Category: 1953-99-7

Adding a certain compound to certain chemical reactions, such as: 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1953-99-7, Application In Synthesis of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

To a boiling solution of lithium 1-hexanolate in 1-hexanol, prepared via dissolving 0.1 g oflithium in 20 ml of anhydrous 1-hexanol, added compound 3 (0.7 g, 2 mmol) and compound5 (0.53, 2 mmol). After 5 h, the reaction mixture was cooled and mixed with 50 ml of acetoneand 5 ml of acetic acid. Then reaction mixture was concentrated at rota evaporator, purifiedby silica gel column chromatography usingDCM:CH3OH(20:1) as an eluent to obtain an oilybluish green compound as a major fraction, To this compound Zn(OAc)2·2H2O (0.13 g, 0.6mmol), and 20 ml of DMF added and heated at reflux for 1 h. After cooling, to the reactionmixturewas added 100ml of water and 100ml of chloroform. The organic layer was separated,washed with 100ml of water, then reaction mixture was concentrated at rota evaporator, purifiedby silica gel column chromatography using DCM:CH3OH (20:1) as an eluent to obtainoily bluish green compound 6 (0.368 g, 52.5percent). IR (KBr tablet) numax/cm?1: 3018, 2956, 2857,1597, 1492, 1265, 1214, 1154, 1092, 971, 745. 54H18Cl8F6N84Zn; Calculated, percent: 49.67; H1.39; N 8.58; O 4.9, Found, percent: 49.89; H 1.42; N 8.48; O 4.93. UV-Vis: nm (log epsilon): in CHCl3;660(102),715(142),815(45). MALDI-TOF-MS: m/z calcd for 54H18Cl8F6N84Zn, 1303.81;found 1304.74 [M + H+]+.

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Reference:
Article; Jeong, Jaemyeng; Kumar, Rangaraju Satish; Kim, Ick Jin; Son, Young-A; Molecular Crystals and Liquid Crystals; vol. 644; 1; (2017); p. 249 – 256;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1953-99-7, These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 ml flask, 3,4,5,6-tetrachlorophthalonitrile (5 g), 2,6-dichlorophenol (2.45 g), K2CO3 (3.9 g) and N,N-dimethylformamide And the mixture was stirred while heating to 70°C. After completion of the reaction, the reaction mixture is extracted with EA (ethyl acetate). After extraction and concentration, a solid can be obtained. The resulting solid is dissolved in a small amount of dichloromethane, washed several times with hexane, filtered, and vacuum dried to obtain 3,4,6-trichloro-5-(2,6-dichloro-phenoxy)-phthalonitrile.

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Seo Hye-won; Shin Myeong-yeop; Jeong Ui-su; Han Gyu-seok; (56 pag.)KR2019/11995; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1953-99-7, A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,4,5,6- tetrachloro phthalo nitrile 0.1 mol anddiethylmalonate 0.1 mol, and potassium carbonate 0.1 mol were stirred withdimethylformamide 60 g at 60 for3~4 hours. Afterthe reaction was complete, the reaction solution was cooled down atroom temperature. The reaction solution was added to water 250 g to crystallizeitself. Thecrystals were filtered under reduce pressure and were dispersedly filtered inthe mixed solution of methanol 50g and water 50g for 1 hour. The crystals were suction filteredand vacuum dried at 60 toobtain [formulaf] compound 30g.

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyung-In Synthetic Corporation; Park, Soon Hyeon; Kim, Jeong Ki; Kim, Jeong Rok; Lee, Yun Ah; Lee, Do kyeong; Lee, Min Jeong; Lee, Hui Jae; (16 pag.)KR2016/7024; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8Cl4N2

In a 100 ml flask, 3,4,5,6-tetrachlorophthalonitrile (5 g), 2,4-dimethylphenol (2.75 g), K2CO3 (3.9 g), N, N-dimethylformamide (N, N-dimethylformamide) (25 ml) And the mixture was stirred while heating to 70 ° C. After completion of the reaction, the reaction mixture is extracted with EA (ethyl acetate). After extraction and concentration, a solid can be obtained. The resulting solid was dissolved in a small amount of dichloromethane, Washed several times with hexane, After filtration and vacuum drying, 3,4,6-Trichloro-5- (2,4-dimethylphenoxy) phthalonitrile is obtained.

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Shin Myeong-yeop; Seo Hye-won; Jeong Ui-su; Han Gyu-seok; (41 pag.)KR2019/27185; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, A new synthetic method of this compound is introduced below., name: 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

To a 100 mL flask2,4-Bis (alpha,alpha -dimethylbenzyl) -2-yloxy) -3,5,6-trichloro-phthalonitrile (1 g), 3,4,5,6-Tetrachlorophthalonitrile 1,8-Diazabicycloundec-7-ene (0.8 g), 1-pentanol (7 g) and zinc acetate (0.2 g) were added and stirred while heating to 140 ° C. After completion of the reaction, the mixture is concentrated and purified by column chromatography.The liquid obtained after purification is concentrated to obtain a solid. The crystallized solid is vacuum-dried to obtain a compound represented by the following formula (6).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Samsung SDI Co., Ltd; Jeong Ui-su; Seo Hye-won; Shin Myeong-yeop; Han Gyu-seok; (40 pag.)KR2019/13136; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1953-99-7, A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(i) Preparation of 1,2-dicyano-3,4,5,6-tetra(2-naphthoxy)benzene 1,2-Dicyano-3,4,5,6-tetrachlorobenzene (30.5 parts), potassium carbonate (62.8 parts) and 2-naphthol (98.1 parts) were stirred in dimethylformamide (140 parts) at 70 C. for 3 hours. The mixture was poured into water (300 parts) and extracted with chloroform (3*300 parts). The combined chloroform extracts were washed with dilute aqueous sodium hydroxide solution (500 parts) and then with water (500 parts). The chloroform was dried over anhydrous magnesium sulphate before evaporating under reduced pressure to leave a brown liquid which crystallized on adding butan-1-ol, cooling and standing for 2 hours. The crystallized solid was filtered, washed with butan-1-ol until the filtrates were colourless. The solid was dried to give 1,2-dicyano-3,4,5,6-tetra(2-naphthoxy)benzene (40.6 parts), m.p. 188-190 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zeneca, Limited; US5486274; (1996); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

To a 100 mL flask4-Bis (?,? – dimethylbenzyl) -2-yloxy) -3,5,6-trichloro-phthalonitrile (0.5 g), 3,4,5,6-Tetrachlorophthalonitrile (0.85 g), 1,8-Diazabicycloundec-7-ene (0.7 g),1-pentanol (7 g) and zinc acetate (0.4 g) were added and stirred while heating to 140 ° C. After completion of the reaction, the mixture is concentrated and purified by column chromatography. The liquid obtained after purification is concentrated to obtain a solid. The crystallized solid was vacuum-dried to obtain a compound represented by the following formula (C-3).

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Jeong Ui-su; Seo Hye-won; Shin Myeong-yeop; Han Gyu-seok; (40 pag.)KR2019/13136; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

Synthesis Example 3: Synthesis of 3,4,6-trichloro-5-(2,6-dibromo-phenoxy)-phthalonitrile 5 g of 3,4,5,6-tetrachlorophthalonitrile, 4.75 g of 2,6-dibromophenol, 3.9 g of K2CO3, and 25 ml of N,N-dimethyl formamide were put in a 100 ml flask and stirred while heated at 70° C. When the reaction was complete, EA (ethyl acetate) was used for an extraction. After the extraction, the resultant was concentrated to obtain a solid. The obtained solid was dissolved in a small amount of dichloromethane, several times washed with hexane, filtered, and vacuum-dried to obtain 3,4,6-trichloro-5-(2,6-dibromo-phenoxy)-phthalonitrile.

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JEONG, Euisoo; SEO, Hyewon; SHIN, Myoungyoup; SHIN, Sunwoong; JUNG, Juho; HAN, Gyuseok; (25 pag.)US2018/335547; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1953-99-7

3,4,5,6-tetrachlorophthalonitrile (5 g), 2-phenylphenol (3.21 g), K2CO3 (3.9 g) and acetone (25 ml) were placed in a 100 ml flask and stirred while heating to 70 ° C. After completion of the reaction, the solid matter is obtained by filtering and distilling off the liquid obtained by washing with acetone. At this time, the obtained solid is dissolved in a small amount of dichloromethane, washed with nucleic acid several times, filtered and vacuum dried to obtain 4-(biphenyl-2-yloxy)-3,5,6-trichloro-phthalonitrile

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Seo Hye-won; Shin Myeong-yeop; Jeong Ui-su; Han Gyu-seok; (56 pag.)KR2019/11995; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

As it is shown in Scheme 3 above, 3,4,5,6-tetra-chloride in a nitrogen gas rope phthaloyl nitrile (tetrachlorophthalonitrile) (5.0mmol), 2,5- di (di) – [tert (tert) – butyl (butyl ) -4-methoxyphenol (methoxyphenol) (1.5 eq.), potassium carbonate (K 2 CO 3) (10 equivalents) of anhydrous (anhydrous) dissolved in 30ml DMF after 12 hours at 80 dongan reflux (reflux) thereby.After completion of reaction, the reaction solution into ice water slowly degrades (ice water) (dropwise). Then, methylene chloride: then extracted three times, magnesium sulfate (MgSO with (methylene chloride MC) 4 is removed by passing the water in) and evaporated (evaporation).Then, the obtained phthalonitrile (phthalonitrile) precursor to the dried crude product (crude product) was purified by column chromatography (column chromatography).

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Display Co., Ltd; Seoul National University Industry-Academic Cooperation Foundation; Kim, Young Hun; Ahn, Byung Gun; Han, Sang Hun; Kim, Jae Pil; Choe, Jun; Namgung, Jinung; (13 pag.)KR2016/5258; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts