Category: 214623-57-1

Electric Literature of 214623-57-1,Some common heterocyclic compound, 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a 2-Methoxyl-5-N-[[4-morpholino]carbonyl]amino benzonitrile To a stirred mixture of 2-methoxyl-5-aminobenzonitrile (2 g, 12.34 mmol), and pyridine (1.28 g, 16.2 mmol) in dried CH2Cl2 (20 mL) was added 4-morpholinecarbonyl chloride (2.42 g, 16.2 mmol). After stirring at RT for 24 h, the mixture was diluted with CH2Cl2 and washed with H2O, brine, dried over MgSO4, concentrated to give an orange solid (3.04 g, 86%) 1H NMR: (400MHz, DMSO-d6): d 3.23 (t, J=4.9 Hz, 4H), 3.47 (t, J=4.9 Hz, 4H), 3.9 (s, 3H), 6.89 (d, J=9 Hz, 1H), 7.3 (d, J=9 Hz, 1H), 8.01 (s, 1H).

The synthetic route of 214623-57-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SmithKline Beecham Corporation; US6294531; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H8N2O

Example 9: 2-Methoxy-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]- benzonitrileA suspension of 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine (180mg, 0.619mmol), 5-amino-2-methoxybenzonitrile(91.7mg, 0.557mmol), in’5′(dibenzylidene-acetone)palladium(0) (28.3mg, 0.030mmol), 4,5- bi5′(diphenylphosphino)-9,9-dimethyl-xanthene (35.8mg, 0.061mmol) and cesium carbonate (403mg, 1.238mmol) in degassed 1,4-dioxane (4mL) was heated at 80C for 2 days. The suspension was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgS04) and the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica (ethyl acetate: hexane, 1:1) to afford 2-methoxy-5-[5-(3-morpholin-4-ylphenoxy)- pyrimidin-2-ylamino]-benzonitrile as solid (113mg, 46%).Mass: (ES+) 404 (M+H)+ HPLC: 99%NMR: deltaEta ( 6-DMSO) 3.08 (4H, m), 3.69 (4H, m), 3.88 (3H, s), 6.37 (1H, dd), 6.59 (1H, br s), 6.68 (1H, dd), 7.17 (1H, d), 7.20 (1H, t), 7.86 (1H, dd), 8.12 (1H, d), 8.38 (2H, s) and 9.80 (1H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 214623-57-1.

Application of 214623-57-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Sodium nitrite (l.llg, 16.17 mmol) in water (5 ml) was added with stirring over 15 min to a cold (0 C) solution of A (2.18 g,14.7 mmol) in concentrated hydrochloric acid (7 ml) and ice (10 g). The mixture was stirred at 0 C for a further 20 min. and the cold solution was added over 30 min to a stirred solution (room temperature) of potassium iodide (12.2 g, 73 mmol) in water (15 ml). The mixture was left standing at room temperature overnight and extracted with dichlormethane (2×50 ml). The combined organic extracts were washed successively with 10% NaOH, water, and dried (Na2S04). Evaporation of the solvent and silica gel column chromatography of the residue (Hexanes/EtOAc) gave iodide B (3.46 g, 80%).

The chemical industry reduces the impact on the environment during synthesis 5-Amino-2-methoxybenzonitrile. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Amino-2-methoxybenzonitrile

General procedure: A solution of 5-amino-2-alkoxybenzonitrile (20mmol), glacial acetic acid (50mL) and water (20mL) was added to the reaction flask at -10C under stirring, water-soluble sodium azide (30 mmol) was slowly added dropwise to the reaction mixture for 30 min, and the addition was completed,the reaction temperature is maintained steady 3h, extracted with dichloromethane, the organic layers combined, washed with brine, dried over anhydrous sodium sulfate , filtered, and concentrated to dryness under reduced pressure the crude product purified by column chromatography (ethyl acetate: petroleum ether = 1: 5) to give pure product.

The synthetic route of 5-Amino-2-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHINA MEDICAL UNIVERSITY; MENG, FANHAO; ZHANG, TINGJIAN; WU, QINGXIA; WANG, LIN; SUN, QI; LIANG, JINGWEI; HE, XIN; (22 pag.)CN105294584; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 214623-57-1,Some common heterocyclic compound, 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a 2-Methoxyl-5-N-[[4-morpholino]carbonyl]amino benzonitrile To a stirred mixture of 2-methoxyl-5-aminobenzonitrile (2 g, 12.34 mmol), and pyridine (1.28 g, 16.2 mmol) in dried CH2Cl2 (20 mL) was added 4-morpholinecarbonyl chloride (2.42 g, 16.2 mmol). After stirring at RT for 24 h, the mixture was diluted with CH2Cl2 and washed with H2O, brine, dried over MgSO4, concentrated to give an orange solid (3.04 g, 86%) 1H NMR: (400MHz, DMSO-d6): d 3.23 (t, J=4.9 Hz, 4H), 3.47 (t, J=4.9 Hz, 4H), 3.9 (s, 3H), 6.89 (d, J=9 Hz, 1H), 7.3 (d, J=9 Hz, 1H), 8.01 (s, 1H).

The synthetic route of 214623-57-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SmithKline Beecham Corporation; US6294531; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts