Category: 22364-68-7

Reference of 22364-68-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22364-68-7, name is 2-(o-Tolyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Part A Preparation of ethyl 2-(alpha-cyano-2′-methylphenylacetyl)cyclohexyl carboxylate Using the procedure described in Example I, Part A, and starting with 159.80 g (0.700 mol) of diethyl 1,2-cyclohexanedicarboxylate, 61.65 g (0.47 mol) of 2-methylbenzyl cyanide, 14.06 g (0.61 mol) of sodium, and 250 ml of ethanol, 87.74 g (60% yield) of the desired cyano keto ester was obtained as a red, viscous oil.

The chemical industry reduces the impact on the environment during synthesis 2-(o-Tolyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Application of 22364-68-7, These common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The general procedure of the CuI catalyst based synthesis method of carbazole derivatives 3 to 8 was as follows: 50 mL two-necked round flasks dried in an oven were charged with nitrosinenamaldehyde (0.5 mmol) or nitrochalcone (0.5 mmol). ,1.0 mmol of benzyl cyanide and 5 mol% CuIdissolved with Cs2CO3(1 equiv)dissolved in 5 mL THFwere added.Each reaction mixture was then refluxed for 6-10 hours until the reaction shown by TLC at open air conditions was complete.The solvent was then removed using a rotary evaporator under reduced pressure to give a residue.The residue was purified by flash column chromatography using silica gel to separate the pure product.

The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.

Reference of 22364-68-7,Some common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, molecular formula is C9H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzonitrile (103 mg, 1 mmol) and sodium azide (97.5 mg, 1.5 mmol) were dissolved in 2 ml of dry DMF in a 25 ml round bottom flask. PbCl2 (27.8 mg, 0.1 mmol, 10 mol %) was added to the reaction mixture and stirred at 120 C for 8 h under nitrogen. After completion of the reaction (as monitored by TLC), the reaction mixture was cooled to room temperature and 10 ml of ice water was added followed by addition of 3 N HCl until the reaction mixture became strongly acidic (pH 2-3). The reaction mixture was extracted three times with 20 ml ethyl acetate. The organic layer was washed with brine solution and dried over anhydrous sodium sulfate, and was evaporated under reduced pressure to give a white solid product of 5-phenyl 1H-tetrazole with 81% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(o-Tolyl)acetonitrile, its application will become more common.

Reference:
Article; Kant, Rama; Singh, Vishal; Agarwal, Alka; Comptes Rendus Chimie; vol. 19; 3; (2016); p. 305 – 312;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22364-68-7, name is 2-(o-Tolyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H9N

Add dichloroethane (60g),Potassium hydroxide (0.15mol, 9.6g, content 90%),After stirring, the temperature was lowered to 15 C, and o-methylphenylacetonitrile (0.1 mol, 13.1 g) was added in one portion. Isoamyl nitrite (0.16mol, 18.7g) was added dropwise to the system, and after holding for 1 hour after the completion of the infiltration, 2-methyl-a-cyanobenzoxime potassium was obtained by suction filtration and dried. The yield was 96 %, The content is 93.5%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 22364-68-7.

Reference:
Patent; Jingbo Agrochemical Technology Co., Ltd.; Wang Shuaishuai; Cao Tongbo; Wang Xiangchuan; Li Hongxia; Cheng Guohua; Wang Jiangang; Ma Falu; Yu Lianyou; Wang Xue; (12 pag.)CN110396054; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 22364-68-7, A common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, molecular formula is C9H9N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part A: Preparation of ethyl 2-(alpha-cyano-2′-methylphenylacetyl)cyclohexyl carboxylate Using the procedure described in Example I, Part A, and starting with 159.80 g (0.700 mol) of diethyl 1,2-cyclohexanedicarboxylate, 61.65 g (0.47 mol) of 2-methylbenzyl cyanide, 14.06 g (0.61 mol) of sodium, and 250 ml of ethanol, 87.74 g (60% yield) of the desired cyano keto ester was obtained as a red, viscous oil.

The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Union Carbide Corporation; US4283348; (1981); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts