Category: 2182-39-0

Adding a certain compound to certain chemical reactions, such as: 2182-39-0, name is 2-(Phenylamino)propanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2182-39-0, Application In Synthesis of 2-(Phenylamino)propanenitrile

d) 5-[1-Ethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-1H-indol-6-ylmethyl]-pyrimidine-2,4-diamine. This compound was produced from 1-ethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-1H-indole-6-carbaldehyde (630 mg, 1.97 mmol), 2-anilinopropionitrile (324 mg, 2.17 mmol), and guanidine hydrochloride (634 mg, 6.60 mmol), following the procedure detailed in Example 4, step f. Yield: 425 mg (53%). Yellow solid. MS (ISP): 414.4 ([M+H]+)

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Reference:
Patent; Mattei, Patrizio; Pflieger, Philippe; US2003/119857; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 2182-39-0,Some common heterocyclic compound, 2182-39-0, name is 2-(Phenylamino)propanenitrile, molecular formula is C9H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

F. 2-(2-Methoxy-4-methyl-7-quinolylmethyl)-3-anilinoacrylonitrile. To a stirred mixture of 0.65 g (3.20 mM) of 2-methoxy-4-methyl-7-quinolinecarbaldehyde and 0.52 g (3.50 mM) of anilinopropionitrile in 10 mL of dry dimethyl sulfoxide was added in one portion 0.19 g (3.50 mM) of sodium methoxide. The resultant mixture was then heated to 90-95 C. (internal temperature) for 2 h., after which the dimethyl sulfoxide was removed in vacuo. Addition of distilled water to the resultant concentrate resulted in a brown precipitate. This was filtered, washed repeatedly with water and air-dried. Recrystallization from absolute ethanol resulted in 0.49 g (46%) of 2-(2-methoxy-4-methyl-7-quinolylmethyl)-3-anilinoacrylonitrile as a light brown solid: mp 170-172 C. Anal. Calcd. for C21 H19 N3 O: C, 76.57; H, 5.81; N, 12.76. Found: C, 76.34; H, 5.83; N, 12.60.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Phenylamino)propanenitrile, its application will become more common.

Reference:
Patent; Burroughs Wellcome Co.; US4587341; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 2182-39-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2182-39-0 as follows.

EXAMPLE 5 Preparation of N-(2-Propionitrile)-N-phenylcarbamoyl chloride STR11 Phosgene, 23.0 g (0.23 mole) was absorbed in 300 ml methylene chloride. To that stirred solution, a solution of 29.2 g (0.2 mole) 2-(phenylamino)-propionitrile and 15.8 g (0.2 mole) pyridine in 50 ml methylene chloride was dropped in over 30 minutes. Stirring was continued for 5 minutes. The reaction mixture was washed twice with 100 ml ice water and once with 100 ml ice water containing 20 ml concentrated hydrochloric acid, dried over magnesium sulfate and stripped to give 41 g of a brown oil which soon solidified.

According to the analysis of related databases, 2182-39-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chevron Research Company; US4602029; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts