Category: 1897-52-5

Application of 1897-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1897-52-5, name is 2,6-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a piperidine (5 mL, 50.6 mmol) solution in toluene (20 mL) was added MeMgCI (3.0 M in THF, 16.9 mL, 50.6 mmol). The solution was heated to 50 C, for two hours before allowing to cool to room temperature and transferring using a cannula to a solution of 2,6-difluorobenzonitrile (7.03 g, 50.6 mmol) in toluene (20 mL). The solution was stirred for 16 h at room temperature after which time the reaction was quenched by addition of water (1 mL). After stirring for an hour, anhydrous sodium sulfate was added and the solution was then filtered to remove salts. The clear solution was then washed with brine (2 x 40 mL) before removal of the volatiles under reduced pressure to yield a viscous yellow oil. This was then diluted with another portion of hexanes (15 mL) and placed at -20 C for two days resulting in crystallization of the desired product. Yield = 8.7 g (77 %). 1H NMR (300 MHz) (CDCb) delta (ppm): 7.24 (m, 1 H, Ar); 6.86 (m, 2 H, Ar); 6.06 (m, 1 H, NH), 3.33 (br m, 4 H, NCH2), 1.53 (br m, 6 H, CH2CH2CH2) ppm. 19F- NMR (282 MHz, CDCI3) delta: -1 13.30 ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LANXESS ELASTOMERS B.V.; KARBAUM, Peter; SCOTT, Richard, Thomas, William; VAN DE MOOSDIJK, John; (39 pag.)WO2016/41818; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1897-52-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1897-52-5 as follows.

To the suspension of 2,6-difluorobenzonitrile (20.0 g, 144 mmol), K2CO3 (40.00 g, 289 mmol) in dimethyl sulfoxide (80 mL), morpholine (13.20 g, 152 mmol) was added slowly. The mixture was heated at 90C for 3 hours. After completion of the reaction as indicated by TLC, the reaction mixture was carefully poured into stirring water (500 mL), then filtered. The filter cake was washed with water and dried to afford 18.00 g of 2-fluoro-6-morpholinobenzonitrile: Yield 90.0%; m.p. 69-70 C; IR (numax,cm-1) KBr: 3096 (Ar), 2869 (CH2), 2226 (CN), 1605 (Ar), 1567 (Ar), 1082 (O); 1H NMR (600 MHz, CDCl3) delta 7.42-7.50 (m, 1H), 6.73-6.80 (m, 2H), 3.87 (m, 4H), 3.24 (m, 4H); MS(ESI) m/z: 207.3 [M + H]+; Anal. calcd for C11H11FN2O: C, 64.07; H,5.38; N, 13.58; found: C, 63.99; H, 5.42; N, 13.63%.

According to the analysis of related databases, 1897-52-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lu, Jiu-fu; Zhou, Xing-long; Xu, Yu-hang; Yue, Si-yu; Ji, Xiao-hui; Zheng, Nan; Jin, Ling-xia; Journal of Chemical Research; vol. 41; 9; (2017); p. 526 – 528;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H3F2N

Take a 500mL eggplant bottle,20.0 g of 2,6-difluorobenzonitrile was added,Anhydrous potassium carbonate 40.0 g and dimethyl sulfoxide 200 mL,Warming up to 90 C,Slowly drip morpholine 13.20g with stirring.TLC detects the progress of the reaction,After the reaction is completed, the reaction solution is naturally cooled to room temperature.Pour into the stirring ice water solution,18.0 g of white solid powder was precipitated.That is, 2-fluoro-6-morpholinylbenzonitrile (a).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1897-52-5, its application will become more common.

Reference:
Patent; Liaoning University; Liu Ju; Chen Ye; Gong Yilin; Wang Yang; Ding Shi; Shi Jiantao; Cao Shuwen; (12 pag.)CN108558763; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1897-52-5,Some common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,6-Difluorobenzonitrile (2.78 g, 20.0 mmol) and 3-(trifluoromethyl)phenol (3.89 g, 24.0 mmol) were dissolved in DMF(20 mL) and K2CO3 (8.29 g, 60 mmol) was then addedand the resulting mixture was heated at 100C for 16 h.After cooling to room temperature, the mixture was subjectedto EtOAc:water extraction and the organic layer wasthen separated, washed with 1 N NaOH and then with 10%aqueous K2CO3, dried (MgSO4), and evaporated to get2-fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile (5.23 g,93% yield).

The synthetic route of 1897-52-5 has been constantly updated, and we look forward to future research findings.

Reference:
Note; Bepary, Sukumar; Yoon, In Kwon; Lee, Ge Hyeong; Bulletin of the Korean Chemical Society; vol. 37; 12; (2016); p. 2054 – 2057;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1897-52-5 as follows. HPLC of Formula: C7H3F2N

20.0 g of 2,6-difluorobenzonitrile, anhydrous potassium carbonate 20.0 g and dimethyl sulfoxide 100 mL, add to the reaction flask, stir evenly, and warm to 90 C. Slowly drip morpholine 6.60g with stirring. Keep the temperature at 90 C for 3 hours. The reaction solution was naturally cooled to room temperature and poured into an appropriate amount of ice water. Precipitating a white solid powder, filtering, the filter cake was washed with water and dried to obtain 9.0 g of a product. That is, 2-fluoro-6-morpholinylbenzonitrile (1).

According to the analysis of related databases, 1897-52-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanxi University Of Science And Technology; Lu Jiufu; Jin Lingxia; Yu Xiaohu; Zhao Caibin; Zhou Ke; Song Juan; (7 pag.)CN109879827; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5, Recommanded Product: 2,6-Difluorobenzonitrile

58. Preparation of 3-Amino-4-fluoro-1-methylindazole Methylhydrazine (4.96 g, 108mmol was added to a solution of 15.0 g (108 mmol) of 2,6-difluorobenzonitrile in 150 mL of ethanol and the mixture was heated to reflux with stirring for 72 hours. The volatiles were then removed by evaporation under reduced pressure and the residue was dissolved in dichloromethane. The resulting solution was washed with water, dried over magnesium sulfate, and evaporated to dryness under reduced pressure to obtain the title compound as a white solid. This was recrystallized from ethanol to obtain 10.1 g (57 percent of theory) of the title compound as white crystals melting at 125-127 C. Elemental Analysis C8 H8 FN3 Calc.: %C, 58.2; %H, 4.88; %N, 25.4 Found: %C, 58.7; %H, 4.76; %N, 25.9 1 H NMR CDCl3: 7.19 (m, 1H), 7.11 (d, 1H, J=8.4), 6.59 (d of d, 1H, J=8.4, 3.3), 5.26 (brs, 2H), 3.72 (s, 3H); 13 C NMR CDCl3: 157.35, 154.88, 146.20, 146.18, 143.85, 143.76, 127.62, 127.55, 105.31, 105.27, 103.44, 103.24, 101.96, 101.78, 34.74.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; DowElanco; US5571775; (1996); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1897-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1897-52-5, name is 2,6-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 1 2-Amino-6-fluoro-benzonitrile 50 parts of 2,6-difluorobenzonitrile and 40 parts by volume of ammonia are stirred for 10 hours at 100 C. in a closed vessel. The reaction mixture is taken up in methylene chloride, the solid is filtered off, the organic phase is extracted three times by shaking with water and is dried over sodium sulfate, the solvent is stripped off and the residue is dried under reduced pressure. 48 parts (98.1% of theory) of 2-amino-6-fluoro-benzonitrile, of solidification point 125-128 C., are obtained.

The synthetic route of 2,6-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF Aktiengesellschaft; US4359428; (1982); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1897-52-5 as follows. COA of Formula: C7H3F2N

4.00 g (35.65 mmol) of potassium tert-butoxide and 2.60 g (34.64 mmol) of acetohydroxamic acid are dissolved in 50 ml of dry dimethylformamide and stirred at room temperature for 45 minutes. After the addition of 3.30 g (23.72 mmol) of 2,6-difluorobenzonitrile, the mixture is stirred at 50 C. for 16 hours. The mixture is concentrated under reduced pressure, and the residue is dissolved in dichloromethane and washed with water. After drying and concentration of the organic phase, 3.2 g of a yellow resin are obtained, which, according to 1H NMR, is about 85% pure

According to the analysis of related databases, 1897-52-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER CROPSCIENCE AG; US2010/267703; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5, Formula: C7H3F2N

General procedure: To an oven dried round bottom flask charged with a mixture of 2-fluorobenzonitrile (1a, 1 mmol) and hydrazine (2a, 1mmol) in ethanol (3 ml), stirred the reaction mixture at 80 C, for 30 min. To the reaction mixture isatin (3a, 1 mmol), 5,5-dimethyl-1,3-cyclohexanedione (4a, 1 mmol) and p-TSA (40 mol %) was added and the reaction mixture was further stirred at 80 C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, solid products was filtered under vacuum, air dried, to obtain the analytically pure products. The compounds 5a-5r were also synthesized by adopting this procedure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Balwe, Sandip Gangadhar; Lim, Kwon Taek; Cho, Byung Gwon; Jeong, Yeon Tae; Synthetic Communications; vol. 49; 4; (2019); p. 602 – 610;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5, Safety of 2,6-Difluorobenzonitrile

Cyano-(2-cyano-3-fluoro-phenyl)-acetic acid ethyl ester. A mixture of cyanoacetic acid ethyl ester (26.7 mL, 251 mmol), 2,6- difiuorobenzonitrile (33.2 g, 239 mmol) and potassium carbonate (82.5 g, 597 mmol) in dimethyl sulfoxide (120 mL) was stirred at +55C for 16 hours and poured into ice- water mixture (ca. 400 mL). It was acidified with cone. aq. HCl with caution (CO2 evolution) and extracted with ethyl acetate (600 ml). The organic phase was washed with brine (100 mL) and evaporated to give 55.1 g of a pale yellow solid that was used in the next step without further purification. 1H NMR (500 MHz, CDCl3): 1.35 (t, J=7.0 Hz, 3H), 4.34 (m, 2H), 5.13 (s, IH), 7.33 (t, J=8.4 Hz, IH), 7.57 (d, J=7.9 Hz, IH), 7.33 (dd, J=7.9 Hz, J=13.9 Hz, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Difluorobenzonitrile, and friends who are interested can also refer to it.