Category: 228421-83-8

Application of 228421-83-8, These common heterocyclic compound, 228421-83-8, name is 3,5-Difluoro-4-(hydroxymethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an ice-cold solution of 3,5-difluoro-4-(hydroxymethyl)benzonitrile (250 mg; 1.48 mmol) [CAS 228421-83-8] in dichlormethane (10 mL) was added phosphorus tribromide (0.07 mL; 0.74 mmol). The mixture was stirred at 0 C for 3 hours. The mixture was deactivated by water and diluted with dichloromethane (10 mL). The mixture was washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over anhydrous Na2S04, filtered and concentrated to dryness to afford 4- (bromomethyl)-3,5-difluoro-benzonitrile (187 mg) as a white solid. ‘H-NMR (400 MHz, CDC13) delta ppm: 7.27 (s, 1H), 7.25 (s, 1H), 4.50 (s, 2H).

Statistics shows that 3,5-Difluoro-4-(hydroxymethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 228421-83-8.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; LANE, Heidi; RICHALET, Florian; EL SHEMERLY, Mahmoud; (169 pag.)WO2018/2220; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 228421-83-8, A common heterocyclic compound, 228421-83-8, name is 3,5-Difluoro-4-(hydroxymethyl)benzonitrile, molecular formula is C8H5F2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an ice cooled solution [OF 2, 6-DIFLUORO-4-HYDROXYMETHYLBENZONITRILE] (1.24 g, 7.32 mmol; see step (iii) above) and methanesulfonyl chloride (0.93 g, 8.1 mmol) in 60 mL of methylene chloride was added triethylamine (0.81 g, 8.1 mmol) with stirring. After 3 h at [0C,] the mixture was washed twice with 1M HCI and once with water, dried [(NA2SO4)] and evaporated. The product could be used without further purification. Yield: 1.61 g (89%). ‘H NMR (300 MHz, [CDCI3)] [5] 7.29 (m, 2H), 5.33 (s, 2H), 3.07 (s, 3H)

The synthetic route of 228421-83-8 has been constantly updated, and we look forward to future research findings.