Category: 2042-37-7

Mills, L. Reginald’s team published research in Journal of the American Chemical Society in 2021 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Electric Literature of C7H4BrN

Electric Literature of C7H4BrNIn 2021 ,《Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles》 appeared in Journal of the American Chemical Society. The author of the article were Mills, L. Reginald; Edjoc, Racquel K.; Rousseaux, Sophie A. L.. The article conveys some information:

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles. Safety: cyanide handling. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Electric Literature of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Electric Literature of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lou, Terry Shing-Bong’s team published research in Angewandte Chemie, International Edition in 2022 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Recommanded Product: 2-Bromobenzonitrile

Recommanded Product: 2-BromobenzonitrileIn 2022 ,《Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2》 was published in Angewandte Chemie, International Edition. The article was written by Lou, Terry Shing-Bong; Kawamata, Yu; Ewing, Tamara; Correa-Otero, Guillermo A.; Collins, Michael R.; Baran, Phil S.. The article contains the following contents:

The sulfonyl fluorides ArSO2F [Ar = 2-MeOC6H4, 4-FC6H4, 3,5-di-MeC6H3, etc.] were synthesized via electrochem. sulfinylation and fluorination of aryl iodides and bromides through aryl sulfinate intermediate using an inexpensive Ni-electrocatalytic protocol. The reaction exhibited a broad scope, used stock solution of simple SO2 as sulfur source, and could be scaled up in batch and recycle flow settings. The limitations of this reaction were clearly shown and put into context by benchmarking with state-of-the-art Pd-based methods. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ataie, Saeed’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Name: 2-Bromobenzonitrile

In 2022,Ataie, Saeed; Ovens, Jeffrey S.; Tom Baker, R. published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Solvent-free Zn (NSNO) complex-catalysed dihydroboration of nitriles》.Name: 2-Bromobenzonitrile The author mentioned the following in the article:

N-donors are the most commonly employed Lewis bases in ligand-assisted catalysis. A dimeric zinc complex (Zn-1) employing a tetradentate pyridine-thioether-anilido-aryloxide NSNO ligand (L) effects the quant. conversion of nitriles to the corresponding double hydroborated products at 1 mol% catalyst loading. Variable Time Normalization Anal. kinetic studies showed a first-order dependence with respect to the nitrile, pinacolborane and zinc and clear evidence for catalyst deactivation. A plausible ligand-assisted reaction pathway involves B-H bond activation by the aryloxide (vs. anilido) donor. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Da-Liang’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Related Products of 2042-37-7

In 2022,Zhu, Da-Liang; Jiang, Shan; Young, David James; Wu, Qi; Li, Hai-Yan; Li, Hong-Xi published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Visible-light-driven C(sp2)-H arylation of phenols with arylbromides enabled by electron donor-acceptor excitation》.Related Products of 2042-37-7 The author mentioned the following in the article:

A catalyst-free visible-light-driven C(sp2)-H arylation of unprotected phenols ROH (R = Ph, naphthalen-2-yl, 3,5-dibromophenyl, etc.) with arylbromides R1Br (R1 = 4-cyclopropanecarbonylbenzen-1-yl, 2-cyanobenzen-1-yl, 3-cyano-5-(trifluoromethyl)phenyl, etc.) to give 2-arylated phenols RR1 have been developed. This reaction proceeds through the excitation of an electron donor-acceptor complex between a phenolate and arylbromide, electron transfer, and debrominative C(sp2)-C(sp2) coupling. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Related Products of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Related Products of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hota, Pradip Kumar’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7

《NHC-catalyzed silylative dehydration of primary amides to nitriles at room temperature》 was written by Hota, Pradip Kumar; Maji, Subir; Ahmed, Jasimuddin; Rajendran, N. M.; Mandal, Swadhin K.. Product Details of 2042-37-7 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

In the presence of the abnormal imidazolylidene carbene I, primary amides underwent chemoselective dehydrogenative dehydration reactions with phenylsilane to yield nitriles; the method bypasses the energetically demanding 1,2-siloxane elimination step usually required for metal/silane catalyzed reactions. The mechanism of the was dehydrogenative dehydration studied using DFT calculations of the transition state structures and their free energies and enthalpies on the dehydration pathway; a silane adduct of I was characterized by NMR and evidence for the formation of H2 and of a disiloxane byproduct provided. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kasina, Krishna Chaitanya’s team published research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2021 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.HPLC of Formula: 2042-37-7

Kasina, Krishna Chaitanya; Rapeti, Siva Kumar; Sadhukhan, Arghya; Ranga, Mahesh; Pal, Arani; Birudaraju, Saritha; Tirukkovalluri, Siva rao published their research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2021. The article was titled 《Silver-assisted palladium-catalyzed one-pot synthesis of 3-(hetero)arylmethyl derivatives of imidazo[1,2-a]pyridines》.HPLC of Formula: 2042-37-7 The article contains the following contents:

3-(Hetero)arylmethyl derivatives of imidazo[1,2-a]pyridine were synthesized by a novel one-pot method consisting of the Sonogashira coupling of tert-Bu prop-2-yn-1-yl(pyridin-2-yl)carbamate with different substituted (hetero)aryl bromides and cyclization of the in-situ obtained intermediate substituted (hetero)aryl acetylene derivatives In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sep-21 News Brief introduction of 2042-37-7

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2042-37-7, name is 2-Bromobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromobenzonitrile

General procedure: An aryl halide (0.5 mmol), arylboronic acid (0.75 mmol),(i-Pr)2NH (1.0 mmol), Pd/C (1.5 mol%, 16 mg), and water (1.0mL) were allowed to react at 100 C. After a certain period, the reaction mixture was added to brine (10 mL) and extracted with ethyl acetate (3 × 10 mL). The solvent was concentrated under vacuum, and the product was isolated by short chromatography on a silica-gel (200-300 mesh) column.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rao, Xiaofeng; Liu, Chun; Zhang, Yixia; Gao, Zhanming; Jin, Zilin; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 35; 3; (2014); p. 357 – 361;,
Nitrile – Wikipedia,
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9/14/21 News Brief introduction of 2042-37-7

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

2042-37-7, name is 2-Bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Bromobenzonitrile

Example 2 2M Sodium carbonate solution (200 ml) was added to a stirred mixture of 4-methylphenylboronic acid (30 g), 2-bromobenzonitrile (36.4 g), palladium (II) chloride (0.4 g), methanol (200 ml) and toluene (200 ml) at 5C. The temperature rose to approximately 20C and a solid precipitated. The reaction mixture was then heated at reflux for 2 hours. The reaction mixture was allowed to cool and water (100 ml) was added, followed by diatomaceous earth (5 g). The mixture was stirred for 15 minutes, then filtered through diatomaceous earth. The organic phase of the filtrate was separated and washed with 2M sodium carbonate solution and then water. The organic phase was then filtered and the filtrate evaporated. The resultant solid was recrystallized from petroleum ether (b.p. 110-120C) to give 4–methylbiphenyl-2-carbonitrile (in 80% yield) identical to that obtained in Example 1.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZENECA LIMITED; EP470795; (1992); A1;,
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6-Sep-2021 News Share a compound : 2042-37-7

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2042-37-7, A common heterocyclic compound, 2042-37-7, name is 2-Bromobenzonitrile, molecular formula is C7H4BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: K3PO4 (5.62 mmol) in DMSO (4 mL), were added Cu(OAc)2 (0.28 mmol). The flask was evacuatedand backfilled with argon for three times. The resulting suspension was heated in a 80 C oil bathwith stirring for the indicated time. The reactor was cooled to r.t., the flask was opened to air and thereaction mixture was poured into water (20 mL), extracted with ethyl acetate (20 mL × 3), andorganic layer was washed with water (20 mL × 2) and once with brine (25 mL), dried overmagnesium sulfate and concentrated in vacuo. The product was purified by column chromatographyon silica gel using petroleum ether and ethyl acetate as eluent.1-(2-Methoxyphenyl)-1H-pyrrole (3a) [30]: colorless oil (0.43 g, 88%). 1H-NMR (400 MHz, CDCl3) delta (ppm):7.30-7.23 (2H, m), 7.03-6.98 (4H, m), 6.30 (2H,

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yuan, Chunling; Zhang, Lei; Zhao, Yingdai; Molecules; vol. 24; 22; (2019);,
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Sources of common compounds: 2-Bromobenzonitrile

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2042-37-7, name is 2-Bromobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H4BrN

General procedure: activityThe catalytic activities of the prepared catalysts were testedfor the Suzuki-Miyuara cross-coupling reaction of phenylboronicacid with various bromoarenes. In a typical experiment, 0.70 mmolof the aryl bromide, 1.5 molar equivalents of phenylboronic acidand 1.5 molar equivalents of base, respectively, and 1.3 mmol ofanisole (internal standard) were dissolved in 20 ml of solvent. 5 mgof the catalyst (corresponding to approximately 0.05 mol% palla-dium) were added. The reaction was carried out under stirring at 75C. To monitor the reaction progress, samples from the reac-tion solution (100 l) were taken after 15, 30, 60, 90 and 120 min.HPLC sample solutions were prepared by dissolving 100 l of thereaction solution in 1 ml of the initial mobile phase. HPLC analy-sis was done using an Agilent 1100 series HPLC system (Agilent,Waldbronn, Germany), equipped with an online degasser, qua-ternary pump, autosampler, thermostatted column compartmentand UV-vis diode array detector. An Agilent Poroshell 120 EC-C18 reversed-phase column (50 × 4.6 mm; 2.7 m) was used asstationary phase. Analysis was carried out under gradient elu-tion conditions using a mobile phase consisting of methanol andaqueous phosphoric acid (water: phosphoric acid = 300:1 v/v). Col-umn temperature was set to 25C. UV-detection was performed atwavelengths of 237 and 270 nm over a run time of 15 min.

The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lichtenegger; Maier; Hackl; Khinast; Goessler; Griesser; Kumar, V.S. Phani; Gruber-Woelfler; Deshpande; Journal of Molecular Catalysis A: Chemical; vol. 426; (2017); p. 39 – 51;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts