Category: 198203-94-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 198203-94-0, name is 2-Fluoro-3-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Fluoro-3-methoxybenzonitrile

2- fluoro-3-methoxybenzonitrile (500 mg, 3.31 mmol) was dissolved in methanol (40 mL). This solution was cooled to 0 C. Nickel (II) chloride hexahydrate (79 mg, 0.33 mmol) and di-tertbutyl dicarbonate (1.44g, 6.62mmol) were added followed by sodium borohydride (876 mg, 23.16 mmol) portionwise. The reaction mixture was stirred, allowed to warm to rt and stirred for 3 days. The MeOH was removed in vacuo. The residue was dissolved in CHCI3 (150 mL), washed with sat NaHC03 (aq) (50 mL), water (50mL), brine (50mL), dried (Na2S04) and evaporated in vacuo. The residue was purified by chromatography (silica), eluent 20% EtOAc / 80% Pet. Ether, to give a white solid identified as (2-fluoro-3-methoxybenzyl)-carbamic acid tert-butyl ester (540 mg, 0.2 mmol, 64% yield). [MH]+ = 255.8

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; DAVIE, Rebecca Louise; EDWARDS, Hannah Joy; EVANS, David Michael; HODGSON, Simon Teanby; PETHEN, Stephen John; ROOKER, David Philip; (139 pag.)WO2017/207983; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 198203-94-0, name is 2-Fluoro-3-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Fluoro-3-methoxybenzonitrile

2-Fluoro-3-methoxybenzonitrile (500 mg, 3.31 mmol) was dissolved in methanol (40 mL). This solution was cooled to 0 C. Nickel (II) chloride hexahydrate (79 mg, 0.33 mmol) and di-tertbutyl dicarbonate (1.44g, 6.62mmol) were added followed by sodium borohydride (876 mg, 23.16 mmol) portionwise. The reaction mixture was stirred, allowed to warm to rt and stirred for 3 days. The MeOH was removed in vacuo. The residue was dissolved in CHCl3 (150 mL), washed with sat NaHCO3 (aq) (50 mL), water (50mL), brine (50mL), dried (Na2SO4) and evaporated in vacuo. The residue was purified by chromatography (silica), eluent 20% EtOAc / 80% Pet. Ether, to give a white solid identified as (2-fluoro-3-methoxy-benzyl)- carbamic acid tert-butyl ester (540 mg, 0.2 mmol, 64% yield). [MH]+ = 255.8

According to the analysis of related databases, 198203-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; DAVIE, Rebecca Louise; EDWARDS, Hannah Joy; EVANS, David Michael; HODGSON, Simon Teanby; (0 pag.)WO2016/83820; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts