Category: 2042-37-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2042-37-7 as follows. HPLC of Formula: C7H4BrN

General procedure: In 50 mL round bottom flask, aryl halide (1.0 mmol), pyrazole (1.2 mmol), ligand (0.04 mmol), Cu2O (0.10 mmol), cesium carbonate (2.0 mmol), and dry solvent (20 mL) were placed under nitrogen atmosphere. The reaction mixture was heated in oil bath up to specified temperature under constant stirring for 20 h and then allowed to cool to room temperature. The reaction mixture was filtered through a plug of Celite in a fritted filter funnel and washed with ethyl acetate. If DMSO is used as solvent, it is extracted by washing the filtrate with 25 mL water for three times. The organic phase was dried over anhydrous MgSO4 and was removed under reduced pressure to provide the crude product which was purified by column chromatography on silica gel, using hexane and ethyl acetate in 3:1 ratio, respectively, as an eluent.

According to the analysis of related databases, 2042-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Damkaci, Fehmi; Alawaed, Abdulkhaliq; Vik, Erik; Tetrahedron Letters; vol. 57; 20; (2016); p. 2197 – 2200;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2042-37-7, name is 2-Bromobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H4BrN

General procedure: An aryl halide (0.5 mmol), arylboronic acid (0.75 mmol),(i-Pr)2NH (1.0 mmol), Pd/C (1.5 mol%, 16 mg), and water (1.0mL) were allowed to react at 100 C. After a certain period, the reaction mixture was added to brine (10 mL) and extracted with ethyl acetate (3 × 10 mL). The solvent was concentrated under vacuum, and the product was isolated by short chromatography on a silica-gel (200-300 mesh) column.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rao, Xiaofeng; Liu, Chun; Zhang, Yixia; Gao, Zhanming; Jin, Zilin; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 35; 3; (2014); p. 357 – 361;,
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2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H4BrN

Example 2 2M Sodium carbonate solution (200 ml) was added to a stirred mixture of 4-methylphenylboronic acid (30 g), 2-bromobenzonitrile (36.4 g), palladium (II) chloride (0.4 g), methanol (200 ml) and toluene (200 ml) at 5C. The temperature rose to approximately 20C and a solid precipitated. The reaction mixture was then heated at reflux for 2 hours. The reaction mixture was allowed to cool and water (100 ml) was added, followed by diatomaceous earth (5 g). The mixture was stirred for 15 minutes, then filtered through diatomaceous earth. The organic phase of the filtrate was separated and washed with 2M sodium carbonate solution and then water. The organic phase was then filtered and the filtrate evaporated. The resultant solid was recrystallized from petroleum ether (b.p. 110-120C) to give 4–methylbiphenyl-2-carbonitrile (in 80% yield) identical to that obtained in Example 1.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZENECA LIMITED; EP470795; (1992); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2042-37-7, SDS of cas: 2042-37-7

General procedure: In air, potassium phosphate (3mmol, 0.636g), catalyst 1 (0.08mol%, 0.0009g) and arylboronic acid (2mmol) were weighed into a 50mL glass vial that was sealed with a septum and purged with N2 (3¡Á). Dioxane (1mL) was then injected via syringe followed by the aryl bromide (1mmol) (if liquid). If the aryl bromide was a solid, it was introduced into the vial prior to purging with N2. At this time, the reaction stirred for 24h at 100C. The reaction mixture was concentrated in vacuo and directly purified via silica gel flash chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich; Tetrahedron; vol. 70; 17; (2014); p. 2829 – 2837;,
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Reference of 2042-37-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2042-37-7, name is 2-Bromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 213 mg (1 mmol) Int1.2 in THF (2.5 mL) was added 364 mg (2 mmol, 2 eq) 2-Brombenzonitril, 183 mg (0.2 mmol, 0.2 eq) Pd2(dba)3, 374 mg (0.6 mmol, 0.6 eq) rac-BINAP and 240 mg (2.5 mmol, 2.5 eq) NaOtBu at room temperature in a microwave reactor. The solution was heated at 150 C for 50 min under microwave irradiation. After cooling, the solution was filtered and evaporated. Subsequent purification by by preparative reverse phase HPLC gave 186 mg (59 %) of the title compound. 1H-NMR (300 MHz, d6-DMSO): delta = 9.56 (1H, s), 9.16 (1H, s), 7.91 (1H, d), 7.72 (1 H, d), 7.70 (1 H, d), 7.62 (1 H, dd) 7.54 (1 H, d), 7.15 (1 H, dd) ppm. UPLC-MS: RT = 1.15 min; m/z (ES+) 315.2 [MH+]; required MW = 314.2.

The chemical industry reduces the impact on the environment during synthesis 2-Bromobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer Schering Pharma AG; EP2343297; (2011); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2042-37-7 as follows. Recommanded Product: 2-Bromobenzonitrile

Preparation 6 A solution of 1.5M butyllithium in hexane (25 ml) in tetrahydrofuran (25 ml) was cooled at -78C by using dry ice-acetone bath under nitrogen atmosphere and a solution of 4-bromotoluene (6.40 g) in tetrahydrofuran (25 ml) was added dropwise to the solution. After being stirred at -78C for 1 hour, a solution of freshly fused zinc chloride (5.15 g) in tetrahydrofuran (25 ml) was added in a slow stream via cannula and the resulting mixture was allowed to warm to room temperature. The mixture was stirred at room temperature for 1 hour and the resulting solution was added to a solution of 2-bromobenzonitrile (4.55 g) and tetrakis(triphenylphosphine)palladium(0) (400 mg) in tetrahydrofuran (25 ml) at room temperature. The solution was stirred at room temperature overnight. The solution was diluted with ethyl acetate (300 ml) and washed successively with 1N-hydrochloric acid, water, and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography with a mixture of ethyl acetate and n-hexane (1:20) as eluent to give 2-cyano-4–methylbiphenyl (4.43 g) as white powders. mp: 44-47C NMR (CDCl3, delta): 2.42 (3H, s), 7.25-7.35 (2H, m), 7.35-7.5 (4H, m), 7.62 (1H, dt, J=1, 7.5Hz), 7.85 (1H, dd, J=1, 7.5Hz)

According to the analysis of related databases, 2042-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP426021; (1991); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2042-37-7, category: nitriles-buliding-blocks

General procedure: In an undivided cellequipped with a Zn sacrificial anode (1.5 x 1.0 cm2) and a Pt cathode (1.5 x 1.0 cm2) was placed a DMF(3 mL) solution of 4-bromopropiophenone (4a, 0.053 g, 0.25 mmol), 1 (0.14 g, 7.6 x 10-2 mmol),[Bu4N+][Tf2N-] (0.16 g, 0.30 mmol), and a catalytic amount of PdCl2(PPh3)2 (0.0086 g, 1.2 x 10-2 mmol).The solution was electrolyzed under constant current conditions (10 mA) at 60 C until 2 F/mol-4a ofelectricity was passed. The reaction mixture was poured into 5% aq. HCl (12 mL). The mixture wasextracted with AcOEt (10 mL x 3). The combined organic layer was washed successively with waterand brine, dried (Na2SO4), and concentrated under reduced pressure. The residue was purified bycolumn chromatography (SiO2, toluene/AcOEt = 10/1) to afford 4,4?-dipropanoylbiphenyl (5a, 0.030 g,0.11 mmol, 89%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kuroboshi, Manabu; Kojima, Atsuki; Tanaka, Hideo; Heterocycles; vol. 94; 11; (2017); p. 2132 – 2140;,
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2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2042-37-7

General procedure: Phenylboronic acid (1.5mmol), aryl chloride (1.0mmol), K2CO3 (2.0mmol), PEPPSI-type palladium-NHC catalyst (0.01mmol, 1mol%) (2a-f) and mixture of isopropanol/water (1:3; v/v) (4mL) were added to a small round bottom flask in air. The mixture was stirred at 50C for 2h. At the end of the reaction, the cooled solution to room temperature was extracted with a mixture of EtOAc/n-hexane (1:5, v/v). The organic phase was separated and dried over anhydrous MgSO4, the solution passed through the micro silica gel column was concentrated. Product characterizations were performed by GC. The reaction yields were determined by GC based on aryl chloride.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kalo?lu, Nazan; Oezdemir, ?smail; Tetrahedron; vol. 75; 15; (2019); p. 2306 – 2313;,
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Synthetic Route of 2042-37-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2042-37-7 as follows.

General procedure: The aryl halide (5.0 mmol), arylboronic acid (7.5 mmol), base (10.0 mmol), the calculated amount of thiourea, Pd and H2O (5 mL) were added to a flask containing a magnetic stir bar under air. The flask was sealed with a rubber septum and the contents were stirred at the specified temperature for the appropriate period of time. Upon completion, the reaction mixture was extracted using Et2O (3 10 mL). The solvent was removed on a rotary evaporator and the residue was purified by flash chromatography on silica gel to afford the desired product. The coupling products were characterized by 1H NMR and 13C NMR spectroscopy (see the Supporting Information). The identities of the products were confirmed by comparison with literature spectroscopic data.

According to the analysis of related databases, 2042-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Wei; Lu, Xiao-Yan; Xu, Bei-Hua; Yu, Wei-Guo; Zhou, Zi-Niu; Hu, Ying; Synthesis; vol. 50; 7; (2018); p. 1499 – 1510;,
Nitrile – Wikipedia,
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2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2042-37-7

Intermediate Example Int3.1(6-Bromo-[1 ,2,4]triazolo[1 ,5-a]pyridin-2-yl)-o-cyanophenyl-amineTo a stirred solution of 213 mg (1 mmol) Int1.2 in THF (2.5 mL) was added 364 mg (2 mmol, 2 eq) 2-Brombenzonitril, 183 mg (0.2 mmol, 0.2 eq) Pd2(dba)3, 374 mg (0.6 mmol, 0.6 eq) rac-BINAP and 240 mg (2.5 mmol, 2.5 eq) NaOtBu at room temperature in a microwave reactor. The solution was heated at 150 C for 50 min under microwave irradiation. After cooling, the solution was filtered and evaporated. Subsequent purification by by preparative reverse phase HPLC gave 186 mg (59 %) of the title compound.1H-NMR (300 MHz, d6-DMSO): delta = 9.56 (1H, s), 9.16 (1 H, s), 7.91 (1 H, d), 7.72 (1 H, d), 7.70 (1 H, d), 7.62 (1H, dd) 7.54 (1 H, d), 7.15 (1H, dd) ppm. UPLC-MS: RT = 1.15 min; m/z (ES+) 315.2 [MH+]; required MW = 314.2.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; KOPPITZ, Marcus; KOSEMUND, Dirk; SCHIROK, Hartmut; BADER, Benjamin; LIENAU, Philip; WENGNER, Antje; BRIEM, Hans; HOLTON, Simon; SIEMEISTER, Gerhard; PRECHTL, Stefan; BOeMER, Ulf; WO2011/63908; (2011); A1;,
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