Category: 21667-62-9

Zhou, Chao; Diao, Pinhui; Li, Xiaoji; Ge, Yanqin; Guo, Cheng published the artcile< Facile photochemical synthesis of α-ketoamides and quinoxalines from amines and benzoylacetonitrile under mild conditions>, COA of Formula: C9H6ClNO, the main research area is acyl acetonitrile amine photochem oxidative coupling reaction; ketoamide preparation; phenylenediamine acyl acetonitrile photochem cyclocondensation reaction; arylquinoxaline carbonitrile preparation.

A selective protocol for the synthesis of either α-ketoamides or quinoxaline derivatives under the same reaction conditions was achieved simply by varying substitution number of amino-groups. The method features metal-free, room temperature and broad substrate scope as well as no extra oxidant. This process applied to various substituent groups and provided products in moderate to good yield. Finally, a rational mechanism was proposed.

Chinese Chemical Letters published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lai, Nang Duy; Nguyen, Thu Trang; Nguyen, Nhu Ngan Ha; Retailleau, Pascal; Mac, Dinh Hung; Nguyen, Thanh Binh published the artcile< Direct access to 2-aryl-3-cyanothiophenes by a base-catalyzed one-pot two-step three-component reaction of chalcones with benzoylacetonitriles and elemental sulfur>, Related Products of 21667-62-9, the main research area is chalcone benzoylacetonitrile diazabicyclooctane catalyst Michael addition sulfuration cyclization; diaryl cyanothiophene preparation; benzoylacetate chalcone diazabicyclooctane catalyst Michael addition sulfuration cyclization; diarylthiophene carboxylate preparation.

Herein, unexpected results on the formation of 3-cyanothiophene derivatives as the major products via a three-component reaction of chalcones, benzoylacetonitriles and elemental sulfur along with the minor products 2-aminothiophenes was reported. The ratios between these two thiophene products is 4 : 3 and could be varied by simply changing the promoting base as well as its stoichiometric ratio. The method was successfully extended to benzoylacetate in place of benzoylacetonitrile to provide thiophene-3-carboxylates.

Organic Chemistry Frontiers published new progress about Aromatic esters Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Related Products of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abou Elmaaty, Tarek; Elsisi, Hanan; Negm, Ilham published the artcile< Dyeing Characteristics of Polypropylene Fabric Dyed with Special Disperse Dyes Using Supercritical Carbon Dioxide>, Reference of 21667-62-9 , the main research area is polypropylene fabric dyeing disperse dye supercritical carbon dioxide.

Using disperse dyes of different colors and hues to produce a variety of shades is necessary for the industrialization of supercritical fluid dyeing of polypropylene. Eight derivatives of 3-(3-chlorophenyl)-1-phenyl-4-(diazenyl derivatives)-1H-pyrazol-5-amine dye were synthesized explicitly for use in supercritical carbon dioxide medium. Polypropylene dyeing was studied in supercritical carbon dioxide under varying conditions: Dyeing temperatures ranged from 100°C to 120°C, dying times ranged from 1 h to 2 h, concentrations ranged from 2% owf (on the weight of fabric) to 4%, and pressures ranged from 15 to 25 MPa. Significant improvement of the colorfastness to washing and rubbing was observed Raman spectroscopy was performed and showed conclusively that the dye was absorbed within all layers of polypropylene. This study achieved the elimination of water and its costly processing in the dyeing of synthetic fabrics.

Fibers and Polymers published new progress about Colorfastness. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Reference of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gonzalez-Fernandez, Rebeca; Crochet, Pascale; Cadierno, Victorio published the artcile< Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations>, Formula: C9H6ClNO, the main research area is ketonitrile preparation ruthenium catalyst tandem hydration transfer hydrogenation; hydroxyamide preparation.

A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides was reported. The process, that proceeded in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate involved the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles featuring diverse substitution patterns, the scope and limitations of the processed was established.

Journal of Organometallic Chemistry published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Suzuki, Itaru; Ogura, Kazuki; Shimazu, Jun-ya; Shibata, Ikuya published the artcile< Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes>, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is oxaspirooctene preparation diastereoselective chemoselective; methylenecyclopropane acyl cyanoalkene cyclization magnesium halide catalyst.

MgX2-catalyzed annulation of 1,1-di-Et 2-methylidenecyclopropane-1,1-dicarboxylate with acyl cyanoalkenes RC(O)C(CN)=CHAr (R = Me, Ph, 3-chlorophenyl, etc.; Ar = 4-fluorophenyl, 1-naphthyl, 2-furyl, etc.) was accomplished to give oxaspiro[2.5]octenes I (E = C(O)OEt) and II in excellent yields. The reaction proceeded through a rare intramol. oxa-Michael addition of Mg enolate. The oxaspiro ring was transformed into di-Et 2-((5-cyano-4,6-diphenyl-4H-pyran-2-yl)methyl)malonate at a higher temperature in the presence of MgX2.

European Journal of Organic Chemistry published new progress about Chemoselectivity. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gharui, Chandan; Parida, Chandrakanta; Pan, Subhas Chandra published the artcile< Organocatalytic Asymmetric Addition of Aromatic α-Cyanoketones to o-Quinone Methides: Synthesis of 3,4-Dihydrocoumarins and Tetra-Substituted Chromans>, Computed Properties of 21667-62-9 , the main research area is acetylnitrile phenylsulfonylmethyl phenol organocatalyst enantioselective cycloaddition reaction; phenyldihydrocoumarin phenyl cyanochroman preparation.

The first organocatalytic asym. addition of aromatic α-cyanoketones to in situ- generated o-quinone methides was developed. The products 3,4-dihydrocoumarin and tetra-substituted chroman were obtained via bifunctional squaramide catalyzed conjugate addition reaction to in situ- generated o-quinone methides followed by treatment with 0.7 N HCl. With 10 mol % of the catalyst, the desired products were obtained in high enantio- and diastereoselectivities.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Junlong; Chen, Heng; Yang, Jie; Yu, Zutao; Huang, Pan; Yang, Haofeng; Zheng, Bifeng; Liu, Rangru; Li, Qianbin; Hu, Gaoyun; Chen, Zhuo published the artcile< Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors>, Computed Properties of 21667-62-9 , the main research area is neoplasm antitumor BRD4 BD1; BD1 inhibitor; BRD4; Cancer; Computer-aided drug design; Fibrosis; Structure-activity relationship.

Bromodomain-containing protein 4 (BRD4), consisting of two tandem bromodomains (BD1 and BD2), is key epigenetic regulator in fibrosis and cancer, which has been reported that BD1 and BD2 have distinct roles in post-translational modification. But there are few selective inhibitors toward those two domains. Herein, this study designed and synthesized a series of novel selective BRD4-BD1 inhibitors, using computer-aided drug design (CADD) approach focused on exploring the difference of the binding pockets of BD1 and BD2, and finding the His437 a crucial way to achieve BRD4-BD1 selectivity. Our results revealed that the compound 3u(I) is a potent selective BRD4-BD1 inhibitor with IC50 values of 0.56 μM for BD1 but >100 μM for BD2. I exhibited a broad spectrum of anti-proliferative activity against several human cancer and fibroblastic cell lines, which might be related to its capability of reducing the expression of c-Myc and collagen I. Furthermore, I could induce apoptosis in A375 cells. To the contrary, the selective BD2 inhibitor, RVX-208, did not indicate any of these activities. Our findings highlight that the function of BRD4-BD1 might be predominant in fibrosis and cancer. And it is rational to further develop novel selective BRD4-BD1 inhibitors.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gore, Babasaheb Sopan; Lin, Jun-Hao; Wang, Jeh-Jeng published the artcile< Unraveling innate substrate-controlled arylation and bicyclization of 1,5-enynes with α,β conjugates: synthesis of substituted benzo[a]fluorenes>, Category: nitriles-buliding-blocks, the main research area is enyne unsaturated ketone arylation arene cyclization Friedel Crafts; benzofluorene aryl regioselective preparation green chem.

A strategy for the aromatic C-H functionalization of electron-rich arenes, such as anisole, phenol, veratrol, toluene or naphthalene, with 1,5-enynes anchored by conjugates, e.g., I (X = CN, EtO2C, Ts, PhCO; R1 = n-Bu, Ph, 3-FC6H4, etc.; R2 = H, 4-Me, 5-F, 4-MeO, etc.; R3 = H, 4-Cl, 3-F, 3-Br, etc.) catalyzed by a Bronsted acid under metal- and solvent-free conditions has been developed. A diverse range of benzo[a]fluorenes, e.g., II [R4 = 4-MeOC6H4, 4-HOC6H4, 3,4-(MeO)2C6H3] [from I (X = CN)] or III (R4 = 4-MeOC6H4, 4-MeC6H4, 1-naphthyl), was obtained in moderate to good yields by using this protocol. This process includes intermol. nucleophilic arene insertion or 6-exo-dig cyclization (depending on the nature of the substrates) followed by a Friedel-Crafts-type reaction and 1,5-H transfer or intermol. nucleophilic arene insertion, resp. In addition, reactions with heterocyclic compounds such as (E)-2-benzoyl-3-(2-(phenylethynyl)pyridin-3-yl)acrylonitrile proceeded smoothly and afforded 11-phenyl-11H-indeno[1,2-h]quinoline-6-carbonitrile. Moreover, solvent recycling experiments were successfully carried out to illustrate green pathways. These reactions feature a readily accessible starting materials, transition metal-free approaches, simple one-pot operations, gram-scale syntheses and wide functional group tolerance.

Green Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

He, Zhonglei; Charleton, Clara; Devine, Robert W.; Kelada, Mark; Walsh, John M. D.; Conway, Gillian E.; Gunes, Sebnem; Mondala, Julie Rose Mae; Tian, Furong; Tiwari, Brijesh; Kinsella, Gemma K.; Malone, Renee; O’Shea, Denis; Devereux, Michael; Wang, Wenxin; Cullen, Patrick J.; Stephens, John C.; Curtin, James F. published the artcile< Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma>, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is pyrazolopyrimidinone cold atm plasma reactive oxygen species cytotoxicity; Cold atmospheric plasma; Glioblastoma; Pro-drug; Programmable cytotoxicity; Pyrazolopyrimidinone; ROS.

Pyrazolopyrimidinones are fused nitrogen-containing heterocyclic systems, which act as a core scaffold in many pharmaceutically relevant compounds Pyrazolopyrimidinones have been demonstrated to be efficient in treating several diseases, including cystic fibrosis, obesity, viral infection and cancer. In this study using glioblastoma U-251MG cell line, we tested the cytotoxic effects of 15 pyrazolopyrimidinones, synthesized via a two-step process, in combination with cold atm. plasma (CAP). CAP is an adjustable source of reactive oxygen and nitrogen species as well as other unique chem. and phys. effects which has been successfully tested as an innovative cancer therapy in clin. trials. Significantly variable cytotoxicity was observed with IC50 values ranging from around 11μM to negligible toxicity among tested compounds Interestingly, two pyrazolopyrimidinones were identified that act in a prodrug fashion and display around 5-15 times enhanced reactive-species dependent cytotoxicity when combined with cold atm. plasma. Activation was evident for direct CAP treatment on U-251MG cells loaded with the pyrazolopyrimidinone and indirect CAP treatment of the pyrazolopyrimidinone in media before adding to cells. Our results demonstrated the potential of CAP combined with pyrazolopyrimidinones as a programmable cytotoxic therapy and provide screened scaffolds that can be used for further development of pyrazolopyrimidinone prodrug derivatives

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gharui, Chandan; Parida, Chandrakanta; Pan, Subhas Chandra published the artcile< Organocatalytic Asymmetric Addition of Aromatic α-Cyanoketones to o-Quinone Methides: Synthesis of 3,4-Dihydrocoumarins and Tetra-Substituted Chromans>, HPLC of Formula: 21667-62-9, the main research area is acetylnitrile phenylsulfonylmethyl phenol organocatalyst enantioselective cycloaddition reaction; phenyldihydrocoumarin phenyl cyanochroman preparation.

The first organocatalytic asym. addition of aromatic α-cyanoketones to in situ- generated o-quinone methides was developed. The products 3,4-dihydrocoumarin and tetra-substituted chroman were obtained via bifunctional squaramide catalyzed conjugate addition reaction to in situ- generated o-quinone methides followed by treatment with 0.7 N HCl. With 10 mol % of the catalyst, the desired products were obtained in high enantio- and diastereoselectivities.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, HPLC of Formula: 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts