[1 ,2 :4,5]thieno-[2,3-d]pyrimidine, 7,9-diamino-5,6-dihydronaphtho[2 ,1 :4,5]-thieno[2,3-d]pyrimidine, 2,4-diamino – 7 – benzyl – 5,6,7,8 – tetrahydropyrido[4 ,3 :4,5]thieno[2,3-d]pyrimidine, and various 2,4-diamino – 5,6,7,8 – tetrahydro – [1]benzothieno[2,3 – d]pyrimidines were prepared by cyclization of the requisite fused 2-aminothiophene-3-carbonitriles with ClC(:NH)Nh2.HCl. Several compounds exhibited strong inhibitory effects against Streptococcus faecalis (MGH-2), Staphylococcus aureus (UC-76), Streptococcus faecalis (ATCC 8043), Lactobacillus casei (ATCC 7469), and Pediococcus cerevisiae (ATCC 8081) in vitro, and three compounds displayed slight antimalarial activity against Plasmodium berghei in mice and Plasmodium falciparum (Uganda I) in vitro. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to thienopyrimidine diamino fused, antimalarial fused diaminothienopyrimidine, antibacterial fused diaminothienopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
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Chen, Hui; Zhao, Sihan; Cheng, Shaobing; Dai, Xingjie; Xu, Xiaoying; Yuan, Weicheng; Zhang, Xiaomei published an article in 2019, the title of the article was Synthesis of Novel Pterocarpen Analogues via [3 + 2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines.Related Products of 2510-01-2 And the article contains the following content:

By employing triethylamine as a catalyst, [3+2]-coupling-elimination cascade of α,α-dicyano-olefins, e.g., I, with quinone monoimines, e.g., II, was realized. The reactions afforded various novel pterocarpen analogs, e.g., III, with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to pterocarpen analog preparation coupling elimination cascade triethylamine catalyst, Biomolecules and Their Synthetic Analogs: Flavonoids and Natural and Fused Coumarins and other aspects.Related Products of 2510-01-2

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Nitrile – Wikipedia,
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Liu, Yingtian; Dang, Xinxin; He, Yu; Bai, Hudong; Chen, Xuehong; Li, Jun-Long; Fan, Junting; Jiang, Hezhong; Li, Jiahong published an article in 2019, the title of the article was Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

A straightforward and efficient method was developed for the synthesis of 2-cyanoacrylamides R1R2C:C(CN)CONH2 [R1 = n-Pr, Ph, 4-MeOC6H4, PhCH:CH, 2-furyl, etc., R2 = H; R1 = Ph, R2 = Me, Ph; R1R2 = (CH2)5, o-C6H4CH2CH2, etc.] from 2-methylenemalononitriles R1R2C:C(CN)2 in good to excellent yields through monohydration under mild and simple reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to methylene malononitrile preparation diastereoselective monohydration palladium catalyst, cyano acrylamide preparation, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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On January 31, 2009, Liang, Jing; Zhang, Meimei; Wei, Xianyong; Zong, Zhimin; Wang, Xiangshan published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was One-step synthesis of fluorene or phenanthrene derivatives via the reaction of arylaldehyde and malononitrile with 2-(1,2-dihydroinden-3-ylidene)malononitrile or 2-(2,3-dihydronaphthalen-4(1H)-ylidene)-malononitrile catalyzed by KF/Al2O3 in ethyl alcohol. And the article contained the following:

A method for the synthesis of the title compounds [i.e., 3-amino-1-(phenyl)-9H-fluorene-2,4-dicarbonitrile derivatives and 3-amino-1-(phenyl)-9,10-dihydro-2,4-phenanthrenedicarbonitrile derivatives] is reported here. A series of fluorene or phenanthrene derivatives was synthesized from aryl aldehyde derivatives, malononitrile and 2-(1,2-dihydro-3-indenylidene)malononitrile or 2-(2,3-dihydro-4-naphthalenylidene)malononitrile catalyzed by KF/Al2O3 at 80° in ethanol. This method has the advantages, such as mild reaction conditions, high yields (72-88%) and easy operation. The structures of the products were characterized by IR, NMR, elemental anal. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to phenanthrene amino phenyl phenanthrenedicarbonitrile preparation, fluorene amino phenyl fluorenedicarbonitrile preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Anthracenes and Phenanthrenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 27, 2021, Fu, Jiya; Zhang, Chuanbao; Zhao, Lili; Li, Ran; Deng, Yihang; Yuan, Jinfang; Wang, Yanbo; Zhu, Junyan published a patent.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Preparation of spiro dihydrofluorene derivatives. And the patent contained the following:

The invention discloses a preparation of spiro dihydrofluorene derivative, which has the advantages of high efficiency, low cost and good application prospect. Spiro dihydrofluorene derivatives are shown in formula I, wherein R1 is selected from: CN or CO2 Me; R2 is selected from substituted Ph, substituted pyridyl, substituted furanyl, substituted thiophene or substituted naphthyl; R3 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, hydroxyl, alkoxy, nitro, ester, amino, acylamino, alkacyloxy, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy; R4 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, alkoxy, nitro, ester, amino, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy. Spiro dihydrofluorene derivatives were prepared via cyclization of 2-benzofuranone derivatives and 1-indene methylene malononitrile. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to spiro dihydrofluorene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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Qin, Wenbing; Lin, Weifeng; Li, Xin; Xiong, Wei; Liu, Guokai published an article in 2020, the title of the article was Difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt: efficient construction of difluoromethylated all-carbon-substituted centers.HPLC of Formula: 2510-01-2 And the article contains the following content:

An efficient approach for difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt under organic base was described. A wide range of structurally and functionally diverse dicyanoalkylidenes was readily transferred into corresponding desirable difluoromethylated compounds bearing difluoromethylated all-carbon-substituted centers in good to excellent yields under standard reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to difluoromethylation dicyanoalkylidene difluoromethyl sulfonium, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.HPLC of Formula: 2510-01-2

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Nitrile – Wikipedia,
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On August 7, 2015, Saidalimu, Ibrayim; Tokunaga, Etsuko; Shibata, Norio published an article.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Carbene-Induced Intra- vs Intermolecular Transfer-Fluoromethylation of Aryl Fluoromethylthio Compounds under Rhodium Catalysis. And the article contained the following:

The intra- vs intermol. transfer-fluoromethylation of aryl fluoromethylthio compounds is proposed. Finely designed ArSCF3 I [X = CF3] nicely releases its trifluoromethyl (CF3) group intermolecularly under rhodium catalysis, whereas a difluoromethylated analog, ArSCF2H I [X = CF2H] shows intramol. reaction. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to carbene induced transfer fluoromethylation aryl fluoromethylthio compound rhodium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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On July 31, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Kun, Jun; Son, Young-A. published an article.Electric Literature of 2510-01-2 The title of the article was Synthesis and Optical Properties of (A)n-π-(Ph)3N Type Dyes. And the article contained the following:

Two new (A)n-π-(Ph)3N type dyes were designed, synthesized and characterized. The optical properties and structures of them were studied, including UV-visible spectroscopy, photo-luminescence spectroscopy. The geometric structures of them were calculated theor. based on the DFT level using BLYP/GGA basis set, the HOMO/LOMO levels were also measured and calculated The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to dye synthesis optical property, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Optical Properties (Linear) and other aspects.Electric Literature of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts