Category: 2469-99-0

Related Products of 2469-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2469-99-0 name is 3-Oxobutanenitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Porphyrin 16 (40mg, 0,026mmol) and 2-cyanoacetic acid 10 (10mg, 0.11mmol) were dissolved in a THF solution (5mL). Then, piperidine (8muL) was added and the reaction mixture was heated at 65C for 24 h under N2. The resulting solution was evaporated to dryness under vacuum. Finally, the crude residue was purified by column chromatography over silica gel using CH2Cl2/MeOH as an eluent (in a 98:2 ratio) to obtain ZnP-3DoH-CNCOOH in 78% yield (28mg). 1H NMR (500 MHz, CDCl3): delta=8.83 (d, J=3.7Hz, 2H), 8.78 (sb, 4H), 8.72 (d, J=4.2Hz, 2H), 8.24 (d, J=6.9Hz, 2H), 7.64 (m, 5H), 6.97 (m, 6H), 3.79 (m, 12H), 0.92 (m, 12H), 0.50 (m, 36H), 0.27 (m, 18H) ppm. MS (MALDI-TOF): calcd. for C84H102N5O8Zn [M + H]+ 1372.7020; found 1372.701. UV-Vis in THF [lambdamax/nm (epsilon/mM-1 cm-1)]: 422 (399.7), 550 (16.6).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxobutanenitrile, and friends who are interested can also refer to it.

Reference:
Article; Nikolaou, Vasilis; Charisiadis, Asterios; Chalkiadaki, Sofia; Alexandropoulos, Ioannis; Pradhan, Sourava C.; Soman, Suraj; Panda, Manas K.; Coutsolelos, Athanassios G.; Polyhedron; vol. 140; (2018); p. 9 – 18;,
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Electric Literature of 2469-99-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2469-99-0 as follows.

To a stirring suspension of 5-hydrazinylisoqui- noline (prepared from Example 25 step a, 0.60 g, 3.8 mmol) and 3-oxobutanenitrile (0.31 g, 3.8 mmol) in ethanol (3 mE) was heated at 80 C. for 2 h. After cooling to room temperature, the reaction mixture was in vacuo and the resulting crude residue was purified by flash chromatography (Si02, 0-20% methanol in ethyl acetate) to give the desired product (0.067 g, 2.8 mmol, 73%)

According to the analysis of related databases, 2469-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ChemoCentryx, Inc.; Cappel, Markus; (83 pag.)US2018/9797; (2018); A1;,
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Reference of 2469-99-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2469-99-0 as follows.

General procedure: A mixture of(tetrahydropyran-4-yl)hydrazine (2.32 g, 20 mmol), 3-oxobutyronitrile (1.66 g, 20 mmol) in ethanol (50 mL) was stirred at 90 C for overnight. The reaction was cooled to room temperature and was concentrated. The residue was purified by flash HPLC(MeCN / H20 = 5/100 to 95/100) to afford the desired product 5-methyl-2-(tetrahydropyran-4-yl)-2H-pyrazol-3-ylamine (2.6 g yield: 72%) as white solid. MS: m/z 182.3 (M+H).

According to the analysis of related databases, 2469-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; HASSIG, Christian, A.; JACKSON, Michael, R.; ARDECKY, Robert, John; PASS, Ian; (436 pag.)WO2016/123392; (2016); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2469-99-0, name is 3-Oxobutanenitrile, A new synthetic method of this compound is introduced below., Safety of 3-Oxobutanenitrile

General procedure: In a 250 mL RBF, 3-aminobut-2-enenitrile (2.0 g, 0.24 mole) was added to a stirred solution of cyclohexyl hydrazine hydrochloride (4.0 g, 0.026 mole) and acetic acid (0.1 mL) in ethanol (60 mL). The reaction was refluxed for 6 h. Crude was evaporated and loaded on column to elute out product at 40% ethyl acetate in hexane. (1.74 g, 40%)

The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharma, Swagat; Kozek, Krystian A.; Abney, Kristopher K.; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; David Weaver; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 791 – 796;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2469-99-0, name is 3-Oxobutanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H5NO

3-Oxobutyronitrile (5.04, 1.05 eq) and potassium t-butoxide (7 g, 1.05 eq) were added to DMSO (80 mL).Stir at room temperature for 10 minutes, add (E)-3-penten-2-one (5 g, 1 eq), stir at room temperature for half an hour.Further potassium t-butoxide (7 g, 1.05 eq) was added, and after 1 hour, it was stirred with air overnight. The reaction solution was cooled to 0 C.Diluted with 20 ml of water, 4N HCl (15 ml) was added dropwise, stirred for 15 minutes, filtered to give a solid, which was washed with 100 ml of water to give product g (3.8 g).No further purification is required.

The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Hefei Matter Sciences Institute; Liu Qingsong; Liu Jing; Lv Fengchao; Hu Chen; Wang Wenliang; Wang Aoli; Qi Ziping; Liang Xiaofei; Wang Wenchao; Ren Tao; Wang Beilei; Wang Li; (56 pag.)CN108314677; (2018); A;,
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Application of 2469-99-0, A common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, molecular formula is C4H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: DDQ (341 mg, 1.5 mmol) was added to -cyanoketone (0.5 mmol) in ethyl acetate (2 mL). Theresulting reaction mixture was stirred overnight during which time a yellow solid precipitated.Ethyl acetate (30 mL) was added and the resultant mixture was subsequently washed with coldaqueous 5% NaHCO3 (10 mL×3) and brine. Silica gel (0.5 g) was added and the mixture rotaryevaporated. The resulting powder was added to the top of a short silica-gel column and purifiedusing petroleum ether/ethyl acetate in a 10:1~7:1 ratio (volume ratio) as the eluent to afford thedesired product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Jiang-Sheng; Xue, Yuan; Li, Zhi-Wei; Liu, Wei-Dong; Lu, Cui-Hong; Zhao, Pei-Xia; Synlett; vol. 24; 15; (2013); p. 2003 – 2005;,
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Related Products of 2469-99-0, The chemical industry reduces the impact on the environment during synthesis 2469-99-0, name is 3-Oxobutanenitrile, I believe this compound will play a more active role in future production and life.

General procedure: In a 250 mL RBF, 3-aminobut-2-enenitrile (2.0 g, 0.24 mole) was added to a stirred solution of cyclohexyl hydrazine hydrochloride (4.0 g, 0.026 mole) and acetic acid (0.1 mL) in ethanol (60 mL). The reaction was refluxed for 6 h. Crude was evaporated and loaded on column to elute out product at 40% ethyl acetate in hexane. (1.74 g, 40%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Oxobutanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sharma, Swagat; Kozek, Krystian A.; Abney, Kristopher K.; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; David Weaver; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 791 – 796;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2469-99-0, name is 3-Oxobutanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2469-99-0, Safety of 3-Oxobutanenitrile

In a 250 mL RBF, 3-aminobut-2-enenitrile (2.0 g, 0.24 mole) was added to a stirred solution of cyclohexyl hydrazine hydrochloride (4.0 g, 0.026 mole) and acetic acid (0.1 mL) in ethanol (60 mL). The reaction was refluxed for 6 h. Crude was evaporated and loaded on column to elute out product at 40% ethyl acetate in hexane. (1.74 g, 40%) LCMS: RT = 1.50 min., >98% 215 and 254 nm, m/z = 180.1 [M + H]+. 1H NMR (499 MHz, DMSO) delta 5.02 (s, 1H), 4.92 (s, 2H), 3.86 – 3.78 (m, 1H), 1.94 (s, 3H), 1.78 – 1.68 (m, 4H), 1.63 (dd, J = 16.3, 7.4 Hz, 3H), 1.31 (q, J = 12.9 Hz, 2H), 1.18 – 1.08 (m, 1H). 13C NMR (126 MHz, DMSO) delta 145.90, 144.64, 87.80, 53.50, 32.13, 25.21, 25.05, 14.02.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxobutanenitrile, and friends who are interested can also refer to it.

Reference:
Article; Sharma, Swagat; Kozek, Krystian A.; Abney, Kristopher K.; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; David Weaver; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 791 – 796;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 2469-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2469-99-0 name is 3-Oxobutanenitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1. 2-(2-Chlorobenzyl)-3-oxobutanenitrile Into a 250-mL 3-necked round-bottom flask, was placed ethanol (100 mL). This was followed by the addition of Na (1.72 g, 74.78 mmol, 1.50 equiv) in several batches. The reaction was refluxed until the Na dissolved. To this was added a solution of 3-oxobutanenitrile (4.15 g, 50.00 mmol, 1.00 equiv) in ethanol (20 mL) dropwise with stirring, while the temperature was maintained at reflux. The reaction was refluxed for 1 h. Then, a solution of 1-(bromomethyl)-2-chlorobenzene (10.25 g, 50.00 mmol, 1.00 equiv) in ethanol (20 mL) was added dropwise with stirring, while the temperature was maintained at reflux. Refluxing continued for 2 hrs. Then the reaction was cooled to room temperature, concentrated to dryness and then suspended between water and ether. The aqueous layer was separated and extracted with ether. The aqueous layer was acidified with 3N HCl to pH<6 and extracted with EA. The organic layer was dried over Na2SO4, filtered and concentrated to dryness. The residue was chromatographed (PE:EA=1:50) to get 2.9 g (27%) of 2-(2-chlorobenzyl)-3-oxobutanenitrile as a colorless oil. At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxobutanenitrile, and friends who are interested can also refer to it. Reference:
Patent; BIOENERGENIX; US2012/277224; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 2469-99-0,Some common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, molecular formula is C4H5NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirring suspension of quinolin-5-yl-hydrazine (0.25 g, 1.6 mmol) in 3:1 ethanol/deionized water (2.5 mL) was added 3-oxo-butyronitrile (0.13 g, 1.6 mmol). The reaction mixture was then heated at 60 C. for 2 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo and the resulting crude product was used directly without further purification (0.21 g, 1.5 mmol, 94%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Oxobutanenitrile, its application will become more common.