Category: 21423-84-7

Xie, Hao; Li, Guozheng; Zhang, Feng; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Efficient synthesis of 1,2-benzisothiazoles from o-haloarylamidines and elemental sulfur via N-S/C-S bond formation under transition-metal-free conditions>, Formula: C8H6ClN, the main research area is haloaryl phenylamidine preparation sulfur heterocyclization; benzisothiazole preparation.

An efficient method for the synthesis of 1,2-benzisothiazoles from amidines and elemental sulfur via N-S/C-S bond formation under transition-metal-free conditions was described. This reaction was performed smoothly under simple conditions to give the corresponding products in good to high yields with good functional group tolerance.

Green Chemistry published new progress about Amidines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Formula: C8H6ClN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group [Erratum to document cited in CA158:330848]>, HPLC of Formula: 21423-84-7, the main research area is erratum halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst erratum.

The authors provide clarification that there is competition during the halogenation of 4-methoxybenzonitrile and revise the corresponding results.

Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, HPLC of Formula: 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kozlov, Maxim V.; Kleymenova, Alla A.; Romanova, Lyudmila I.; Konduktorov, Konstantin A.; Smirnova, Olga A.; Prasolov, Vladimir S.; Kochetkov, Sergey N. published the artcile< Benzohydroxamic acids as potent and selective anti-HCV agents>, SDS of cas: 21423-84-7, the main research area is benzohydroxamic Hepatitis C Poliomyelitis structure activity preparation; Benzohydroxamic acids; Hepatitis C virus; Metal-depending enzymes; Poliomyelitis virus.

A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, SDS of cas: 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mills, L. Reginald; Edjoc, Racquel K.; Rousseaux, Sophie A. L. published the artcile< Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles>, Application In Synthesis of 21423-84-7, the main research area is quaternary aryl nitrile synthesis; benzonitrile ligand nickel catalyzed cross coupling tertiary nucleophile; safety cyanide.

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles. Safety: cyanide handling.

Journal of the American Chemical Society published new progress about Aromatic nitriles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Application In Synthesis of 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiang, Min; Li, Haifang; Yang, Haijun; Fu, Hua published the artcile< Room-Temperature Arylation of Thiols: Breakthrough with Aryl Chlorides>, Application of C8H6ClN, the main research area is aryl sulfide preparation; thiol aryl halide visible light photoredox arylation; C−S coupling; arylation; photocatalysis; synthetic methods; thiols.

The formation of aryl C-S bonds is an important chem. transformation because aryl sulfides are valuable building blocks for the synthesis of biol. and pharmaceutically active mols. and organic materials. Aryl sulfides have traditionally been synthesized through the transition-metal-catalyzed cross-coupling of aryl halides with thiols. However, the aryl halides used are usually bromides and iodides; readily available, low-cost aryl chlorides often not reactive enough. Furthermore, the deactivation of transition-metal catalysts by thiols has forced chemists to use high catalyst loadings, specially designed ligands, high temperatures, and/or strong bases, thus leading to high costs and the incompatibility of some functional groups. Herein, we describe a simple and efficient visible-light photoredox arylation of thiols with aryl halides at room temperature More importantly, various aryl chlorides are also effective arylation reagents under the present conditions.

Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Application of C8H6ClN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sakauchi, Nobuki; Kohara, Yasuhisa; Sato, Ayumu; Suzaki, Tomohiko; Imai, Yumi; Okabe, Yuichi; Imai, Shigemitsu; Saikawa, Reiko; Nagabukuro, Hiroshi; Kuno, Haruhiko; Fujita, Hisashi; Kamo, Izumi; Yoshida, Masato published the artcile< Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities>, Product Details of C8H6ClN, the main research area is adrenoceptor antagonist incontinence hERG; crystal structure adrenoceptor antagonist incontinence.

A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through screening of an inhouse compound library. From initial structure-activity relationship studies, we found lead compound 9m with hERG K+ channel liability. To develop analogs with reduced hERG K+ channel inhibition, a combination of site-directed mutagenesis and docking studies was employed. Further optimization led to the discovery of I and II, which showed antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, as well as ameliorated cystitis-induced urinary frequency in rats. Ultimately, 9u was selected as a clin. candidate. This is the first study to show the utility of iminopyridine derivatives as selective α1D-AR antagonists and evaluate their effects in vivo.

Journal of Medicinal Chemistry published new progress about Androgen receptor antagonists. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Product Details of C8H6ClN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wurz, Gerald; Hofer, Otmar; Greger, Harald published the artcile< Structure and synthesis of phenaglydon, a new quinolone derived phenanthridine alkaloid from Glycosmis cyanocarpa>, Safety of 2-Chloro-4-methylbenzonitrile, the main research area is phenaglydon phenanthridine alkaloid Glycosmis structure; schinifoline Glycosmis.

A novel quinolone derived alkaloid of the phenanthridine type, phenaglydon (I), has been isolated from the lipophilic leaf extract of Glycosmis cyanocarpa (Rutaceae) together with schinifoline (II), a prenylated 2-quinolinone characterized by a diene grouping in the side chain. Both structures have been elucidated on spectroscopic evidence. In the case of phenaglydon the proposed structure has addnl. been confirmed by synthesis. The co-occurrence of these alkaloids suggests close biogenetic connections between the two compounds

Natural Product Letters published new progress about Glycosmis cyanocarpa. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Safety of 2-Chloro-4-methylbenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bochis, Richard J.; Chabala, John C.; Harris, Ellwood; Peterson, Louis H.; Barash, Louis; Beattie, Thomas; Brown, Jeannette E.; Graham, Donald W.; Waksmunski, Frank S. published the artcile< Benzylated 1,2,3-triazoles as anticoccidiostats>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is triazole benzylated preparation anticoccidiostat; carbamoylaminotriazole preparation anticoccidiostat; structure activity carbamoylaminotriazole anticoccidiostat; aminobenzylcarbamoyltriazole preparation anticoccidiostat; benzyltriazole aminocarbamoyl preparation anticoccidiostat.

Substituted aminocarbamoyltriazoles I (R = Cl, H, COC6H4Cl-4; R1 = COC6H4R3, COPh, H, Cl, R3 = 4-Cl, 4-F, 4-cyano, 4-CO2Me, 4-CCl:CCl2, 4-Br, 4-iodo; R1 = COC6H3Cl2-3,4, COC6H3Cl2-2,6, etc.; R2 = H, Cl, F, Br) were prepared and evaluated in vivo for anticoccidial activity. Thus, N-alkylation of 5-amino-4-carbamoyl-1,2,3-triazole with benzene derivatives II (R4 = Br) gave I. Cyclization of II (R4 = N3) with 2-cyanoacetamide also gave I. I (R = R2 = Cl, R1 = COC6H4Cl-4) is a highly effective coccidiostat. An increase in activity was observed when the CO of the benzophenone moiety is flanked by halogens as in I (R = R2 = Cl, R1 = COC6H4Cl-4; R = R2 = Cl, R1 = COPh).

Journal of Medicinal Chemistry published new progress about Coccidiostats. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xie, Hao; Xing, Qiaoyan; Shan, Zhifei; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Nickel-Catalyzed Annulation of o-Haloarylamidines with Aryl Acetylenes: Synthesis of Isoquinolone and 1-Aminoisoquinoline Derivatives>, SDS of cas: 21423-84-7, the main research area is isoquinolone aminoisoquinoline benzoimidazoisoquinoline preparation regioselective; haloarylamidine aryl acetylene annulation nickel catalyst.

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives I (R1 = H, 8-Me, 6-F etc.; R2 = H, 4-Me, 3-Cl, etc.; R3 = H, Me, n-Bu, Ph, COOEt; R4 = Ph, 4-MeC6H4, 3-pyridyl, etc.) via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines II (R1 = R2 = H; R3 = H, C6H5; R4 = C6H5, 4-FC6H4, 4-MeOC6H4, etc.) were formed as the dominated products when dry DMSO was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occurred to provide various 1-aminoisoquinoline products.

Advanced Synthesis & Catalysis published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, SDS of cas: 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst.

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature Using cyano as the directing group, the halogenation reaction gave good to excellent yields. E.g., in presence of Pd(OAc)2 and p-toluenesulfonic acid, reaction of PhCN and NIS gave 84% 2-IC6H4CN. The method is compatible for arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available at least the gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts