A common compound: 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 19924-43-7
General procedure: Anhydrous THF (25 mL) solution of 2a (0.40 g, 3.42 mmol) was stirred for 1 h at r.t., then N-butyl-4-bromo-1,8-naphthalimide(1, 1.00 g, 3.02 mmol) was added. After completion, the reaction mixture was quenched with HCl (15%) until pH 2-3. The organic fraction was extracted with EtOAc (3 ¡Á 20 mL), dried over anhydrous Na2SO4, and filtered. Volatile fractions were removed under reduced pressure, and the residual material was purified by flash column chromatography on silica gel (PE-EtOAc, 25:1) to provide 3a as a pink solid 0.80 g (72% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 19924-43-7, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Chen, Jinju; Liu, Chuanxiang; Guan, Fengjie; Zhang, Chuanxiu; Ji, Kai; Wang, Xinyu; Xu, Min; Wu, Fanhong; Synlett; vol. 26; 5; (2015); p. 609 – 612;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts