Category: 204078-32-0

Reddy, P. Linga published the artcileCu(0)@Al2O3/SiO2 NPs: an efficient reusable catalyst for the cross coupling reactions of aryl chlorides with amines and anilines, Synthetic Route of 204078-32-0, the main research area is amine preparation green chem; aryl chloride amine copper nanocatalyst cross coupling reaction; alumina silica support copper nanoparticle catalyst preparation.

The C-N cross coupling reaction of aryl chlorides with various alkyl/aryl amines catalyzed by copper nanoparticles impregnated on alumina/silica support (Cu(0)@Al2O3/SiO2) was investigated. The prepared catalyst was characterized for its intrinsic physico-chem. and textural properties using XRD, XPS, HR-TEM, BET surface area, SEM-EDAX, H2-TPR and ICP-AES techniques. The catalyst exhibited excellent reactivity and efficacy in the cross-coupling of a wide range of alkyl/aryl amines including challenging anilines with aryl chlorides. The catalyst offers significant advantages such as brevity, milder reaction conditions, excellent yields and high functional group tolerance for C-N cross coupling when compared with the other reported methods. This atom-economical methodol. does not require an addnl. ligand or co-catalyst/activator. The Cu(0)@Al2O3/SiO2 catalyst was efficiently applied to a gram scale synthesis of 7-chloro-4-(4-(2-nitrophenyl)piperazin-1-yl)quinolone. The robustness of the catalyst was examined by reusing it for five consecutive runs.

RSC Advances published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Synthetic Route of 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Jingwei published the artcileCatalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, HPLC of Formula: 204078-32-0, the main research area is arylamine selective oxidative bond cleavage photochem catalyst free.

Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on authors’ well-designed C-C single bond cleavage mechanism, authors discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2 as a benign oxidant under very mild conditions. The utility of methodol. was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, this methodol. is noteworthy, not only it does not require any catalysts, but also it provides valuable possibilities for the scalable functionalization of clin. drugs and natural products.

Green Chemistry published new progress about C-C bond cleavage (photochem.). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, HPLC of Formula: 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hendrick, Charles E. published the artcileInsertion of Arynes into N-Halo Bonds: A Direct Approach to o-Haloaminoarenes, Quality Control of 204078-32-0, the main research area is haloaminoarene regioselective preparation; insertion aryne nitrogen halo bond.

A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives E.g., treating morpholine with NCS, followed by addition of 2-(trimethylsilyl)phenyl triflate and CsF, gave 67% o-haloaminoarene derivative (I).

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (halo). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Quality Control of 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Perez-Medrano, Arturo published the artcileSynthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine as P2X7 antagonists, Recommanded Product: 2-Morpholinobenzonitrile, the main research area is benzyl dichlorophenyl tetrazol amine preparation P2X7 antagonist human.

Synthesis and biol. evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the human and rat P2X7 receptors. On the benzyl moiety, a variety of functional groups were tolerated, including both electron-withdrawing and electron-donating substituents. Ortho-substitution on the benzyl group provided the greatest potency. The ortho-substituted analogs showed approx. 2.5-fold greater potency at human compared to rat P2X7 receptors.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Recommanded Product: 2-Morpholinobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts