Category: 222801

On October 19, 2018, Cao, Dongdong; Ying, Anguo; Mo, Hanjie; Chen, Dingben; Chen, Gang; Wang, Zhiming; Yang, Jianguo published an article.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was [4 + 2] Annulation of 3-Nitroindoles with Alkylidene Malononitriles: Entry to Substituted Carbazol-4-amine Derivatives. And the article contained the following:

A general and transition-metal-free method for the construction of the carbazol-4-amine motif via a vinylogous Michael addition/cyclization/isomerization/elimination reaction of 3-nitroindoles with alkylidene malononitriles has been developed. This novel methodol. allows the facile synthesis of a series of di- and trisubstituted carbazol-4-amine derivatives in moderate to good yields. A gram-scale experiment was successfully performed, highlighting the practicability of this method. Moreover, this strategy is also applicable to 3-nitrobenzothiophene, affording the corresponding dibenzo[b,d]thiophen-1-amine derivatives in moderate yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to nitroindole alkylidene malononitrile vinylogous michael addition cyclization isomerization elimination, carbazolamine preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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Nitrile – Wikipedia,
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Zhu, Yi; Li, Yao; Meng, Qingbin; Li, Xin published an article in 2016, the title of the article was An organocatalytic enantioselective vinylogous Mannich reaction of 伪,伪-dicyanoolefins with isatin N-Boc ketimines.Related Products of 2510-01-2 And the article contains the following content:

The first catalytic enantioselective vinylogous Mannich reaction of 伪,伪-dicyanoolefins with ketimines derived from isatins was developed. High yields and enantioselectivities were observed for the reaction of various ketimines and 伪,伪-dicyanoolefins using a tert-Bu substituted cinchona alkaloid type squaramide catalyst. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to dicyanoolefin ketimine chiral squaramide catalyst mannich reaction, dicyano phenylallyl oxoindolinyl carbamate enantioselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 2510-01-2

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On February 20, 1985, Koeckritz, Peter; Liebscher, Alexander published a patent.Computed Properties of 2510-01-2 The title of the patent was N,N,1,2,3-Pentasubstituted 4-amino-1-cyano-1,3-butadiene. And the patent contained the following:

R2R3NCH:CR1CR:CXCN [R,R1 = alkyl, aryl; RR1 = (CH2)n (n = 3-5); R2, R3 = alkyl, aryl; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH)2; X = CN, carbonyl such as acyl, alkoxycarbonyl, H2NCO, NO2, aryl], useful as synthons for pharmaceuticals were prepared by reaction of R1CH2CR:CXCN with HC(OR4)3 (R4 = alkyl) and HNR2R3 in the presence of acidic condensation agent by 8 methods. A mixture of 2-O2NC6H4CO2H and 0.01 mol HNPhMe was treated with 0.015 mol HC(OEt)3 and 0.01 mol Me2C:C(CN)2 and the mixture refluxed 30 min. to give 65% MePhNCH:CHCMe:C(CN)2. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to aminocyanobutadiene pharmaceutical synthon, cyanobutadiene amino pharmaceutical synthon, butadiene aminocyano pharmaceutical synthon, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Computed Properties of 2510-01-2

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On August 30, 2019, Yalcin, Ergin; Duyar, Halil; Cakmaz, Deniz; Sahin, Ertan; Seferoglu, Zeynel published an article.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was The synthesis of blue emitting 3-Amino-1-hetarylfluorenes and their unprecedented alkylated derivatives. And the article contained the following:

Novel 3-Amino-1-hetarylfluorene derivatives have medicinal uses and challenging transformation in organic synthesis have been synthesized via decyanation process. Surprisingly, the alkylated compounds derived from 3-Amino-1-hetarylfluorenes were obtained via further nucleophilic substitution to the 9-C and 3-N positions of the fluorene ring because of the harsh reaction condition employed. The synthesized compounds were characterized by spectroscopic techniques as well as X-ray single crystal diffraction anal. This new family of blue emitting fluorene derivatives have low to moderate quantum yields (the largest value of 蠁F = 0.52 for compound 15). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to amino heteroaryl blue emitting fluorescent dye preparation photophys property, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Fluorescent Brighteners and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On June 2, 2022, Hilf, Justin A.; Rose, Tristin E.; Bartberger, Michael D.; O’Boyle, Brendan M.; Reeves, Corey M.; Loson, Oliver C.; Stoltz, Brian M.; McDermott, Martina; O’Brien, Neil A.; Slamon, Dennis published a patent.COA of Formula: C12H8N2 The title of the patent was Preparation of substituted N-(spiro[indene-2,7′-quinazolin]-4′-yl)piperazines as Kras G12C inhibitors. And the patent contained the following:

The invention relates to compounds I [x1 = C(O) or C(R1)(R2); x2 = a bond, CO, O, etc.; y1b and y1c = independently C=CH2, CO, O, S, etc.; z1-z4 = independently C and N; R1 and R2 = independently H and F; R3 = independently H, (halo)alkyl; R4-R7 = independently H, F, Cl, Me, etc., R8a = H, alkyl, cycloalkyl, etc.; R8b = H, CN, halo, etc.; with the provisons], and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds I are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation. E.g., a multi-step synthesis of II鈥FA, starting from 5,6,7,8-tetrahydroquinazoline-2,4-diol, was described. Exemplified compounds I were tested for their KRAS G12C inhibitory activity (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).COA of Formula: C12H8N2

The Article related to spiroindenequinazolinylpiperazine preparation kras protein g12c mutation inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C12H8N2

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On September 30, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Son, Young-A. published an article.Related Products of 2510-01-2 The title of the article was Optical properties of donor-蟺-(acceptor)n merocyanine dyes with dicyanovinylindane as acceptor group and triphenylamine as donor unit. And the article contained the following:

Donor-蟺-(Acceptor)n (D-蟺-A) type dyes were synthesized and their absorption and emission spectra investigated in different solvents. Strong acceptor units imparted large red-shifts in absorption; the twisting of the dye’s structure imposed by an acceptor unit quenched fluorescence. Electron delocalization before and after excitation was observed according to MO calculations The results indicated potential use of the dyes as electro-optical materials. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to merocyanine dye fluorescence solvatochromism optical, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Methines and Polymethines and other aspects.Related Products of 2510-01-2

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On June 11, 1999, Asiri, Abdullah Mohamed published an article.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Synthesis and characterization of dyes exemplified by 2-arylidene-1-dicyanomethyleneindane. And the article contained the following:

The synthesis of methine dyes formed by Knoevenagel condensation of aromatic aldehydes with 1-(dicyanomethylene)indan afforded a novel series of dyes absorbing in the region 490-593 nm. Substituents on the aromatic aldehyde moiety had a significant effect on the visible absorption maxima of the dyes; increasing the solvent polarity also had a pronounced effect on the absorption maxima. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to arylidenedicyanomethylindan cyanine dye preparation spectra, indan derivative methine dye preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Methines and Polymethines and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On September 30, 1993, Aadil, M.; Kirsch, G. published an article.Application of 2510-01-2 The title of the article was Synthesis of new 3-aminothieno- and -selenolo[2,3-b]pyridines. And the article contained the following:

Cyclization of alkylidenemalonitriles by the Vilsmeier-Haack reagent gives 2-chloro-3-cyanopyridines, e.g., I. These compounds are used as starting material for the synthesis of thieno[2,3-b]- and selenolo[2,3-b]pyridines, e.g., II (X = S, Se). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to vilsmeier haack cyclization alkylidenemalonitrile, chlorocyanopyridine, selenolopyridine, thienopyridine, Organometallic and Organometalloidal Compounds: Groups Iva, Va, Via – Ge, Sn, Pb, As, Sb, Bi, Se, Te, Po and other aspects.Application of 2510-01-2

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On November 30, 2001, Asiri, Abdullah Mohamed published an article.Synthetic Route of 2510-01-2 The title of the article was Organometallic dyes: Part 1. Synthesis of orange to cyan dyes based on donor-conjugated-acceptor chromogenes using ferrocene as the donor group. And the article contained the following:

A novel series of organometallic donor-conjugated-acceptor dyes derived from ferrocene as the donor group have been synthesized via the Knoevenagel reaction of ferrocene carboxaldehyde and various active methylene compounds to give a range of dyes ranging from orange to blue-green in color. The most bathochromic dye is that derived from dialkyl thiobarbituric acid and the least is that derived from the tetralone. The dyes showed an unusual neg. solvatochromism as the solvent polarity increased. All dyes synthesized are expected to have some non-linear optical properties, as evidenced from the pronounced solvatochromism. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

The Article related to ferrocene derivative donor acceptor dye preparation solvatochromism, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.Synthetic Route of 2510-01-2

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On March 31, 2000, Asiri, Abdullah Mohamed published an article.SDS of cas: 2510-01-2 The title of the article was Synthesis, characterizations and absorption spectral properties of new styryl dyes derived from 1-dicyanomethyleneindane. And the article contained the following:

The synthesis and the absorption properties of methine dyes formed by the Knoevenagel condensation of aromatic aldehydes with 1-(dicyanomethylene)indan afforded a novel series of dyes absorbing in the region of 490-593 nm. The substituents on the aromatic aldehyde have remarkable effects on the visible absorption maxima of the new dyes. Indole-3-carboxaldehyde gave a blue dye. The introduction of dicyanomethylene group into 1-indanone causes a large bathochromic shift of the visible absorption maxima of the new dyes when compared with the same dye obtained from 1-indanone itself. Steric effects cause even more of a bathochromic shift compared dyes having substituents in the ortho position and the same dyes having the same substituents in the para position. Increasing the solvent polarity had pronounced effects on the absorption maxima. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to styryl dye preparation spectra substituent effect, dicyanomethylenedindan knoevenagel reaction methine dye preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
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