Category: 2042-37-7

In 2022,Wu, Mei; Huang, Sheng; Hou, Huiqing; Lin, Jie; Lin, Mei; Zhou, Sunying; Zheng, Zhiqiang; Sun, Weiming; Ke, Fang published an article in RSC Advances. The title of the article was 《DIPEA-induced activation of OH- for the synthesis of amides via photocatalysis》.Computed Properties of C7H4BrN The author mentioned the following in the article:

Herein, an efficient light-mediated strategy for the synthesis of amides in which a weak organic base acts as a reductant to induce the formation of OH- from water under metal-free conditions was reported. A mechanistic study revealed that the generation of an N,N-diisopropylethylamine (DIPEA) radical via single electron transfer (SET), with the assistance of photocatalyst, that increased the nucleophilicity of the water mols. with respect to the cyanides was essential. Moreover, the removal rate of nitrile in wastewater can be as high as 83%, indicating that this strategy had excellent potential for nitrile degradation In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Computed Properties of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Computed Properties of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Blockage detection and diagnosis of externally parallelized monolithic microreactors》 were Tonomura, Osamu; Taniguchi, Satoshi; Nishi, Kazuki; Nagaki, Aiichiro; Yoshida, Jun-ichi; Hirose, Katsuyuki; Ishizuka, Norio; Hasebe, Shinji. And the article was published in Catalysts in 2019. Recommanded Product: 2-Bromobenzonitrile The author mentioned the following in the article:

To realize stable operation of a microchem. system, it is necessary to develop a process monitoring method that can detect and diagnose blocked microreactors. In this study, a system composed of five monolithic microreactors and a split-and-recombine-type flow distributor (SRFD) was developed for Suzuki-Miyaura coupling. Firstly, the effects of operating conditions on the yield was examined by using a single microreactor. After that, an optimal design problem was formulated to maximize the blockage detection performance by adjusting the channel resistances of the SRFD and the sensor locations in the SRFD under the design constraints. To efficiently solve the problem, a pressure drop compartment model, which is analogous to elec. resistance networks, was used. The optimally designed system was exptl. evaluated from the viewpoint of the capability of continuous operation and the blockage detection and diagnosis performance. The evaluation results show that continuous operation was successfully carried out for one hour, and that the artificially generated blockage of each microreactor was accurately identified. The developed system minimized the process performance degradation due to blockage. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Saikat; Murugesan, Kathiravan; Villegas Rodriguez, Gonzalo J.; Kaur, Jaspreet; Barham, Joshua P.; Savateev, Aleksandr; Antonietti, Markus; Koenig, Burkhard published their research in ACS Catalysis in 2021. The article was titled 《Photocatalytic (Het)arylation of C(sp3)-H Bonds with Carbon Nitride》.Reference of 2-Bromobenzonitrile The article contains the following contents:

Mesoporous graphitic carbon nitride(mpg-CN)as a heterogeneous organic semiconductor photocatalyst for direct arylation of sp3 C-H bonds in combination with nickel catalysis are reported. This protocol has a broad synthetic scope (>70 examples including late-stage functionalization of drugs and agrochems.), was operationally simple, and shows high chemo- and regioselectivities. Facile separation and recycling of the mpg-CN catalyst in combination with its low preparation cost, innate photochem. stability, and low toxicity are beneficial features overcoming typical shortcomings of homogeneous photocatalysis. Detailed mechanistic investigations and kinetic studies indicate that an unprecedented energy-transfer process (EnT) from the organic semiconductor to the nickel complex was operated. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Reference of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Reference of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Suzuka, Toshimasa; Niimi, Ryoko; Uozumi, Yasuhiro published an article in Synlett. The title of the article was 《Cyanide-Free Cyanation of Aryl Iodides with Nitromethane by Using an Amphiphilic Polymer-Supported Palladium Catalyst》.Synthetic Route of C7H4BrN The author mentioned the following in the article:

A cyanide-free aromatic cyanation was developed that used nitromethane as a cyanide source in water with an amphiphilic polystyrene-poly(ethylene glycol) resin-supported palladium catalyst and an alkyl halide (1-iodobutane). The cyanation proceeded through the palladium-catalyzed cross-coupling of an aryl halide with nitromethane, followed by transformation of the resultant (nitromethyl)arene intermediate into a nitrile by 1-iodobutane. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Synthetic Route of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Yunhui; Luo, Hang; Zheng, Wanyao; Matsunaga, Shigeki; Lin, Luqing published an article in 2022. The article was titled 《Light-Promoted Nickel-Catalyzed Aromatic Halogen Exchange》, and you may find the article in ACS Catalysis.Recommanded Product: 2042-37-7 The information in the text is summarized as follows:

Visible-light-induced, single nickel-catalyzed halogen exchange of aromatic halides ArX (Ar = 4-chlorophenyl, naphthalen-1-yl, 1H-indol-7-yl, etc.; X = Cl, Br, I) with the corresponding halide salts such as sodium iodide, tetrabutylammonium bromide, benzyltriethylammonium chloride under mild conditions was reported. Varieties of aryl iodides ArI, bromides ArBr, and chlorides ArCl can smoothly undergo aromatic Finkelstein or retro-Finkelstein reactions with good functional group tolerance. Exptl., mechanistic studies showed that excited-state NiII complexes for facile reductive elimination to form carbon-halide bonds were involved in the process of Finkelstein and retro-Finkelstein reactions. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Recommanded Product: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zheng, Haoteng; Xiao, Qinjie; Mao, Feiying; Wang, Anming; Li, Mu; Wang, Qiuyan; Zhang, Pengfei; Pei, Xiaolin published an article in RSC Advances. The title of the article was 《Programing a cyanide-free transformation of aldehydes to nitriles and one-pot synthesis of amides through tandem chemo-enzymatic cascades》.Safety of 2-Bromobenzonitrile The author mentioned the following in the article:

In this work, a greener chemo-enzymic cascade to synthesize alky and aryl nitriles RCN (R = Ph, Bn, pentyl, furan-2-yl, etc.) from readily accessible aldehydes RCHO, that were further transformed into corresponding amides RC(O)NH2 via an artificial enzyme cascade was reported. A biphasic reaction system was designed to bridge chem. synthesis and enzymic catalysis through simple phase separation The biphasic system mainly perfectly avoided the inactivation of hydroxylamine on aldoxime dehydratase from Pseudomonas putida (OxdF1) and nitrile hydratase from Aurantimonas manganoxydans ATCC BAA-1229 (NHase1229). For the synthesis of various nitriles, moderate isolation yields of approx. 60% were obtained by the chemo-enzymic cascade. Interestingly, two seemingly conflicting reactions of dehydration and hydration were sequentially proceeded to synthesize amides by the synergistic catalysis of OxdF1 and NHase1229 in E. coli cells. An isolation yield of approx. 62% was achieved for benzamide at the one-liter scale. In addition, the shuttle transport of substrates and products between two phases is convenient for the product separation and n-hexane recycling. Thus, the chemo-enzymic cascade shows a potential application in the cyanide-free and large-scale synthesis of nitriles and amides. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Safety of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Safety of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cardenas, Jorge; Gavino, Ruben; Garcia-Rios, Erendira; Rios-Ruiz, Lucero; Puello-Cruz, Ana C.; Morales-Serna, Francisco Neptali; Gomez, Samuel; Lopez-Torres, Adolfo; Morales-Serna, Jose Antonio published their research in RSC Advances in 2021. The article was titled 《The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(II) complex and toxicity of the ligand precursor for the marine benthic copepod Amphiascoides atopus》.Synthetic Route of C7H4BrN The article contains the following contents:

The palladium-catalyzed reaction of aryl halides and allylic alcs. was an attractive method for obtaining α,β-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(II) complex formed in situ was found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcs., with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(II) complex for the harpacticoid copepod Amphiascoides atopus allowed to contrast the efficiency of the catalytic system with the potential impact of the principal waste chem. in global aquatic ecosystems, which has not been previously addressed. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Synthetic Route of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Continuous flow Suzuki-Miyaura couplings in water under micellar conditions in a CSTR cascade catalyzed by Fe/ppm Pd nanoparticles》 was published in Green Chemistry in 2020. These research results belong to Wood, Alex B.; Nandiwale, Kakasaheb Y.; Mo, Yiming; Jin, Bo; Pomberger, Alexander; Schultz, Victor L.; Gallou, Fabrice; Jensen, Klavs F.; Lipshutz, Bruce H.. Synthetic Route of C7H4BrN The article mentions the following:

The first demonstration of aqueous surfactant-enabled Suzuki-Miyaura couplings run under flow conditions was described. In addition, use of an even more challenging heterogeneous nanoparticle catalyst, containing only 800 ppm of Pd (i.e., 0.08 mol%) in the form of Fe/ppm Pd nanoparticles, was sufficient using a continuous stirred-tank reactor (CSTR). In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Synthetic Route of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Wang, Qiao-Lin; Sun, Zhaozhao; Huang, Huawen; Mao, Guojiang; Deng, Guo-Jun published an article in Green Chemistry. The title of the article was 《Stoichiometric couplings of methylarenes through visible-light-induced bromo radical formation from aryl halides》.Application In Synthesis of 2-Bromobenzonitrile The author mentioned the following in the article:

A visible-light/nickel dual catalyzed stoichiometric coupling of methylarenes via bromine radical-enhanced HAT was developed. Aryl bromides serve as both cross-coupling partners and bromine radical precursors. Mechanistic studies revealed that the bromine radical acts as a highly efficient HAT reagent to abstract the benzylic C(sp3)-H bond to deliver a benzylic radical and subsequently engages in Ni-catalyzed arylation couplings. The synthetic utility of this approach was further proved by its application in the late-stage arylation or benzylation of several drug-like and complex mols. in a stoichiometric manner. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Application In Synthesis of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Akkoc, Mitat; Bugday, Nesrin; Altin, Serdar; Ozdemir, Ismail; Yasar, Sedat published an article in Catalysis Letters. The title of the article was 《Highly Active Fe3O4@SBA-15@NHC-Pd Catalyst for Suzuki-Miyaura Cross-Coupling Reaction》.Computed Properties of C7H4BrN The author mentioned the following in the article:

A novel Pd-NHC functionalized magnetic Fe3O4@SBA-15@NHC-Pd catalyst was synthesized and used as an efficient heterogeneous catalyst in the Suzuki-Miyaura C-C bond formation reactions. The Fe3O4@SBA-15@NHC-Pd characterized by X-Ray Diffraction (XRD), XPS, Fourier Transform IR (FTIR) spectroscopy, SEM (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray anal. (EDX), Thermogravimetric Anal. (TGA), DTA (DTA). The Inductively Coupled Plasma-Optical emission spectroscopy (ICP-OES) anal. was used to determine the exact amount of Pd (0.33 wt%) in Fe3O4@SBA-15@NHC-Pd. The TEM images of the catalyst showed the existence of palladium nanoparticles immobilized in the catalyst’s structure, while no reducing agent was used. The NHC moieties in the catalyst structure could be stabilize Pd(0) nanoparticles prevents agglomeration. The magnetic catalyst was effectively used in the Suzuki-Miyaura cross-coupling reaction of substituted phenylboronic acid derivatives with (hetero)aryl bromides in the presence of a potassium carbonate at room temperature in aqueous media and magnetic catalyst could be simply extracted from the reaction mixture by an external magnet. Different aryl bromides were converted to coupled-products Ar1Ar2 [Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; Ar2 = Ph, 2-MeC6H4, 1-naphthyl, etc.] in excellent yields with spectacular TOFs values (up to 1,960,339 h-1); in the presence of 1 mg of Fe3O4@SBA-15@NHC-Pd catalyst (contains 3.1 x 10-6 mol% Pd) at room temperature in aqueous media. After reusability experiments, it was found that this catalyst was effectively used up to ten times in the reaction with almost consistent catalytic efficiency. A decrease in the activity of the 10th reused catalyst was found as 9%. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Computed Properties of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Computed Properties of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts