Category: 1953-99-7

Synthetic Route of 1953-99-7,Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,4,5,6-tetrachlorophthalonitrile of 6 g (3 eq), KF of 1.8 g (3.1 eq), CaCO3 of 0.5 g (0.5 eq) and 1,2 ethanol of 2.5 g (4 eq) are put in acetone of about 30 ml to about 50 ml (30 eq), and reaction proceeds at room temperature overnight. When the completion of the reaction is verified by thin later chromatography (TLC), work-up is carried out. Subsequently, a resultant product is separated and purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its application will become more common.

Reference:
Patent; Samsung Display Co., Ltd.; Kim, Hyunjin; Kang, Sunwoo; Lee, Daewon; Huh, Chul; (14 pag.)US2016/327709; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis Example 1-Chloronaphthalene (500 parts) was added to tetrachlorophthalodinitrile (150 parts). After stirring the resultant mixture in a nitrogen atmosphere at room temperature for 30 minutes, boron trichloride (48 parts) was added. Subsequently, heating was conducted at a ramp rate of 1.6°C/min from room temperature to a temperature at which the formation of a subphthalocyanine began to take place (at that time, the reaction mixture turned into a violet color; the initiation temperature of the formation of the subphthalocyanine is 120°C to 130°C). The reaction mixture was heated further at the same ramp rate to 150°C, and at 150°C, was stirred under heating for 180 minutes. After allowed to cool down, the reaction mixture was introduced into methanol. The precipitate was collected by filtration, washed successively with water, acetone and toluene in this order, and then dried under heat in a vacuum (<1 mmHg, 180°C, 12 hr) to obtain a Cl-dodecachlorosubphthalocyanine boron complex represented by the below-described formula (143 parts, yield: 900). As a result of x-ray diffraction of the thus-obtained compound, strong diffraction peaks appeared around diffraction angles (2psi) of 6. 9°, 7.4°, 20.2°, 20.6°, 26.6° and 30.0° (FIG. 1). Further, its IR absorption spectrum presented at 880 cm-1 a strong absorption ascribable to a B-Cl bond. When measured by a high-performance liquid chromatograph ("MODEL 860-CO", manufactured by JASCO Corporation; column: "YMC-PACK PRO C18", manufactured by YMC Co., Ltd.; mobile phase: THF_water=80:20), the compound in which X was a chlorine atom was found to account for 100percent. The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings. Reference:
Patent; DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD.; Nippon Steel Chemical Co., Ltd.; EP1772494; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A reaction was performed and the reaction product was treated by following the procedure of Example 1 while omitting the addition of sodium hydroxide. When the benzonitrile solution as the mother liquor was similarly analyzed, it was found to contain 0.200 g of benzoic acid fluoride (3600 ppm based on the amount of 3,4,5,6-tetrafluorophthalonitrile). The stainless steel reaction vessel showed a sign of slight corrosion.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nippon Shokubai Co., Ltd.; US6392084; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8Cl4N2

5 g of 3,4,5,6-tetrachlorophthalonitrile, 2.45 g of 2,6-difluorophenol, 3.9 g of K2CO3 and 25 ml of N, N-dimethylformamide were stirred at 100 ml flask and then stirred while heating at 70 °C. When the reaction is complete, EA (ethyl acetate) is used for extraction. After extraction, the resultant was concentrated to obtain a solid. Here, the obtained solid is dissolved in a small amount of dichloromethane and then washed several times with hexane, filtered and dried in vacuo to give 3,4,6-trichloro-5- (2,6-difluoro -phenoxy) -phthalonitrile.

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanxing SDI Co., Ltd.; Zheng Yishu; Xu Huiyuan; Xin Mingye; Shen Xianxiong; Zheng Zhouhao; Han Guishi; (48 pag.)CN107522704; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 1953-99-7,Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 100 mL flask was added the solid (4- (biphenyl-2-ylamino) -3,5,6-trichlorophthalonitrile (1.0 g), 3,4,5,6-tetrachlorophthalonitrile (0.22 g), 1,8-Diazabicycloundec- -ene (1.0 g), and 1-pentanol (10 mL), and dissolve by heating. Then, zinc acetate (0.15 g) is added and refluxed with heating. After completion of the reaction, the solvent was removed, and the residue was purified by column chromatography. Dichloromethane is appropriately added to the obtained solid to dissolve the solid, and hexane is added to crystallize. At this time, the obtained solid is filtered and vacuum dried to obtain a compound represented by the following formula (C).

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co.,Co.,Ltd; Kwon, Jae Young; Jung, Ju Ho; Lee, Yeon Soo; Lee, Jung Sun; Lee, Chang Ryul; (35 pag.)KR2016/22080; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8Cl4N2

3,4,5,6-tetrachlorophthalonitrile (5 g), isoamyl alcohol (5.9 g), 1,8-diazabicycloundec-7-ene (3.898 g), and tetrahydrofuran (50 ml) are in a 100 ml flask and then stirred while heated at 50° C. When a reaction is complete, an extraction is performed with EA (ethyl acetate). After the extraction, a liquid column-purified through column chromatography with EA/hexane is concentrated to obtain a solid, and the solid is vacuum-dried, obtaining a compound according to Synthesis Example 4.

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd.; PAK, Chae Won; SEO, Hye Won; SHIN, Myoung Youp; JEONG, Eui Soo; CHOI, Seung Jib; (35 pag.)US2017/107224; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1953-99-7,Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example A 3,4,5,6-Tetrafluorophthalonitrile Anhydrous potassium fluoride (11.0 kg) is added to a 50 gallon stainless steel reactor. The salt is dried under 28 inches vacuum at 115°-138° C. for 48 hours. The salt is cooled to 100° C. and tetramethylenesulfone (19 liters) added followed by tetrachlorophthalonitrile (4.74 kg). The mixture is heated with stirring to 156° C. over a 30 minute period. Heating with vigorous agitation is continued for another 2.5 hours at 135°-162° C. The mixture was cooled to 31° C. (15 minutes) and ice (69 kg) and demineralized water (119 liters) were added. The resulting mixture was stirred 1.5 hours before centrifuging to collect crude product which was washed with demineralized water (120 liters). The crude product was transferred back into the 50 gallon stainless steel still and demineralized water (100 liters) added. The mixture was steam distilled until 80 liters of distillate were collected. The distillate was cooled to 0°-5° C. and the product collected on a centrifuge. The crystals were washed with demineralized water (2*90 liters) to give 2.82 kg wet product: LOD 6.4percent; calculated yield: 74percent. A small sample was dried under vacuum for two days at room temperature; mp 81°-83° C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its application will become more common.

Reference:
Patent; Warner-Lambert Company; US4782180; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1953-99-7,Some common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Five grams of 3,4,5,6-tetrachlorophthalonitrile, 3.06 grams of 2,6-dichlorophenol, 3.9 grams of K2CO3, and 25 milliliters of acetone were placed in a 100-milliliter flask and then Stir while heating at 70 °C. When the reaction was completed, the resultant was filtered and washed with acetone, and the resulting liquid was distilled to obtain a solid. Here, the obtained solid was dissolved in a small amount of dichloromethane and then washed with hexane several times, filtered and dried under vacuum to obtain 3,4,6-dichloro-5- (2,6-bis Chloro-phenoxy) -phthalonitrile.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its application will become more common.

Reference of 1953-99-7, These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(i) Preparation of 1,2-dicyano-3,4,5,6-tetraphenoxybenzene A mixture of 1,2-dicyano-3,4,5,6-tetrachlorobenzene (50 parts), phenol (106 parts), potassium carbonate (104 parts) and dimethylformamide (200 parts) was stirred and heated at 70¡ã C. for 2 hours before pouring into water (500 parts). The aqueous mixture was extracted with chloroform (2*300 parts). The chloroform extract was washed with a 5percent aqueous solution of sodium hydroxide (2*250 parts) and then with water (2*250 parts). The chloroform extract was dried over anhydrous magnesium sulphate, filtered and the chloroform was removed by distillation under reduced pressure to leave a brown oil. The brown oil was dissolved in hot butan-1-ol and allowed to cool slowly. 1,2-Dicyano-3,4,5,6-tetraphenoxybenzene (62.2 parts, 67percent) was obtained as a pale yellow solid m.p. 149¡ã-151¡ã C.

Statistics shows that 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile is playing an increasingly important role. we look forward to future research findings about 1953-99-7.

Reference:
Patent; Zeneca, Limited; US5486274; (1996); A;; ; Patent; Zeneca Limited; US5484915; (1996); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 100 mL flask was added the solid (4- (biphenyl-2-ylamino) -3,5,6-trichlorophthalonitrile) (1.0 g), 3,4,5,6-Tetrachlorophthalonitrile (0.67 g), 1,8-Diazabicycloundec-7-ene (1.5 g) and 1-pentanol (15 mL). Thereafter, zinc acetate (0.23 g) is added and refluxed with heating. After completion of the reaction, the solvent was removed,Purify by chromatography. Dichloromethane was appropriately added to the obtained solid to dissolve the solid, and hexane was added to obtain crystals. At this time, the obtained solid was filtered and dried under vacuum to obtain a compound represented by the following general formula (8).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, other downstream synthetic routes, hurry up and to see.