Category: 2338-76-3

Adding a certain compound to certain chemical reactions, such as: 2338-76-3, name is 3-(Trifluoromethyl)phenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2338-76-3, COA of Formula: C9H6F3N

A suspension of 56 g of sodium hydride at a concentration of 60percent in oil in 750 ml of DMSO and 250 ml of THF is admixed dropwise under an inert atmosphere and at AT with a solution of 120 g of 3-(trifluoromethyl)phenylacetonitrile in 250 ml of DMSO and then, slowly with a solution of 150 g of the compound obtained in the preceding step in 250 ml of DMSO and heated at 60° C. overnight. The reaction mixture is poured into an ice/H2O mixture and extracted with ether, the organic phase is washed with water and with saturated NaCl solution and dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is chromatographed on silica gel, eluting with DCM and then with a DCM/AcOEt (80/20; v/v) mixture. This gives 191 g of the expected product, which crystallizes; m.p.=72-73° C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)phenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; sanofi-aventis; US2005/176722; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 2338-76-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2338-76-3, name is 3-(Trifluoromethyl)phenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-(3-(trifluoromethyl)phenyl)acetonitrile (3.000 g, 16.203 mmol) and sodium hydride (60.00percent, 1.426 g, 35.647 mmol) in N,N-dimethylformamide (100 mL) at 0 ¡ãC, After the addition of 1,3-dibromopropane (1.731 mL, 16.203 mmol) this mixture was stirred at room temperature for 17 hours, a saturated aqueous solution of sodium bicarbonate (10 mL) was added to the reaction mixture at room temperature and the reaction was stirred for 10 minutes. The solvent was removed from the reaction mixture under reduced pressure, the obtained concentrate was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 0percent to 5percent) and concentrated to give the title compound (0.945 g, 25.9percent) as a colorless oil.

The synthetic route of 3-(Trifluoromethyl)phenylacetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts