Related Products of 1897-43-4, These common heterocyclic compound, 1897-43-4, name is 2,5-Dichloroterephthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen atmosphere, 15.4 g of the intermediate (A), 6.64 g of 2,5-dichloroterephthalonitrile, 10.2 g of potassium carbonate, 112 mL of N-methyl-2-pyrrolidinone were put into a flask and stirred at 100 degrees C. for six hours and subsequently at 150 degrees C. for nine hours. After cooled down to the room temperature, the reaction solution was extracted with toluene. After an aqueous layer was removed, an organic layer was washed with a saturated ammonium chloride aqueous solution. After dried with magnesium sulfate, the organic layer was concentrated. The obtained residue was refined by silica-gel column chromatography, whereby 5.27 g (yield 28%) of a yellow solid of a compound 1 was obtained. It should be noted that N-methyl-2-pyrrolidinone is occasionally abbreviated as NMP.
Statistics shows that 2,5-Dichloroterephthalonitrile is playing an increasingly important role. we look forward to future research findings about 1897-43-4.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; TASAKI, Satomi; KAWAMURA, Masahiro; OGIWARA, Toshinari; KUMA, Hitoshi; YOSHIDA, Kei; OKINAKA, Keiji; (240 pag.)US2016/130225; (2016); A1;,
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