Category: 20099-89-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 20099-89-2

Step-I: 4-(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile (XI-10-I) A mixture of 2,6-diaminopyrimidin-4-ol (1 g, 7.93 mmol) and NaOAc (0.846 g, 10.31 mmol) in water (180 mL) was heated to 100 C. for 20 minutes. To this was added a suspension of 4-(2-bromoacetyl)benzonitrile (2.2 gm, 8.73 mmol) [prepared according to procedure mentioned in J. Med. Chem., 2011, 54(12), 4042-4056] in MeOH (25 mL) and heated overnight at 100 C. After completion of reaction, the reaction mixture was cooled to 0 C. Resultant solid product was filtered off and dried under reduced pressure to provide title compound XI-10-I (1.2 g, 100%). LCMS: m/z 252 (M+1)+.

According to the analysis of related databases, 20099-89-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim; Kurhade, Santosh; Munot, Yogesh; Mengawade, Tanaji; Kulkarni, Bheemashankar A.; US2015/64196; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H6BrNO

2-Aminopyridine (1.88 g) and 2-bromo-4′-cyanoacetophenone (4.48 g) were dissolved in ethanol (40 mL), and sodium hydrogencarbonate (1.85 g) was added to the solution, followed by refluxing for 10 hours. Water was added to the reaction mixture, and the mixture was extracted with chloroform, followed by drying over magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to flash column chromatography. Fractions eluted by dichloromethane-methanol (100 : 1) were concentrated under reduced pressure, and the solid was recovered through filtration by use of diethyl ether, to thereby yield 4-imidazo[1,2-a]pyridin-2-ylbenzonitrile (3.82 g). 1H-NMR(400MHz,DMSO-d6)delta:6.94(1H,tt,J=1.0,6.8Hz), 7.30(1H,ddt,J=1.0,6.8,9.0Hz),7.62(1H,d,J=9.0Hz), 7.90(2H,d,J=8.5Hz),8.16(2H,d,J=8.5Hz), 8.56(1H,ddd,J=1.0,2.0,6.8Hz),8.60(1H,s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Fujifilm RI Pharma Co., Ltd.; Daiichi Sankyo Company, Limited; EP1956013; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 20099-89-2, These common heterocyclic compound, 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of olefin (0.5 mmol) and tween-80 (30 mL) in water (3 mL) was added DBH (214.5 mg, 0.75 mmol) at room temperature, and the mixture was stirred under the conditions as indicated in Table 1. After cooling to room temperature and removal of solvent under reduced pressure, EtOH (3 mL), thiourea (57.1 mg, 0.75 mmol) (or 0.75 mmol of N-methylthiourea/N-phenethylthiourea) were added to the mixture, and the obtained mixture was stirred for 2 h at 80 C. The mixture was diluted with ethyl acetate (60 mL). The organic phase was washed with brine (10mL x 3) and dried over Na2SO4. After concentrated under reduced pressure, the residue was purified by preparative thin layer chromatography to afford the corresponding 2-aminothiazoles.

Statistics shows that 4-(2-Bromoacetyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 20099-89-2.

Reference:
Article; Ma, Chunhua; Miao, Yuqi; Zhao, Minghao; Wu, Ping; Zhou, Jianglu; Li, Zhi; Xie, Xilei; Zhang, Wei; Tetrahedron; vol. 74; 27; (2018); p. 3602 – 3607;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 20099-89-2,Some common heterocyclic compound, 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, molecular formula is C9H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 1a or 1b (0.001 mol) in acetone (10 mL), an appropriate substituted 2-bromoacetophenone derivative (0.001 mol) and potassium carbonate (0.138 g, 0.001 mol) were reuxed at 40 C for 12 h. The solvent was evaporated, residue was washed with water, dried and recrystallized from ethanol. The mass spectra of the compounds (3a-p) are available in the Supplementary Materials.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(2-Bromoacetyl)benzonitrile, its application will become more common.

Reference:
Article; Cevik, Ulviye Acar; Saglik, Beguem Nurpelin; Levent, Serkan; Osmaniye, Derya; Cavu?oglu, Betul Kaya; Ozkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 24; 5; (2019);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts