Category: 1953-99-7

A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1953-99-7.

.60 g (0.015 mol) of sodium hydroxide was added to a solution of 1.64 g (0.0075 mol) of 2,6-dichloro-4-nitroaniline in 40 mL of DMF, followed by addition of 2 g (0.0075 mol) of 3,4,5,6-tetrachlorophthalonitrile under stirring, the mixture was stirred for 5 h after addition at room temperature. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washed with water and saturated brine, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column (ethyl acetate/petroleum ether (boiling point range 60-90¡ã C.)=1:4, as an eluent) to give 2.8 g of compound A-44 as yellow solid, m.p. 188-190¡ã C. [0129] 1H-NMR (300 MHz, internal standard TMS, solvent CDCl3), delta (ppm): 6.76 (s, 1H, NH), 8.31 (s, 2H, Ph-3,5-2H).

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD.; SINOCHEM CORPORATION; Liu, Changling; Huang, Guang; Lan, Jie; Hao, Shulin; Li, Zhinian; Li, Huichao; Guan, Aiying; Jiang, Airu; Xu, Ying; US2014/213598; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3,4,5,6-Tetrachlorophthalonitrile (10 g), Potassium carbonate (10 g), Dodecane thiol (10 g) and Tetrahydrofuran (100 ml) were added to a 500 ml flask and reacted at room temperature for 2 hours.After completion of the reaction, the reaction mixture was filtered and vacuum distilled, and then hexane (100 mL) was added thereto for purification and filtration to obtain 4-dodecathio-3,5,6-trichlorophthalonitrile (11 g).

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SD I Co., Ltd.; Park, In Kul; Kim, Hyung Mook; Park, Chae Won; Sin, Myung Yeop; Lee, Young Gi; Jung, Uii Soo; (31 pag.)KR2016/47824; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts