Category: 2286-54-6

Related Products of 2286-54-6, A common heterocyclic compound, 2286-54-6, name is 3,3-Diphenylpropanenitrile, molecular formula is C15H13N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Gaseous hydrogen chloride was bubbled through a solution of 35.8 g (0.185 mol) of 3,4,5-trimetoxy-benzonitrile and 15 mL of anhydrous ethanol in 150 mL of diethyl ether cooledto 0-5C until a gain in weight of 8 g. The mixture was kept for 48 h at 3-5C, and the precipitate was filtered off and washed with diethyl ether (3 × 20 mL). Yield of 1a hydrochloride 45.7 g (89%). The product was mixed with 100 mL of water and 150 mL of diethyl ether, the mixture was cooled to 4-8C, and 15 g of sodium hydrogen carbonate was added with stirring. The mixture was stirred for 10 min, the organic phase was separated and dried over anhydrous sodium sulfate, and the solvent was distilled off. Yield 38g (85%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Khromova, N. Yu.; Fedorov; Malekin; Kutkin; Russian Journal of Organic Chemistry; vol. 52; 10; (2016); p. 1490 – 1495; Zh. Org. Khim.; vol. 52; 10; (2016); p. 1497 – 1502,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 2286-54-6, A common heterocyclic compound, 2286-54-6, name is 3,3-Diphenylpropanenitrile, molecular formula is C15H13N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box, 0.01 mmol of nickel chloride was added, 0.52 mmol of diphenylphosphine oxide, 1.5 equivalents of t-BuOK (potassium tert-butoxide),Add to the Schlenk reaction tube in turn, then Add 0.4mmol 1, 1-diphenylpropionitrile compound, Vacuum and backfill nitrogen; under a nitrogen atmosphere, add 3 ml of 1,4-dioxane to the solvent. The reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. That is the target product: 1,1-diphenylethyldiphenylphosphine oxide, yield 87%.

The synthetic route of 2286-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunan University; Zhang Jishu; Qi Tafamingrenqingqiubugongkaixingming; (13 pag.)CN109438512; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2286-54-6, name is 3,3-Diphenylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,3-Diphenylpropanenitrile

A solution of hydroxylamine hydrochloride (38.6 ml, 38.6 mmol) in MeOH was added to a solution of potassium hydroxide (38.6 ml, 38.6 mmol, Eq: 4) in MeOH at 0 C. The resulting mixture was filtered and the filtrate was added to a 150 mL round-bottomed flask containing 3,3-diphenylpropanenitrile (2 g, 9.65 mmol). The mixture was heated at reflux for 16 h, cooled and evaporated to dryness. The residue was dissolved in EtOAc, washed with brine, dried (MgSO4) and evaporated to dryness. The crude product was dissolved in CHCl3 (50 ml), treated with dimethyl but-2-ynedioate (1.65 g, 11.6 mmol, Eq: 1.2) and heated at reflux for 1 h and then evaporated to dryness. The residue was dissolved in xylene (10 ml), heated at 120 C. in a microwave oven for 4 h and evaporated to dryness. Chromatography (80 g SiO2; 20 to 100% EtOAc in hexanes) gave the title product as an off-white solid (0.42; 12%). LCMS: m/z=348.9 (MH+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2286-54-6.