Category: 2042-37-7

The author of 《Formation of Hetero-binuclear Pt(II)-M(II) Complexes Based on (2-(1H-Tetrazol-5-yl)phenyl)diphenylphosphine Oxide for Superior Phosphorescence of Monomers》 were Huang, Juan; Liu, Zhuo; Chen, Hui; Zhang, Hailing; Zhang, Han; Liu, Chunmei; Gao, Qin; Du, Chenxia; Zhang, Bin. And the article was published in Inorganic Chemistry in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

Novel hetero-binuclear platinum complexes (HBC-Pt(II)-M(II), M = Ca(II), Mg(II), Zn(II), and Cd(II)) have been synthesized by the reaction of the corresponding precursors [Pt(ppy)(μ-Cl)]2 with (2-(1H-tetrazol-5-yl)phenyl)diphenylphosphine oxide (TTPPO). The x-ray structures of the complexes show that two ancillary ligands TTPPO in the square-planar Pt(II) moiety act as a quadridentate chelating agent for the other metal center, eventually forming a distorted octahedral configuration. There are no significant π-π interactions and Pt-M metallophilic interactions in the crystal lattice, due to the steric hindrances associated with the rigid octahedral structure together with the bulky TTPPO. Consequently, HBC-Pt-M complexes show monomer emission characteristics with quantum yields up to 59% in powder, suggesting their great potential for practical applications. DFT and TD-DFT calculations on HBC-Pt-Zn reveal that the phosphorescence can be ascribed to intraligand charge transfer (3ILCT) combined with some metal-to-ligand charge transfer (3MLCT) in the Pt(ppy) moiety, which is consistent with the observations from the photophys. investigations. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Category: nitriles-buliding-blocks)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 2-BromobenzonitrileIn 2019 ,《Single-molecule photoredox catalysis》 appeared in Chemical Science. The author of the article were Haimerl, Josef; Ghosh, Indrajit; Koenig, Burkhard; Vogelsang, Jan; Lupton, John M.. The article conveys some information:

The chem. of life is founded on light, so is it appropriate to think of light as a chem. substance Planck’s quantization offers a metric analogus to Avogadro’s number to relate the number of particles to an effective reaction of single mols. and photons to form a new compound A rhodamine dye mol. serves as a dehalogenating photocatalyst in a consecutive photoelectron transfer (conPET) process which adds the energy of two photons, with the first photon inducing radical formation and the second photon triggering PET to the substrate mol. Rather than probing catalytic heterogeneity and dynamics on the single-mol. level, single-photon synthesis is demonstrated: the light quantum constitutes a reactant for the single substrate mol. in a dye-driven reaction. The approach illustrates that mol. diffusion and excited-state internal conversion are not limiting factors in conPET reaction kinetics because of catalyst-substrate preassocn. The effect could be common to photoredox catalysis, removing the conventional requirement of long excited-state lifetimes. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Chen; Yue, Huifeng; Rueping, Magnus published an article in 2022. The article was titled 《Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry》, and you may find the article in Nature Communications.Name: 2-Bromobenzonitrile The information in the text is summarized as follows:

A three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes was reported. A wide range of trisubstituted alkenes were obtained in good to high yields with excellent chemo- and stereoselectivity by switching between electrochem. and photocatalysis. The E isomer of the product was obtained exclusively when the reaction was conducted with electricity and nickel, while the Z isomer was generated with high stereoselectivity when photo- and nickel dual catalysts were used. Moreover, photo-assisted electrochem. enabled nickel catalyzed protocol was demonstrated to selectively deliver Z-trisubstituted alkenes without the addition of photocatalysts. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Desaintjean, Alexandre; Danton, Fanny; Knochel, Paul published their research in Synthesis in 2021. The article was titled 《Preparation of Functionalized Diorganomagnesium Reagents in Toluene via Bromine or Iodine/Magnesium-Exchange Reactions》.Quality Control of 2-Bromobenzonitrile The article contains the following contents:

A wide range of polyfunctionalized di(hetero)aryl- and dialkenyl-magnesium reagents were prepared in toluene within 10 to 120 min between -78°C and 25°C via an I/Mg- or Br/Mg-exchange reaction using reagents of the general formula R2Mg (R = sBu, Mes). Highly sensitive functional groups, such as triazene or nitro, were tolerated in these exchange reactions, enabling the synthesis of various functionalized (hetero)arene and alkene derivatives after quenching with several electrophiles including allyl bromides, acyl chlorides, aldehydes, ketones and aryl iodides. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Quality Control of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kaloglu, Murat; Kaloglu, Nazan; Ozdemir, Ismail published an article in 2021. The article was titled 《Palladium-PEPPSI-NHC Complexes Bearing Imidazolidin-2-Ylidene Ligand: Efficient Precatalysts for the Direct C5-Arylation of N-Methylpyrrole-2-Carboxaldehyde》, and you may find the article in Catalysis Letters.Reference of 2-Bromobenzonitrile The information in the text is summarized as follows:

The Pd-catalyzed direct arylation of pyrroles is an important research field for organic synthesis and catalysis chem. However, imidazolidin-2-ylidene based Pd-NHC complexes (NHC=N-heterocyclic carbene) have not yet been employed as catalysts for the direct C5 mono-arylation of C2-substituted N-methylpyrrole derivatives with aryl halides. Therefore, a report on the synthesis and characterization of new 1,3-bis(substituted benzyl) imidazolinium salts as carbene precursors, and their corresponding Pd-PEPPSI-NHC type complexes (PEPPSI=Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation) has been described. The catalytic properties of these complexes have been evaluated in the direct C5 mono-arylation of N-methylpyrrole-2-carboxaldehyde with a wide variety of (hetero)aryl halides. This environmentally attractive procedure has also been found to be tolerant to a wide variety of functional groups on the aryl halides such as formyl, acetyl, nitrile, fluoro or trifluoromethyl, and good yields have been obtained in presence of 1 mol% catalyst loading at 120°. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Reference of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Reference of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Weyhermueller, Thomas; Werle, Christophe published their research in ACS Catalysis in 2021. The article was titled 《A Molecular Iron-Based System for Divergent Bond Activation: Controlling the Reactivity of Aldehydes》.COA of Formula: C7H4BrN The article contains the following contents:

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein the authors describe an approach centered on an operationally simple iron-based system that-depending on the reaction conditions-selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron’s dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity based on the iron system’s ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system’s mol. environment can supply control over bond activation processes; thus, providing easy access to various products from primary building blocks. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7COA of Formula: C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.COA of Formula: C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic Letters included an article by Janot, Christopher; Palamini, Pierre; Dobson, Benjamin C.; Muir, James; Aissa, Christophe. SDS of cas: 2042-37-7. The article was titled 《Palladium-Catalyzed Synthesis of Bis-Substituted Sulfoxonium Ylides》. The information in the text is summarized as follows:

α-Aryl-α-alkoxycarbonyl methylsulfoxonium ylides such as PhC-(CO2R)S+(:O)Me2 (R = Me, Et, Ph, Me3SiCH2CH2, t-BuMe2SiOCH2CH2OCH2CH2OCH2CH2) were prepared by palladium-catalyzed cross-coupling of α-sulfoxonium-substituted esters with aryl bromides and triflates and iodobenzene in the presence of either Pd(PPh3)4 or Pd2(dba)3 and t-Bu3P or XPhos. Sulfoxonium ylides were prepared from nicergoline and from the triflate ester of estrone. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7SDS of cas: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.SDS of cas: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chemical Science included an article by Takale, Balaram S.; Thakore, Ruchita R.; Handa, Sachin; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Name: 2-Bromobenzonitrile. The article was titled 《A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water》. The information in the text is summarized as follows:

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki-Miyaura coupling of aryl halides RX (R = 2-O2NC6H4, 1-benzothiophen-2-yl, 2-fluoropyridin-3-yl, etc.; X = Cl, Br, I) and aryl boronic acids R1B(OH)2 (R1 = 4-ClC6H4, 1-benzofuran-2-yl, pyren-1-yl, etc.) to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst. This general methodol. has been applied to several targets in the pharmaceutical area. Multiple recyclings of the aqueous reaction mixture involving both the same as well as different coupling partners are demonstrated. Low temperature microscopy (cryo-TEM) indicates the nature and size of the particles acting as nanoreactors. Importantly, given the low loadings of Pd invested per reaction, ICP-MS analyses of residual palladium in the products show levels to be expected that are well within FDA allowable limits. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Photochemically-Mediated, Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamate Esters》 were Blackburn, J. Miles; Gant Kanegusuku, Anastasia L.; Scott, Georgia E.; Roizen, Jennifer L.. And the article was published in Organic Letters in 2019. SDS of cas: 2042-37-7 The author mentioned the following in the article:

A general method is described for the coupling of (hetero)aryl bromides with O-alkyl sulfamate esters. The protocol relies on catalytic amounts of nickel and photoexcitable iridium complexes and proceeds under visible light irradiation at ambient temperature This technol. engages a broad range of simple and complex O-alkyl sulfamate ester substrates under mild conditions. Furthermore, it is possible to avoid undesirable N-alkylation, which was found to plague palladium-based protocols for N-arylation of O-alkyl sulfamate esters. These investigations represent the first use of sulfamate esters as nucleophiles in transition metal-catalyzed C-N coupling processes. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7SDS of cas: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.SDS of cas: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zhang, Cheng; Chen, Qian; Wang, Lei; Sun, Qiaoying; Yang, Yangyang; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K. published an article in Science China: Chemistry. The title of the article was 《Practical and modular construction of benzo[c]phenanthridine compounds》.COA of Formula: C7H4BrN The author mentioned the following in the article:

Herein, a general and modular strategy for the rapid assembly of benzo[c]phenanthridine (BCP) derivatives I [R = tBu, adamantan-1-yl; R1 = H, 9-Me, 8-OMe, etc.; R2 = H, 3-F, 2-OMe, etc.], II [R3 = tBu, Ph, 3-furyl, etc.] using homogeneous gold catalysis was described. Notably, in contrast to traditional methods based on the specially preformed substrates that had an inherent preference for the formation of this class of compounds with limited flexibility, this protocol was achieved via a selectively intramol. cascade of a diazo-tethered alkyne and subsequently an intermol. cyclization with a nitrile to facilitate the successive C-N and C-C bonds formation. This methodol. used readily available nitriles as the nitrogen source to deliver the products I and II in good yield with excellent functional group compatibility. A preliminary anti-tumor activity study of these generated products exhibitd high anticancer potency against five tumor cell lines, including HeLa, Mel624, SW-480, 8505C and LAN-1. Besides, a catalyst-controlled intermol. cycloaddition/intramol. insertion of the substrate with a fulvene to provide fused polycarbocycles containing a seven-membered ring III [R4 = Ph, 3-thienyl, 2-naphthyl, etc.; R5 = H, 11-OMe] was reported.2-Bromobenzonitrile(cas: 2042-37-7COA of Formula: C7H4BrN) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.COA of Formula: C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts