Yadav, Maruti B.; Vagh, Sandip S.; Jeong, Yeon Tae published the artcile< Divergent Annulation of Spiro[indoline-pyran] and Fused (Epoxyetheno)indeno-Furan from 1,2-Diketone and 1-Cyanoketone>, Synthetic Route of 21667-62-9 , the main research area is isatin benzoylacetonitrile base catalyst regioselective chemoselective Paal Knorr reaction; benzoylphenyl oxospiroindolinepyran carbonitrile preparation; acenaphthylenedione benzoylacetonitrile base catalyst regioselective chemoselective Paal Knorr reaction; epoxyethenoindeno furancarbonitrile preparation.
A simple and efficient method for the construction of spiro[indoline-pyran] and fused (epoxyetheno)indeno[1,2-b]furan compounds from 1-cyanoketones and 1,2-diketone was developed. The synthesis proceeded via the Knoevenagel and Michael adduct through intramol./Paal-Knorr cyclization under similar reaction condition. The less commonly used 1-cyanoketones and active carbonyl compounds served as the indole containing pyran and bicyclic furan source for the preparation of a new series of heterocyclic compounds This heterocyclic structure allows one and more than one tetra-substituted carbon center and sequential hexa- and penta-cyclic core under very mild conditions and showed excellent chemo and regioselectivity. In addition, the synthesis of spiro[indoline-pyran] and (epoxyetheno)indeno[1,2-b]furan was demonstrated in a gram scale.
European Journal of Organic Chemistry published new progress about Chemoselectivity. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Synthetic Route of 21667-62-9 .
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts