Category: 199536-01-1

Dahmen, Claudia published the artcileImproving implant materials by coating with nonpeptidic, highly specific integrin ligands, Related Products of nitriles-buliding-blocks, the main research area is diacyl hydrazine preparation integrin ligand implant coating.

Osteoblast adhesion to titanium, a common material for implants, is stimulated by coating with an optimized and highly specific nonpeptidic ligand for the αvβ3 integrin. This new technol. is advantageous to conventional coating by peptides or proteins in many practical aspects (selectivity and activity, stability against enzymic degradation, sterilization, costs).

Angewandte Chemie, International Edition published new progress about Bioadhesion. 199536-01-1 belongs to class nitriles-buliding-blocks, name is Methyl 3-amino-5-cyanobenzoate, and the molecular formula is C9H8N2O2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bulyszko, Ilona published the artcileEvaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei, HPLC of Formula: 199536-01-1, the main research area is Amycolatopsis AHBA knockout mutant mutasynthesis; antibiotics; azides; mutasynthesis; natural products; polyketide synthase.

Supplementing an AHBA(-) mutant strain of Amycolatopsis mediterranei, the rifamycin producer, with a series of benzoic acid derivatives yielded new tetraketides containing different Ph groups. These mutasynthetic studies revealed unique reductive properties of A. mediterranei towards nitro- and azidoarenes, leading to the corresponding anilines. In selected cases, the yields of mutaproducts (fermentation products isolated after feeding bacteria with chem. prepared analogs of natural building blocks) obtained are in a range (up to 118 mg L-1) that renders them useful as chiral building blocks for further synthetic endeavors. The configuration of the stereogenic centers at C6 and C7 was determined to be 6R,7S for one representative tetraketide. Importantly, processing beyond the tetraketide stage is not always blocked when the formation of the bicyclic naphthalene precursor cannot occur. This was proven by formation of a bromo undecaketide, an observation that has implications regarding the evolutionary development of rifamycin biosynthesis.

Chemistry – A European Journal published new progress about Amycolatopsis mediterranei. 199536-01-1 belongs to class nitriles-buliding-blocks, name is Methyl 3-amino-5-cyanobenzoate, and the molecular formula is C9H8N2O2, HPLC of Formula: 199536-01-1.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chand, Pooran published the artcileDesign and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design, Safety of Methyl 3-amino-5-cyanobenzoate, the main research area is benzoic acid derivative preparation neuraminidase inhibitor; structure activity benzoic acid neuraminidase inhibitor; crystal structure benzoic acid neuraminidase complex; influenza neuraminidase inhibitor benzoic acid preparation.

A series of 94 benzoic acid derivatives were synthesized and tested for their ability to inhibit influenza neuraminidase. The enzyme-inhibitor complex structure was determined by x-ray crystallog. anal. for compounds which inhibited the enzyme. The most potent compound tested in vitro, (4-(acetylamino)-3-guanidinobenzoic acid) (I), had an IC50 = 2.5 × 10-6 M against N9 neuraminidase. Compound I was oriented in the active site of the neuraminidase in a manner that was not predicted from the reported active site binding of GANA (II) with neuraminidase. In a mouse model of influenza, I did not protect the mice from weight loss due to the influenza virus when dosed intranasally.

Journal of Medicinal Chemistry published new progress about Structure-activity relationship (neuraminidase-inhibiting). 199536-01-1 belongs to class nitriles-buliding-blocks, name is Methyl 3-amino-5-cyanobenzoate, and the molecular formula is C9H8N2O2, Safety of Methyl 3-amino-5-cyanobenzoate.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 199536-01-1, A common heterocyclic compound, 199536-01-1, name is Methyl 3-amino-5-cyanobenzoate, molecular formula is C9H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

CH3SO2Cl (40 mmol) was added to the solution of methyl-3-amine-5-cyanobenoate (10 mmol), pryridine (50 mmol) and DMAP (1 mmol) in DCM (150 mL). The solution was then heated to reflux for 4 hours. After cooling, diluted hydrochloric acid was poured into the solution. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The crude product was purified by column chromatography to afford methyl-3-cyano-5-(methylsulfonamido)benoate in 70% yield.

The synthetic route of 199536-01-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hutchison Medipharma Enterprises Limited; US2009/118292; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts