Category: 1897-52-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1897-52-5, name is 2,6-Difluorobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H3F2N

To a suspension of 2,6-difluorobenzonitrile (20.0 g, 144 mmol) andK2CO3 (40.00 g, 289 mmol) in dimethyl sulfoxide (80 mL), morpholine(13.20 g, 152 mmol) was slowly added. The mixture was heated at 90 C for 3 h. After completion of the reaction, as indicated by TLC,the reaction mixture was carefully poured into stirred water (500 mL)and then filtered. The filter cake was washed with water and dried to yield 18.0 g of 2-fluoro-6-morpholinobenzonitrile in 90.0% yield;m.p. 69-70 C (lit.13 69-70 C); IR (KBr, numax/cm-1): 3096, 2972, 2950,2879, 2869, 2226 (CN), 1605, 1567, 1447, 1257, 1230, 1114, 1082, 1058;MS (ESI) m/z (%): 207.3 [M+H]+; Anal. calcd for C11H11FN2O: C,64.07; H, 5.38; N, 13.58; found: C, 63.99; H, 5.42; N, 13.63%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ji, Xiao-Hui; Jin, Ling-Xia; Zhao, Cai-Bin; Zheng, Nan; Song, Juan; Ge, Hong-Guang; Liu, Quan; Lu, Jiu-Fu; Journal of Chemical Research; vol. 42; 10; (2018); p. 504 – 507;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1897-52-5, Adding some certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5.

Example 94; 5-[1-(2-Trifluoromethylphenyl)-ethoxy]-quinazoline-2,4-diamine; [00287] Step 1; A solution of alpha-methyl-2- (trifluoromethyl)benzyl (750 mg; 3.9 mmol) in dimethylformamide was added to a cooled (0 C) slurry of sodium hydride (156 mg; 3.9 mmol) in dimethylformamide under nitrogen atmosphere. The reaction mixture was slowly warmed to room temperature, and stirred for 45 minutes. In another vessel, a solution of 2,6-difluorobenzonitrile (543 mg, 3.9 mmol) in dimethylfomamide was chilled to 0 C, and activiated anion was added over 20 minutes. Mixture was then stirred 2 hours at room temperature. The reaction mixture was poured on crushed ice-water, stirred, filtered, washed with water and dried to afford 1.2 g of solid (99% yield) of 2-fluoro-6-[1-(2-trifluoromethylphenyl)-ethoxy]- benzonitrile.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1897-52-5.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts