Category: 21667-62-9

Sathiyamoorthi, Sivakumar; Almansour, Abdulrahman I.; Raju, Suresh Kumar; Natarajan, Arumugam; Kumar, Raju Ranjith published the artcile< Imidazolium ylide mediated tandem Knoevenagel-Michael-O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans>, Quality Control of 21667-62-9, the main research area is benzoylacetonitrile benzaldehyde imidazolium ylide multicomponent tandem Knoevenagel Michael heterocyclization; diphenyl benzoyl dihydrofuran carbonitrile preparation diastereoselective.

The diastereoselective syntheses of novel trans aroyldiaryldihydrofurancarbonitriles I [R = H, 4-Me, 3-Cl, 4-Cl, X = H, 2-Cl, 3-Br, etc., Y = H, 4-F, 4-MeO, 4-Cl] have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylides in the presence of Et3N.

Synthetic Communications published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Quality Control of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Kai; Liu, Hao; Hou, Yilin; Shen, Jiefeng; Liu, Delong; Zhang, Wanbin published the artcile< A Pd-catalyzed asymmetric allylic substitution cascade via an asymmetric desymmetrization for the synthesis of bicyclic dihydrofurans>, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is allylic mesodicarbonate oxonitrile palladium catalyst substitution; bicyclic dihydrofuran enantioselective diastereoselective regioselective preparation.

A Pd-catalyzed asym. allylic substitution cascade of allylic meso-dicarbonates with 3-oxo-nitriles was developed for the synthesis of chiral bicyclic dihydrofurans bearing two vicinal carbon stereocenters. The reaction proceeded via an asym. desymmetrization processed with the desired products being obtained in high yields and with up to 97% ee. The reaction was performed on a gram-scale and the corresponding bicyclic dihydrofurans could undergo several transformations. The methodol. provided an efficient synthetic route to biol. active chiral bicyclic dihydrofurans derivatives

Chemical Communications (Cambridge, United Kingdom) published new progress about Bicarbonates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yan, Yingkun; Li, Min; Liu, Min; Huang, Min; Cao, Lianyi; Li, Wenzhe; Zhang, Xiaomei published the artcile< Sc(OTf)3-Catalyzed Dearomative [3+2] Annulation of 5-Aminoisoxazoles with Quinone Imine Ketals or Quinone Monoacetals>, HPLC of Formula: 21667-62-9, the main research area is indoline fused isoxazoline preparation diastereoselective; dihydrobenzofuran fused isoxazoline preparation diastereoselective; aminoisoxazole quinone imine ketal cyclization scandium triflate catalyst; quinone monoacetal aminoisoxazole cyclization scandium triflate catalyst.

Sc(OTf)3-catalyzed dearomative [3+2] annulations of 5-aminoisoxazoles I (R1 = Me, 4-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, Et, 4-bromophenyl, 3-chlorophenyl; R3 = Me, Et) with quinone imine ketals (QIKs) II (R4 = NTs; R5 = H) and quinone monoacetals (QMAs) II (R4 = O; R5 = H, Me, Cl, Br) were reported. A variety of indoline- and 2,3-dihydrobenzofuran-fused isoxazolines III, IV were afforded in moderate to good yields with excellent diastereoselectivities (all cases >20 : 1 dr). This method featured mild reaction conditions, wide substrate scope, and gram-scale synthesis.

European Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, HPLC of Formula: 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Balwe, Sandip Gangadhar; Jeong, Yeon Tae published the artcile< New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence>, Safety of 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is tricyclic benzofuropyrrole preparation; hydroxybenzaldehyde aroylacetonitrile isocyanide cascade addition heterocyclization toluenesulfonic acid catalyst.

The first p-TSA.H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles I (R = t-Bu, Cy; R1 = H, 3-Cl, 3-Me, 4-F; R2 = H, 7-MeO, 7-EtO, 5-Br, 5-Cl) has been discovered. The reaction sequence involves a Knoevenagel condensation of 2-hydroxybenzaldehydes R3-2-HO-C6H3CHO (R3 = H, 3-MeO, 3-EtO, 5-Cl, 5-Br) with aroylacetonitriles R1C6H4C(O)CH2CN followed by subsequent nucleophilic addition of the divalent isocyano carbon to generate highly reactive nitrilium carbon, which could be readily trapped by an adjacent phenolic group of 2-hydroxybenzaldehydes to access diverse benzofuro[2,3-b]pyrroles I in one pot. This approach features a robust one-step protocol with broad substrate scope, good functional group tolerance, and promising application prospects in the synthesis of complex tricyclic N-heterocycles I.

New Journal of Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (aroyl). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Safety of 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Ya-Kai; Wang, Bin published the artcile< Synthesis of α-Ketoamides from β-Ketonitriles and Primary Amines: A Catalyst-Free Oxidative Decyanation-Amidation Reaction>, SDS of cas: 21667-62-9, the main research area is ketoamide preparation; ketonitrile amine decyanation amidation.

AN oxidative decyanation-amidation of β-ketonitriles and primary amines readily occurs using hydrogen peroxide sodium carbonate adduct (Na2CO3·1.5H2O2), K2CO3, and 1,4-dioxane. This reaction affords α-ketoamides under mild conditions without the need of a catalyst.

European Journal of Organic Chemistry published new progress about Amidation. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, SDS of cas: 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Balwe, Sandip Gangadhar; Jeong, Yeon Tae published the artcile< New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence>, Electric Literature of 21667-62-9, the main research area is tricyclic benzofuropyrrole preparation; hydroxybenzaldehyde aroylacetonitrile isocyanide cascade addition heterocyclization toluenesulfonic acid catalyst.

The first p-TSA.H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles I (R = t-Bu, Cy; R1 = H, 3-Cl, 3-Me, 4-F; R2 = H, 7-MeO, 7-EtO, 5-Br, 5-Cl) has been discovered. The reaction sequence involves a Knoevenagel condensation of 2-hydroxybenzaldehydes R3-2-HO-C6H3CHO (R3 = H, 3-MeO, 3-EtO, 5-Cl, 5-Br) with aroylacetonitriles R1C6H4C(O)CH2CN followed by subsequent nucleophilic addition of the divalent isocyano carbon to generate highly reactive nitrilium carbon, which could be readily trapped by an adjacent phenolic group of 2-hydroxybenzaldehydes to access diverse benzofuro[2,3-b]pyrroles I in one pot. This approach features a robust one-step protocol with broad substrate scope, good functional group tolerance, and promising application prospects in the synthesis of complex tricyclic N-heterocycles I.

New Journal of Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (aroyl). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Electric Literature of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Hui; Yan, Yingkun; Zhang, Jiayan; Liu, Min; Cheng, Shaobing; Wang, Zhouyu; Zhang, Xiaomei published the artcile< Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines>, Computed Properties of 21667-62-9 , the main research area is aminoisoxazole quinone monoimine chiral phosphoric acid catalyst dearomative cycloaddition; benzofuroisoxazole diamine preparation enantioselective; quinone monimine aminoisoxazole phosphoric acid tandem dearomative cycloaddition cyclization; epoxyazenometheno dihydrobenzofuropyrrolyl benzenesulfonamide preparation enantioselective.

The first enantioselective dearomative [3+2] annulation of 5-aminoisoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed.

Chemical Communications (Cambridge, United Kingdom) published new progress about [3+2] Cycloaddition reaction catalysts (dearomative, stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Pawan K.; Kumar, Rajiv; Ram, Sita; Chandak, Navneet published the artcile< Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions>, COA of Formula: C9H6ClNO, the main research area is ketonitrile preparation green chem one pot.

A one pot synthesis of β-ketonitriles RC(O)CH2CN (R = 4-bromophenyl, 3,4-dimethoxyphenyl, naphth-1-yl, etc.) and I from readily accessible 3-chloropropenals RCH(Cl)=CHCHO and 3-chloro-3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)prop-2-enal using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for the product synthesis.

Synthetic Communications published new progress about Green chemistry. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Li-Na; Zhang, Shuai-Zheng; Zhang, Wan-Lu; Dong, Yao; Mo, Li-Ping; Zhang, Zhan-Hui published the artcile< Synthesis, characterization and application of magnetic biochar sulfonic acid as a highly efficient recyclable catalyst for preparation of spiro-pyrazolo[3,4-b]pyridines>, Formula: C9H6ClNO, the main research area is cobalt iron oxide biochar sulfonic acid magnetization adsorption stability.

A magnetic biochar sulfonic acid was prepared and characterized by fourier IR spectroscopy (FT-IR), powder x-ray diffraction technol., scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The prepared catalyst exhibited excellent catalytic activity for synthesis of spiro-pyrazolo[3,4-b]pyridine derivatives via one-pot three-component reaction of 1H-pyrazol-5-amine, isatin and 3-oxo-3-phenylpropanenitrile. The catalyst could be readily recovered and reused several times without an obvious decay of catalytic performance.

Research on Chemical Intermediates published new progress about Adsorption. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeng, Ge; Liu, Jichao; Shao, Yinlin; Zhang, Fangjun; Chen, Zhongyan; Lv, Ningning; Chen, Jiuxi; Li, Renhao published the artcile< Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles>, COA of Formula: C9H6ClNO, the main research area is dinitrile arylboronic acid palladium carbopalladation addition catalyst; ketonitrile preparation.

A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using com. available substrates. The method is expected to show further utility in future synthetic procedures.

Journal of Organic Chemistry published new progress about Addition reaction. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts