Category: 2042-37-7

《The direct C4-arylation of 3,5-dimethylisoxazole with aryl bromides catalyzed by imidazolidin-2-ylidene based palladium-PEPPSI complexes》 was published in Inorganica Chimica Acta in 2020. These research results belong to Kaloglu, Murat; Ozdemir, Ismail. HPLC of Formula: 2042-37-7 The article mentions the following:

In this study, the synthesis and characterization of four new imidazolinium salts as carbene precursors and their corresponding four new PEPPSI-type (PEPPSI = Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation) palladium complexes I (R = 4-Me, 2,4,6-tri-Me, 2,3,4,5,6-pentamethyl, 4-tert-butyl) were reported. The catalytic activities of all palladium complexes I were evaluated in the direct C4-arylation of 3,5-dimethylisoxazole with para-substituted aryl bromides 4-R1C6H4Br (R1 = H, Me, CHO, F, etc.), ortho-substituted aryl bromides 2-R2C6H4Br (R2 = Me, CN) and heteroaryl bromides R3Br (R3 = quinolin-3-yl, thiophen-2-yl). A range of functional groups such as methoxy, acetyl, formyl, fluoro, trifluoromethyl, nitrile or tert-Bu on the aryl bromides were successfully tolerated, and good yields were generally obtained in presence of 1 mol% catalyst loading at 120°C. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Palladium-catalyzed successive C-H bond arylations and annulations toward the π-extension of selenophene-containing aromatic skeletons》 were Shi, Xinzhe; Mao, Shuxin; Roisnel, Thierry; Doucet, Henri; Soule, Jean-Francois. And the article was published in Organic Chemistry Frontiers in 2019. HPLC of Formula: 2042-37-7 The author mentioned the following in the article:

A modular approach for the synthesis of planar π-extended selenium containing mols. from selenophene has been developed. Different combinations of Pd-catalyzed desulfitative C-H bond arylations with (2-bromo)arylsulfonyl chlorides R-2-BrC6H3SO2Cl (R = H, 4-CF3, 4-F, 5-CF3) and Pd-catalyzed intra- or/and inter-mol. C-H bond arylations with aryl bromides R1Br (R1 = 4-CNC6H4, 5-acetylthiophen-2-yl, 3-F3CC6H4, etc.) allowed the extension of the selenophene-containing aromatic skeleton at the [b]-, [c]- or [b:d]-junctions to give phenanthro[b]selenophenes, e.g. I, phenanthro[c]selenophenes, II (R2 = CN, NO2, OCH3, CF3; R3 = H, CF3) or diphenanthro[b:d]selenophenes III (R4 = H, CF3, CN; R5 = H, CF3). In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published an article in 2022. The article was titled 《Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol》, and you may find the article in Organic Chemistry Frontiers.Application of 2042-37-7 The information in the text is summarized as follows:

N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Application of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C-H Bond Arylations》 were Benzai, Amal; Shi, Xinzhe; Derridj, Fazia; Roisnel, Thierry; Doucet, Henri; Soule, Jean-Francois. And the article was published in Journal of Organic Chemistry in 2019. Synthetic Route of C7H4BrN The author mentioned the following in the article:

Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Ketoconazole. In the presence of phosphine-free Pd(OAc)2 catalyst, aryl bromides are efficiently coupled at the C5-position of the imidazole units, which are widely decorated. Under these conditions, only the C-H bond arylation reaction occurred without affecting the integrity of chem. structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole, Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Synthetic Route of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Gao, Hongjie; Chen, Jia-Yi; Peng, Zhiqiang; Feng, Lei; Tung, Chen-Ho; Wang, Wenguang published an article in Journal of Organic Chemistry. The title of the article was 《Bioinspired Iron-Catalyzed Dehydration of Aldoximes to Nitriles: A General N-O Redox-Cleavage Method》.Recommanded Product: 2-Bromobenzonitrile The author mentioned the following in the article:

An efficient iron catalyst, Cp*Fe(1,2-Cy2PC6H4O), which rapidly converts various aliphatic and aromatic aldoximes RCH=NOH [R = Pr, Ph, 2H-1,3-benzodioxol-5-yl, etc.] to nitriles RCN with release of H2O at room temp was reported. The catalysis involves redox activation of the N-O bond by a 1e- transfer from the iron catalyst to the oxime. Such redox-mediated N-O cleavage was demonstrated by the isolation of a ferrous iminato intermediate from the reaction of the ketoxime substrate. This iron-catalyzed acceptorless dehydration approach represents a general method for the preparation of nitriles, and it also delivers salicylonitriles R1CN(2-OH) [R1 = Ph, 3-methoxyphenyl, naphthalen-1-yl, etc.] catalyzing the Kemp elimination reaction. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 2042-37-7In 2021 ,《Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles》 appeared in Chemistry – An Asian Journal. The author of the article were Kim, Hyeongsu; Xuan, Zi; Hyun Kim, Ju. The article conveys some information:

An efficient tandem route to obtain tetrasubstituted NH pyrroles I (R = Me, Et, Bn; Ar = Ph, 2-naphthyl, pyridin-3-yl, etc.) in a one-pot manner has been developed, staring from simple nitriles ArCN, Et bromoacetates BrCH2CO2R, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles I in yields up to 91%. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Green synthesis of zirconium phosphate by combustion method: photocatalytic application and microwave-assisted catalytic conversion of aldehyde to nitriles》 was written by Shashank, M.; Bhojya Naik, H. S.; Shashikanth, J.; Nizam, Aatika; Nagaraju, G.. Electric Literature of C7H4BrNThis research focused onzirconium phosphate nanoparticle photocatalytic degradation. The article conveys some information:

Water pollution has increased swiftly, especially the dyes from industries that have disturbed aquatic eco-system. Photocatalytic degradation (PCD) is one of the attractive methods to eliminate dyes from industrial effluents. Zirconium phosphate (ZP) nanoparticles were synthesized by combustion method using zirconyl nitrate and phosphorous pentoxide as precursors. The obtained ZP was characterized by powder X-ray diffractogram, Fourier transform IR, SEM, high-resolution transmission electron microscopy, Raman spectroscopy, photoluminescence spectroscopy, Brunauer-Emmett-Teller surface area. PCD was carried out using methylene blue as a model pollutant in aqueous medium in the presence of UV light irradiation with different concentrations of dye, catalyst and pH. Higher degradation efficiency was observed in basic medium. ZP is employed as a catalyst to form nitrides from aldehydes using different solvents with different aldehydes. Graphic abstract: [graphic not available: see fulltext]. The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Electric Literature of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Electric Literature of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Garnes-Portoles, Francisco; Greco, Rossella; Oliver-Meseguer, Judit; Castellanos-Soriano, Jorge; Consuelo Jimenez, M.; Lopez-Haro, Miguel; Hernandez-Garrido, Juan Carlos; Boronat, Mercedes; Perez-Ruiz, Raul; Leyva-Perez, Antonio published an article in 2021. The article was titled 《Regioirregular and catalytic Mizoroki-Heck reactions》, and you may find the article in Nature Catalysis.Recommanded Product: 2-Bromobenzonitrile The information in the text is summarized as follows:

Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling. The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Hantzsch Ester as a Visible-Light Photoredox Catalyst for Transition-Metal-Free Coupling of Aryl halides and Arylsulfinates》 was published in Chemistry – A European Journal in 2020. These research results belong to Zhu, Da-Liang; Wu, Qi; Li, Hai-Yan; Li, Hong-Xi; Lang, Jian-Ping. Quality Control of 2-Bromobenzonitrile The article mentions the following:

Di-Et 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HEH) was utilized as a visible-light photoredox catalyst for the cross coupling of aryl halides and aryl sulfinates without transition metal, sacrificial agent and mediator. This method was compatible with various functional groups and provided diaryl sulfones in good to high yields. Mechanistic studies indicated that this reaction underwent the stepwise light irradiation of HE-, single electron transfer (SET) in donor-acceptor complex (DAC) from *HE- to aryl halide, trapping of aryl radical with sulfinate and SET oxidation of sulfone radical anion by HE. to sulfone by the DAC method. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Quality Control of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 2-BromobenzonitrileIn 2021 ,《Paired Electrolysis Enabled Ni-Catalyzed Unconventional Cascade Reductive Thiolation Using Sulfinates》 was published in Journal of Organic Chemistry. The article was written by Kang, Jun-Chen; Li, Zi-Hao; Chen, Chao; Dong, Li-Kun; Zhang, Shu-Yu. The article contains the following contents:

Herein, authors have reported a nickel-catalyzed cascade reductive thiolation of aryl halides with sulfinates driven by paired electrolysis. This protocol uses sulfinates as the sulfur source, and various thioethers could be synthesized under mild conditions. By mechanism exploration, authors find that a cascade chem. step is allowed on the electrode interface and could alter the reaction pathway in paired electrolysis, whose findings could help the discovery of novel cascade reactions with unique reactivity. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application In Synthesis of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts