Category: 1953-99-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1953-99-7 as follows. Quality Control of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

General procedure: To a 250 mL flask was added 4-dodecathio-3,5,6-Trichlorophthalonitrile (4.3 g), 3,4,5,6-Tetrachlorophthalonitrile (8.0 g), Diazabicycloundec-7-ene (4.5 g),1-Pentanol (80 mL) was added and the solid was dissolved by heating,Zinc acetate (1.8g) And reflux while heating.After completion of the reaction,Removed, Purify by column chromatography.Dichloromethane was appropriately added to the obtained solid to dissolve the solid, followed by addition of methanol to crystallize the solid. The obtained solid was filtered and dried under vacuum to obtain a compound represented by the following Chemical Formula 4-1. To a 250 mL flask was added 4-dodecathio-3,5,6-Trichlorophthalonitrile (4.3 g)3,4,5,6-Tetrachlorophthalonitrile (8.0 g) Instead, 4-dodecathio-3,5,6-Trichlorophthalonitrile (8.6 g)3,4,5,6-Tetrachlorophthalonitrile (5.3 g)Was obtained in the same manner as in Synthesis Example 1, except thatTo obtain the indicated compound.

According to the analysis of related databases, 1953-99-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung SD I Co., Ltd.; Park, In Kul; Kim, Hyung Mook; Park, Chae Won; Sin, Myung Yeop; Lee, Young Gi; Jung, Uii Soo; (31 pag.)KR2016/47824; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8Cl4N2

A reaction was performed at 270¡ã C. for 16 hours by following the procedure of Example 1 while using 80.0 g (0.301 mol) of 3,4,5,6-tetrachlorophthalonitrile in the place of pentachlorobenzonitrile and 0.1 g of sodium hydroxide in the place of potassium hydroxide. After the reaction was completed, the reaction solution was cooled to room temperature and then filtered to remove the suspended potassium chloride and the unaltered potassium fluoride. When the benzonitrile solution as the mother liquor was analyzed by gas chromatography, it was found to contain 55.4 g of 3,4,5,6-tetrafluorophthalonitrile and 0.018 g of benzoic acid fluoride (325 ppm based on the amount of 3,4,5,6-tetrafluorophthalonitrile). The stainless steel reaction vessel showed no discernible sign of corrosion.

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Shokubai Co., Ltd.; US6392084; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

0.60g (0.015 mol) of sodium hydroxide was added to a solution of 1.22g(0.0075 mol) of 3,5-dichloropyridin-4-amine in 40 mL of DMF, followed by addition of 2g (0.0075 mol) of 3,4,5,6-tetrachlorophthalonitrile under stirring, themixture was stirred for 5 h after addition at room temperature. After the reaction was over by Thin-Layer Chromatographymonitoring, the reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washedwith water and saturated brine, dried over anhydrous magnesium sulfate, filtered and then concentrated under reducedpressure. The residue was purified through silica column (ethyl acetate/petroleum ether (boiling point range 60-90¡ãC)= 1:4, as an eluent) to give 2.6 g of compound A-87 as yellow solid, m.p. 214-216¡ãC.[0070] 1H-NMR (300MHz, internal standard TMS, solvent DMSO), 8.26(s, 2H, Py-2,6-2H), 11.0(br, 1H, NH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1953-99-7, its application will become more common.

Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; LIU, Changling; HUANG, Guang; LAN, Jie; HAO, Shulin; LI, Zhinian; LI, Huichao; GUAN, Aiying; JIANG, Airu; XU, Ying; EP2757092; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 1953-99-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1953-99-7 name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Five grams of 3,4,5,6-tetrachlorophthalonitrile, 3.25 grams of 2-bromophenol, 3.9 grams of K2CO3, and 25 milliliters of N, N-dimethylformamide were placed in a 100 milliliter flask , Followed by stirring while heating at 70 ¡ãC. EIA (ethyl acetate) was used for extraction when the reaction was completed. After extraction, the resultant was concentrated to obtain a solid. In this context, the solid obtained is dissolved in a small amount of dichloromethane, washed several times with hexane, filtered and dried in vacuo to give 3,4,6-dichloro-5- (2-bromo-phenoxy ) -phthalonitrile.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Sanxing SDI Co., Ltd.; Zheng Yishu; Xu Huiyuan; Xin Mingye; Shen Xianxiong; Zheng Zhouhao; Han Guishi; (48 pag.)CN107522704; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1953-99-7, These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

100 mL flask Of Synthesis Example 1-2 4- (2-tert-Butyl-4-methoxy-phenoxy) -3,5,6-trichloro-phthalonitrile (1.1 g) 3,4,5,6-Tetrachlorophthalonitrile (0.71 g), 1,8-Diazabicycloundec-7-ene (1.02 g) And 1-pentanol (14 g) were added, and the mixture was heated at 90 ¡ã C to dissolve the solid. Then, zinc acetate (0.25 g) was added thereto and stirred while heating to 140 ¡ã C. After completion of the reaction, precipitation was confirmed with methanol, followed by filtration and vacuum drying. The dried solid is purified by column chromatography. Dichloromethane is appropriately added to the solid obtained after purification to dissolve the solid, and then methanol is added to crystallize. The crystallized solid is filtered and dried under vacuum to obtain a compound represented by the following general formula (10).

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Shin Myeong-yeop; Seo Hye-won; Jeong Ui-su; Han Gyu-seok; (41 pag.)KR2019/27185; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1953-99-7 name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis Example 4: Synthesis of 3,4,6-trichloro-5-(2,6-difluoro-phenoxy)-phthalonitrile 5 g of 3,4,5,6-tetrachlorophthalonitrile, 2.45 g of 2,6-difluorophenol, 3.9 g of K2CO3, and 25 ml of N,N-dimethyl formamide were put in s 100 ml flask, and then stirred while heated at 70¡ã C. When the reaction was complete, EA (ethyl acetate) was used for an extraction. After the extraction, the resultant was concentrated to obtain a solid. Herein, the obtained solid was dissolved in a small amount of dichloromethane, and then several times washed with hexane, filtered, and vacuum-dried to obtain 3,4,6-trichloro-5-(2,6-difluoro-phenoxy)-phthalonitrile.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JEONG, Euisoo; SEO, Hyewon; SHIN, Myoungyoup; SHIN, Sunwoong; JUNG, Juho; HAN, Gyuseok; (25 pag.)US2018/335547; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical industry reduces the impact on the environment during synthesis 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, I believe this compound will play a more active role in future production and life. 1953-99-7

Synthesis Example 1: Synthesis of 4-(biphenyl-2-yloxy)-3,5,6-trichloro-phthalonitrile 5 g of 3,4,5,6-tetrachlorophthalonitrile, 3.21 g of 2-phenylphenol, 3.9 g of K2CO3, and 25 ml of acetone were put in a 100 ml flask, and then stirred while heated at 70¡ã C. When the reaction was complete, the resultant was filtered and washed with acetone, and a liquid therefrom was distillated to obtain a solid. Herein, the obtained solid was dissolved in a small amount of dichloromethane, and then several times washed with hexane, filtered, and vacuum-dried to obtain 4-(biphenyl-2-yloxy)-3,5,6-trichloro-phthalonitrile.

The chemical industry reduces the impact on the environment during synthesis 1953-99-7. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JEONG, Euisoo; SEO, Hyewon; SHIN, Myoungyoup; SHIN, Sunwoong; JUNG, Juho; HAN, Gyuseok; (25 pag.)US2018/335547; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, A common compound: 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a 100 ml flask, 3,4,5,6-tetrachlorophthalonitrile (5 g), 2-phenylphenol (3.201 g), K2CO3 (3.898 g)And acetonitrile (50 ml), and reflux while heating. After completion of the reaction, the mixture was filtered, washed with tetrahydrofuran (THF)The resulting solid was dissolved in a small amount of dichloromethane and then hexane was added thereto to obtain a solid (4- (biphenyl-2-ylamino) -3,5,6-trichlorophthalonitrile). At this time, the obtained solid was washed several times, filtered and vacuum dried.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cheil Industries Co., Ltd.; Choe, Say Young; Kwon, JaeYoung; Park, Uhn B; Lee, Jong Son; Lee, Chang Ryul; Jong, Ju Ho; Choe, Mi Jin; Choe, Sung Gip; Hyung, Gyung Hee; (28 pag.)KR2015/130131; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1953-99-7.

[formula c] 0.0375 mol, [formula a]0.0125 mol, zinc bromide 0.015 mol and1,8- diazabicyclo [5.4.0] undec -7-ene 0.05 mol were added to amylalcohol 66 g and stirred. The reaction temperature was raised to 130 and the reaction was carried out for 8 hours. After thereaction was complete, the reaction solution was cooled down and concentratedunder reduced pressure to remove the solvent by 2/3. The addition of methanolwas followed by to crystalize the solution. The crystals were filtered underreduce pressure and was dispersedly filtered in the mixed solution of methanol50g for 1 hour. The crystals were suction filtered and vacuum dried at 60 to obtain phthalocyanine compound 7.9g.

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyung-In Synthetic Corporation; Park, Soon Hyeon; Kim, Jeong Ki; Kim, Jeong Rok; Lee, Yun Ah; Lee, Do kyeong; Lee, Min Jeong; Lee, Hui Jae; (16 pag.)KR2016/7024; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 3 was synthesized according to the reported procedure[27]. To the solution of tetrachlorophthalonitrile (1) (2 g,7.5 mmol) in anhydrous DMF (15 ml), 3-(diethylamino)phenol (2)(1.24 g, 7.5 mmol) was added. The reaction was allowed to stir for15 min, and finely powdered anhydrous Na2CO3 (1.59 g, 15 mmol)was added in portions to the reaction mixture over 1 h with efficientstirring. Then, the mixture was stirred at 30 C for 3 h. After3 h, the reaction was cooled to room temperature, poured into icecoldwater, extracted with ethyl acetate, washed with 1 M NaOHandwashed with a brine solution. The organic layerwas dried usingNa2SO4, and the solvents were evaporated to obtain the crudeproduct. The crude product was purified by column chromatographyusing hexane-ethyl acetate (90:10) as eluent. Yield (1.9 g65percent), 1H NMR (CDCl3, 300 MHz) d, 6.99 (t, J 8.4 Hz, 1H), 6.38 (dd,J 8.4 & 2.1 Hz, 1H), 6.22 (t, J 2.1 Hz, 1H), 5.68 (dd, J 7.8 & 1.5 Hz,1H), 3.26 (q, J 6.9 Hz, 4H) 1.10 (t, J 2.1 Hz, 6H) (Fig. S1), 13C NMR(CDCl3, 75 MHz) 155.9, 152.8, 148.6, 136.2, 135.3, 132.1, 129.2, 115.7,113.6, 110.8, 106.7, 99.1, 98.03, 43.4, 11.4 (Fig. S2). FT-IR (KBr pellet)(g, cm1) 2980 (AreCeH) 2920e2880 (Aliphatic-C-H), 2235 (C^N),1280 (CeOeC) (Fig. S3). LC-MS: m/z 396 [M2] (Fig. S4).

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Muthukumar, Palanisamy; Kim, Hak-Soo; Jeong, Jong Woo; Son, Young-A.; Journal of Molecular Structure; vol. 1119; (2016); p. 325 – 331;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts