Category: 236750-65-5

Related Products of 236750-65-5, These common heterocyclic compound, 236750-65-5, name is 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 4 ml 5-neck flask was charged with 2.96 g (10 mmol) of 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile, 38.4 mg (0.3 mmol) of molybdenum dioxide, and 0.12 g of activated carbon. 30 ml of absolute ethanol was added dropwise to a solution of hydrazine hydrate (80%) at a temperature of 1.88 g (30 mmol). After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to near dryness, slurried with petroleum ether to give 2.4g desired product as a pale yellow solid, yield 90.2%, HPLC purity 99%.

The synthetic route of 236750-65-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Puji Bio-technology (Taizhou) Co., Ltd.; Jia Qiang; Ma Chi; Ma Tianhua; Yang Zhengwei; (11 pag.)CN109574853; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 236750-65-5, name is 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C13H16N2O6

(d) 2-amino-4, 5-bis (2-methoxyethoxy) benzonitrile:; To 4,5-bis (2-methoxyethoxy)-2-nitrobenzonitrile(10 g) was added acetic acid (75ml) and water(75ml), stirred the reaction mass for about 10 min, added Iron powder (7g) in portions over a period of 2hrs, Stirred the reaction mixture for about Vz hr at 300C adjusted PH of the reaction mass to 7. Extracted the material into ethylacetate, the organic layer was dried over sodium sulfate and concentrated to yield crystalline yellow solid. Which was further recrystallized from methanol (6g) mp 74-77 0C1HNMR (CDCI3): delta 3.43(s, 6H), 3.73(m, 4H), 4.08(m, 4H), 4.20(brs, 2H), 6.25(s, 1 H), 6.90(s, 1 H)

The synthetic route of 236750-65-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION; WO2007/138612; (2007); A2;; ; Patent; VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION; WO2007/138613; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts