Category: 2510-01-2

On April 26, 2001, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Aromatic aldehydes and ketones with imidazoles as coloring agents for keratin fibers. And the patent contained the following:

Oxidative hair dyes containing aromatic aldehydes and ketones combined with imidazoles and other heterocyclic compounds are disclosed. Aromatic components may include salicylaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, o-anisaldehyde, etc. Heterocyclic components may include 1,4-dimethylquinolinium salts, 1,2-dimethylquinolinium salts, 1,4-dimethylpyridinium salts, 3-ethyl-2-methylbenzothiazolium salts, etc. These may be combined with rhodanine, barbituric acid, thiobarbituric acid, oxindole, etc. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to oxidative hair dye aromatic ketone, Essential Oils and Cosmetics: Hair Preparations and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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Saidalimu, Ibrayim; Guo, Ming; Tokunaga, Etsuko; Shibata, Norio published an article in 2016, the title of the article was Direct Fluoro-aminosulfenylation of Active Methylenes by Dialkylaminosulfur Trifluorides under Catalyst-Free Conditions.SDS of cas: 2510-01-2 And the article contains the following content:

The direct fluoro-aminosulfenylation of active methylene compounds, e.g., 2-(2,3-dihydro-1H-inden-1-ylidene)malononitrile by diethylaminosulfur trifluoride and its derivatives F3SR (R = dimethylamino, diethylamino, bis(2-methoxyethyl)amino, morpholino) has been disclosed. A variety of α-fluorinated α-sulfenamides with a tetrasubstituted carbon center, e.g., I were synthesized from active methylene compounds under mild reaction conditions. This direct fluoro-aminosulfenylation reaction occurs very smoothly under metal-free and base-free conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to sulfenamide fluoro preparation, active methylene compound dialkylaminosulfur trifluoride fluoro aminosulfenylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 2510-01-2

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On June 30, 2001, Mishriky, N.; Girgis, A. S.; Asaad, F. M.; Ibrahim, Y. A.; Sobieh, U. I.; Fawzy, N. G. published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Simple synthesis of condensed pyran containing compounds and their antimicrobial properties. And the article contained the following:

Reaction of various fused pyran compounds with formic acid was studied. Thus, refluxing 6-aminopyrano[2,3-c]pyrazole-5-carbonitriles with formic acid afforded the corresponding 3-aryl-3-(5-hydroxy-3-methyl-1H-pyrazole-4-yl)propanoic acids. Reaction of formic acid with 2-amino-4H-1-benzopyran-3-carbonitriles gave quinoline-2,5(1H,6H)-diones. The study was also extended toward spiro compounds possessing pyran residue. The antimicrobial properties of the prepared compounds was screened. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to fused pyran preparation antimicrobial property, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On February 1, 2018, Yalcin, Ergin; Matkovic, Marija; Jukic, Marijana; Obrovac, Ljubica Glavas; Piantanida, Ivo; Seferoglu, Zeynel published an article.Application of 2510-01-2 The title of the article was Novel fluorene/fluorenone DNA and RNA binders as efficient non-toxic ds-RNA selective fluorescent probes. And the article contained the following:

A series of structurally similar 1-substituted heteroaryl fluorene derivatives were prepared in a simple single step reaction, oxidized to fluorenones and then both, fluorenes and fluorenones, were methylated to enhance the solubility and increase the affinity to DNA/RNA. Interactions of both, fluorene and fluorenone analogs with various ds-DNA, ds-RNA revealed strong ds-DNA/RNA binding, and various thermal stabilization effects. Most intriguingly, some fluorene derivatives showed opposite fluorescence change (increase for ds-RNA and decrease for ds-DNA), which was not previously reported for any fluorene analog. CD experiments along with other methods support ds-DNA minor groove binding and major groove ds-RNA binding. All compounds showed negligible interaction with G-quadruplex DNA. Very low cell cytotoxicity of studied compounds combined with very efficient cellular uptake makes these fluorescent dyes safe for laboratory applications. Moreover, especially compounds which show opposite fluorescence response to ds-DNA and ds-RNA, are promising lead compounds for further studies aimed toward ds-RNA-specific fluorescence markers. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to fluorene fluorenone binding dsdna dsrna fluorescent probe, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Application of 2510-01-2

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Goud, S. Banuprakash; Guin, Soumitra; Prakash, Meher; Samanta, Sampak published an article in 2022, the title of the article was Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles.Category: nitriles-buliding-blocks And the article contains the following content:

A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly substituted biol. relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety, e.g., I with satisfactory yields is reported. This method involves cyclic sulfamidate imines, e.g., benzo[e][1,2,3]oxathiazine 2,2-dioxide as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles, e.g., 2-(1-phenylethylidene)malononitrile as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C-N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method’s practicability and allowing for a wide range of substrates with excellent functional group tolerance. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to hydroxyaryl aminonicotinonitrile preparation, cyclic sulfamidate imine vinyl malononitrile domino vinylogous mannich cycloaromatization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: nitriles-buliding-blocks

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On January 31, 2006, Zahouily, Mohamed; Bahlaouan, Bouchaib; Abrouki, Younes; Salah, Mohamed; Bahlaouan, Ouafa; Rayadh, Ahmed; Aadil, Mina; Sebti, Said published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Natural phosphate and potassium fluoride doped natural phosphate as new catalysts for the Vilsmeier-Haack type reaction. And the article contained the following:

The catalytic activity of the inexpensive natural- or potassium fluoride doped- phosphates as bases was evaluated in a Vilsmeier-Haack type reaction. High efficiency, in term of chem. yields and reaction rates was found in the preparation of 2-chlor-3-cyanopyridines starting from 2-propylidene-malononitriles. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to propylidene malononitrile vilsmeier haack reaction natural phosphate catalyst, pyridine chlor cyano preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On January 24, 2020, Zhuo, Junrui; Yuan, Weicheng; Zhao, Jianqiang; Quan, Baoxue; Du, Anni; Wang, Keke published a patent.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Polycyclic heterocyclic compound synthesized using water as medium, its preparation method, and application. And the patent contained the following:

A simple and environmentally-friendly method of preparing a polycyclic heterocyclic compound having improved air-stability, suitability for wide application in photoluminescence materials, drug screening and pharmaceutical industry, and mild reaction conditions is provided. The polycyclic heterocyclic compound is represented by Formula I, where X is O, S, and N-R, Y is H, CH2, OCH2, (CH2)2, (CH2)3, and Ar is alkyl, halogen or aryl-substituted benzene ring, furan ring, thiophene ring, and R1 is hydrogen, alkyl, halogen, and aryl group. The preparation method of the polycyclic heterocyclic compound comprises: using water as a reaction medium and under the regulation of a base, adding dicyanoolefin synthesizer and 2-nitroheteroarom. or 3-nitroheteroarom. hydrocarbon and performing alkali-promoted [4+2] olefin cyclization reaction to obtain the final product. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to polycyclic heterocyclic compound synthesis water medium, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On November 6, 2003, Moeller, Hinrich; Oberkobusch, Doris; Hoeffkes, Horst published a patent.HPLC of Formula: 2510-01-2 The title of the patent was Hair dyes containing isatin derivatives. And the patent contained the following:

The invention concerns hair dyes that contain isatin derivatives and that can be used with or without oxidation agents to color hair; the derivatives are bis-isatin compounds and mols. including isatin coupled to 1H-pyrrol-2,3-dione via an aromatic group. The hair dye compositions can further include dyes that are primary or secondary amines, hydroxydes of aromatic and N-heterocyclic compounds, amino acids and carboxylic acids. Direct dyes can be added; hydrogen peroxide is the used oxidation agent; anionic, zwitterionic and nonionic surfactants are included. Thus 5 mmol (1H,6H)-2,3,7,8-Tetrahydropyrrolo[2’3′: 1,2]-naphtho[5,6-b]pyrrolo-2,3,7,8-tetrone and 5 mmol 3-amino-2-methylamino-6-methyoxypyridine were each suspended in 25 mL water at 50°C. After cooling to 30°C the suspensions were mixed; 5 mmol sodium acetate, one drop of 25 % fatty ether sulfate solution were added and pH 9 was adjusted with diluted sodium hydroxide. The dye mixture was applied to hair; a dark brown color was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to hair dye isatin derivative aromatic n heterocyclic amine hydroxide, Essential Oils and Cosmetics: Hair Preparations and other aspects.HPLC of Formula: 2510-01-2

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On April 10, 2003, Moeller, Hinrich; Oberkobusch, Doris published a patent.HPLC of Formula: 2510-01-2 The title of the patent was Hair dyes containing aromatic or heteroaromatic aldehydes and ketones in combination with other dyes and color intensifiers. And the patent contained the following:

The invention concerns hair dyes that contain aromatic or heteroaromatic aldehydes and ketones and 4-aminopyrazoline-5-one derivatives Further components are selected from the group of primary and secondary aromatic amines, hydroxydes, nitrogen-containing heterocycles, amino acids etc. Thus in a dyeing experiment 5 mmol 4-formyl-1-methylpyridinium benzene sulfonate and 5 mmol 4-aminoantipyrine were mixed and pH 6 was set with sodium hydroxide; an intensive gold-yellow color was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to hair dye aromatic heteroaromatic aldehyde ketone aminoantipyrine, Essential Oils and Cosmetics: Hair Preparations and other aspects.HPLC of Formula: 2510-01-2

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Koeckritz, Peter; Sattler, Ruth; Liebscher, Juergen published an article in 1985, the title of the article was Iminoformylation reaction of substituted crotononitriles. I. Synthesis of new N,N-disubstituted 4-amino-1,1-dicyanobuta-1,3-dienes.Product Details of 2510-01-2 And the article contains the following content:

Condensation of H2CRCR1:C(CN)2 [R = H, Me; R1 = e.g. Et, Ph, 2-thienyl; RR1 = e.g. (CH2)4] with R2R3NH [R2 = alkyl, Ph; R3 = R2, PhCH2, cyclohexyl; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2] and (EtO)3CH in the presence of carboxylic acids as catalysts gave ∼70 title compounds R2R3NCH:CRCR1:C(CN)2 in moderate to good yields depending on steric conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

The Article related to crotononitrile iminoformylation orthoformate amine, carboxylic acid iminoformylation catalyst, butadiene aminodicyano, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Product Details of 2510-01-2

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