Category: 2042-37-7

Quality Control of 2-BromobenzonitrileIn 2021 ,《Arylbiamidines: synthesis and structural studies en route to anticancer applications》 was published in New Journal of Chemistry. The article was written by Grytsai, Oleksandr; Goncalves, Leticia Christina Pires; Bardovskyi, Rostyslav; Hamouda-Tekaya, Nedra; Rocchi, Stephane; Ronco, Cyril; Benhida, Rachid. The article contains the following contents:

Biamidines are a unique and poorly studied class of nitrogenous compounds prone to tautomerization and H-bonding. Four series of heteroaryl diarylbiamidines were synthesized and the antimelanoma activity and physicochem. properties of the resulting 37 new compounds were evaluated. The dimethylthiazolyl 3-bromophenyl biamidine derivative B6 (I) inhibits the growth of six different melanoma cell lines, having higher activity than the pos. control drug, the B-RAF inhibitor PLX4032. This study introduces diarylbiamidines as promising frameworks for drug discovery. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Quality Control of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lu, Wen-Xiu; Xing, Jian; Sun, Yijia; Huang, Qinge; Deng, Zhenwei; Mao, Jian-Gang published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Palladium-catalyzed and alcohol-enabled transformation to synthesize benzocyclic ketones》.Formula: C7H4BrN The article contains the following contents:

A highly effective palladium-catalyzed and alc.-promoted transformation of nitriles to synthesize benzocyclic ketones was described. It provided a straightforward access to potentially valuable indanone compounds in high yields in the presence of alc. It avoided the usage of carbon monoxide or an addnl. hydrolysis procedure. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Formula: C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Formula: C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rzhevskiy, Sergey A.; Topchiy, Maxim A.; Bogachev, Vasilii N.; Minaeva, Lidiya I.; Cherkashchenko, Ilia R.; Lavrov, Konstantin V.; Sterligov, Grigorii K.; Nechaev, Mikhail S.; Asachenko, Andrey F. published their research in Mendeleev Communications in 2021. The article was titled 《Solvent-free palladium-catalyzed C-O cross-coupling of aryl bromides with phenols》.Product Details of 2042-37-7 The article contains the following contents:

A new solvent-free procedure for C-O cross-coupling between phenols ArOH (Ar = Ph, 4-chlorophenyl, 2-isopropylphenyl, etc.) and aryl bromides Ar1Br (Ar1 = 4-methylphenyl, 2-cyanophenyl, 3,5-bis(trifluoromethyl)phenyl, etc.) comprising of Pd2(dba)3/ButBrettPhos catalytic system is efficient for substrates bearing donor or acceptor, as well as bulky substituents.2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Product Details of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Akkoc, Mitat; Bugday, Nesrin; Altin, Serdar; Yasar, Sedat published an article in 2021. The article was titled 《Magnetite@MCM-41 nanoparticles as support material for Pd-N-heterocyclic carbene complex: A magnetically separable catalyst for Suzuki-Miyaura reaction》, and you may find the article in Applied Organometallic Chemistry.Application In Synthesis of 2-Bromobenzonitrile The information in the text is summarized as follows:

The magnetite@MCM-41@NHC@Pd catalyst was obtained with Pd metal bound to the NHC ligand anchored to the surface of Fe3O4@MCM-41. It was characterized by Fourier transform IR (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), XPS, energy disperse X-ray anal. (EDX), thermogravimetric anal. (TGA), DTA, and SEM. The amount of Pd in the magnetite@MCM-41@NHC@Pd was measure by inductively coupled plasma-optical emission spectroscopy (ICP-OES) anal. The catalytic activity of magnetite@MCM-41@NHC@Pd heterogeneous catalyst done on Suzuki-Miyaura reactions of aryl halides with different substituted arylboronic acid derivatives All coupling reactions afforded excellent yields and up to 408404 turnover frequency (TOF) h-1 in the presence of 2 mg of magnetite@MCM-41@NHC@Pd catalyst (0.0564 mmol g-1, 0.01127 mmol% Pd) at room temperature in 2-propanol/H2O (1:2). Moreover, magnetite@MCM-41@NHC@Pd catalyst was recover by applying the magnet and reused for another reaction. The catalyst showed excellent structural and chem. stability and reused ten times without a substantial loss in its catalytic performance. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Application In Synthesis of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Altan, Orhan published an article in Applied Organometallic Chemistry. The title of the article was 《A rare example of the in-situ formation of palladium nanoparticles: The emergence of catalytically active palladium nanoparticles from Pd (II) phosphine complexes in the Suzuki-Miyaura coupling reaction》.Name: 2-Bromobenzonitrile The author mentioned the following in the article:

Pd (II) complexes of phosphino-benzaldoxime ligands were synthesized, characterized and tested in SMC reactions. Interestingly, it was found that the catalytic activity increased by 11 times when the amount of catalyst was reduced by 10-fold and increased by five times when the amount of catalyst was decreased by 100-fold. The detailed analyses revealed that the palladium nanoparticles (NPs) are responsible for the catalytic activity which was formed in the reaction medium. A plausible mechanism was proposed for the formation of Pd NPs from palladium phosphino-benzaldoxime complexes in the reaction medium. This study is expected to contribute to the debate over whether the catalytic activity of phosphine-palladium complexes in SMC reactions results from a homogeneous or heterogeneous pathway. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Choudhury, Shubhranshu Shekhar; Mahapatra, Shivam; Biswal, Himansu S. published an article in 2022. The article was titled 《Hydrogen bond mediated conversion of benzenenitriles and arylacetonitriles to amides: an “”on/in-water”” reaction strategy》, and you may find the article in Green Chemistry.COA of Formula: C7H4BrN The information in the text is summarized as follows:

Owing to the myriad of applications that amides have, hydration of nitriles has emerged as one of the most preferred atom-efficient synthesis methods. Being kinetically slow, this strategy requires some efficient catalysts. Herein, authors discovered choline hydroxide as an environmentally benign, metal-free and inexpensive catalyst for the hydration of aromatic and heteroaromatic nitriles on/in water with excellent yields. All the reactions proceeded under mild/moderate conditions, facilitated by the hydrogen bonds between the catalyst and the reactant or intermediate. D. functional theory (DFT) studies were used to propose the plausible reaction mechanism, which was further corroborated with kinetics measurements using quant. 19F NMR spectroscopy, thereby revealing the presence of H-bond mediated catalysis which brought down the activation energy barrier even lower than those in previous reports on using H2SO4 or Ru(OH)x/Al2O3 as catalysts. This work offers an “”on/in-water”” reaction strategy for the efficient hydration of nitriles and will pave the path towards novel routes for the com. synthesis of amides. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7COA of Formula: C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.COA of Formula: C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Moeini, Nazanin; Ghadermazi, Mohammad; Molaei, Somayeh published an article in Journal of Molecular Structure. The title of the article was 《Synthesis and characterization of magnetic Fe3O4@Creatinine@Zr nanoparticles as novel catalyst for the synthesis of 5-substituted 1H-tetrazoles in water and the selective oxidation of sulfides with classical and ultrasonic methods》.Reference of 2-Bromobenzonitrile The author mentioned the following in the article:

Tetrazoles and sulfoxide compounds have a wide range of applications in industries and are of great expectation to be environmentally friendly and cost-effective. This paper reports the introduction of zirconium supported on Fe3O4 nanoparticles through creatinine post-functionalization modification of Fe3O4 (Fe3O4@Creatinine@Zr). The Fe3O4@Creatinine@Zr was characterized by a vibrating sample magnetometer, X-ray powder diffractometry, Fourier transforms IR, scanning electron microscope, energy dispersive X-Ray anal., thermogravimetric anal., and inductively coupled plasma. Fourier transform-IR spectroscopy results confirmed that creatinine was successfully immobilized on the surface of Fe3O4-Cl with the presence of ν(C = N), and ν(C = O) bands of creatinine. X-ray diffraction data confirmed that the crystalline phase of Fe3O4 was not destroyed after modification. Vibrating sample magnetometer anal. showed that the saturation magnetization of the Fe3O4@Creatinine@Zr was 28.6 emu/g. The SEM-EDX results revealed that the zirconium complex was successfully incorporated into the structure of Fe3O4. This catalyst displayed high catalytic performance in the synthesis of 5-substituted 1H-tetrazoles and the selective oxidation of sulfides with classical and ultrasonic methods. The catalyst conferred strong Lewis’s acidity sites for the activity and selectivity of the reactions. The obtained results showed that the fast oxidation of sulfides occurred with 0.2 mmol g -1 of zirconium immobilized on the Fe3O4 nanoparticle at optimum condition (sulfide (1 mmol), H2O2 (0.6 mL), ethanol (3 mL) and catalyst (Fe3O4@Creatinine@Zr, 60 mg) at room temperature). The results showed that ultrasonic was an appropriate method for the oxidation of sulfides to the related sulfoxide at the optimum condition. The 5-substituted 1H-tetrazoles were afforded at optimum condition (nitrile (1 mmol), NaN3 (1.2 mmol), H2O (3 mL), catalyst (100 mg) at 90°C). The catalyst was separated by simple recovery and reused for seven cycles without any remarkable decrease in the catalysis activity and selectivity. The output of this research can open a window for the synthesis the other organic materials under mild condition. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Reference of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Reference of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 2-BromobenzonitrileIn 2022 ,《VU6036720: the first potent and selective in vitro inhibitor of heteromeric Kir4.1/5.1 inward rectifier potassium channels》 appeared in Molecular Pharmacology. The author of the article were McClenahan, Samantha J.; Kent, Caitlin N.; Kharade, Sujay V.; Isaeva, Elena; Williams, Jade C.; Han, Changho; Terker, Andrew; Gresham, Robert III; Lazarenko, Roman M.; Days, Emily L.; Romaine, Ian M.; Bauer, Joshua A.; Boutaud, Olivier; Sulikowski, Gary A.; Harris, Raymond; Weaver, C. David; Staruschenko, Alexander; Lindsley, Craig W.; Denton, Jerod S.. The article conveys some information:

Heteromeric Kir4.1/Kir5.1 (KCNJ10/KCNJ16) inward rectifier potassium (Kir) channels play key roles in the brain and kidney, but pharmacol. tools for probing their physiol. and therapeutic potential have not been developed. Here, we report the discovery, in a high-throughput screening of 80,475 compounds, of the moderately potent and selective inhibitor VU0493690, which we selected for characterization and chem. optimization. VU0493690 concentration-dependently inhibits Kir4.1/5.1 with an IC50 of 0.96 μM and exhibits at least 10-fold selectivity over Kir4.1 and ten other Kir channels. Multidimensional chem. optimization of VU0493690 led to the development of VU6036720, the most potent (IC50 = 0.24 μM) and selective (>40-fold over Kir4.1) Kir4.1/5.1 inhibitor reported to date. Cell-attached patch single-channel recordings revealed that VU6036720 inhibits Kir4.1/5.1 activity through a reduction of channel open-state probability and single-channel current amplitude. Elevating extracellular potassium ion by 20 mM shifted the IC50 6.8-fold, suggesting that VU6036720 is a pore blocker that binds in the ion-conduction pathway. Mutation of the “”rectification controller”” asparagine 161 to glutamate (N161E), which is equivalent to small-mol. binding sites in other Kir channels, led to a strong reduction of inhibition by VU6036720. Renal clearance studies in mice failed to show a diuretic response that would be consistent with inhibition of Kir4.1/5.1 in the renal tubule. Drug metabolism and pharmacokinetics profiling revealed that high VU6036720 clearance and plasma protein binding may prevent target engagement in vivo. In conclusion, VU6036720 represents the current state-of-the-art Kir4.1/5.1 inhibitor that should be useful for probing the functions of Kir4.1/5.1 in vitro and ex vivo. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Safety of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Safety of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic & Biomolecular Chemistry included an article by West, Matthew J.; Watson, Allan J. B.. Name: 2-Bromobenzonitrile. The article was titled 《Ni vs. Pd in Suzuki-Miyaura sp2-sp2 cross-coupling: a head-to-head study in a comparable precatalyst/ligand system》. The information in the text is summarized as follows:

Despite significant advances, ligand development for Ni-catalyzed Suzuki-Miyaura cross-coupling remains underdeveloped when compared to Pd and, as a consequence, ligands for Ni-catalyzed processes are typically taken from the Pd arena. In this study, the effect of using a similar Ni and Pd precatalyst based on a common bidentate ligand (dppf) in a head-to-head format was evaluated for the most common type of biaryl couplings, establishing the practical implications of direct replacement of Pd with Ni, and identifying the potential origins of these observations in a mechanistic context. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wen, Xiaoting; He, Jingxi; Xi, Hui; Zheng, Qi; Liu, Weiping published an article in 2022. The article was titled 《Hydration of Nitriles Enabled by PNP-manganese Pincer Catalyst》, and you may find the article in Asian Journal of Organic Chemistry.Quality Control of 2-Bromobenzonitrile The information in the text is summarized as follows:

A general and practical methodol. for the hydration of nitriles to primary amides enabled by manganese catalyst was presented. The described protocol showed broad substrate scope with good functional group tolerance, including a wide range of (hetero)aromatic and aliphatic nitriles, thus afforded the corresponding amides RC(O)NH2 [R = c-hexyl, Ph, 2-furyl., etc.] in good to excellent isolated yields under mild conditions. Preliminary mechanistic studies indicated that metal-ligand cooperation (MLC) mode was involved in this catalytic process. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Quality Control of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts