Category: 1885-38-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1885-38-7, name is (E)-Cinnamonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C9H7N

General procedure: Cu(NO3)2·3H2O (0.10 mmol), the appropriate nitrile 1 (1.0 mmol), NaN3(2.0 mmol) and DMF (1 mL) were added to a 50 mL round-bottomed flask equipped with a magnetic stirrer. The reaction mixture was stirred in an oil bath at 120 C for 16 h. After cooling to room temperature, the reaction was acidified HCl (3 M, pH 1.0). Ethyl acetate (~30 mL) wasadded, and stirring was continued until no solid was present. The organic layer was separated, and the aqueous layer was extracted with ethylacetate twice. The combined organic layers were washed with saturatedbrine, and concentrated in vacuo. The residue was purified by columnchromatography (silica gel, EtOAc-PE) to afford the product 2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Tao, Chuanzhou; Wang, Bin; Sun, Lei; Yi, Jiuyin; Shi, Dahua; Wang, Jian; Liu, Weiwei; Journal of Chemical Research; vol. 41; 1; (2017); p. 25 – 29;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1885-38-7, The chemical industry reduces the impact on the environment during synthesis 1885-38-7, name is (E)-Cinnamonitrile, I believe this compound will play a more active role in future production and life.

General procedure: Under a nitrogen atmosphere, a mixture of [RhCl(C2H4)2]2 (1.8 mg,0.0045 mmol) and ligand L1f (3.7 mg, 0.0099 mmol) in toluene(1 mL) was stirred at r.t. for 15 min, at which time arylboronic acid(0.60 mmol) was added, followed by cyanoalkenes (0.30 mmol),aqueous KOH (0.75 M in H2O, 0.20 mL, 0.15 mmol) and toluene(1 mL). The reaction was stirred at 80 C for 12 h, after which thereaction mixture was concentrated in vacuo and purified by silica gelflash column chromatography (petroleum ether/ethyl acetate as eluent)to give the product

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Cinnamonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Xue, Feng; Zhu, Yong; Qi, Xiaolei; Journal of Chemical Research; vol. 42; 6; (2018); p. 300 – 304;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 1885-38-7, A common heterocyclic compound, 1885-38-7, name is (E)-Cinnamonitrile, molecular formula is C9H7N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical reaction, 0.015 g of catalyst and 2 mmol of the reactant were taken in 10 mL of ethanol under hydrogen atmosphere. The reaction was monitored by thin-layer chromatography (TLC). After complete disappearance of the starting material, the catalyst was separated by simple filtration and the solvent was removed under reduced pressure to obtain the pure product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Lakshmi, Kantam M.; Parsharamulu; Manorama; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 115 – 119;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 1885-38-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1885-38-7 name is (E)-Cinnamonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a Schlenck flask filled with gaseous carbon dioxide, to a stirred THF (1.5 mL) solution of the alpha,beta-unsaturated compound 1 (0.25 mmol) and bis(acetylacetonato)cobalt(II) (conditions A: 3.2 mg, 5 mol %; conditions B: 6.4 mg, 10 mol %) was added a 1.0 M n-hexane solution of diethylzinc (conditions A: 0.5 mL, 2 equiv; conditions B: 1.0 mL, 4 equiv) at 0 C, then the reaction mixture was stirred at 20 C for 1-48 h. After checking the completed reaction by TLC analysis, the reaction mixture was quenched with a 1.0M hydrochloric acid diethyl ether solution (conditions A: 1.5 mL, 6 equiv; conditions B: 3.0 mL, 12 equiv) at 0 C. The organic layer was extracted with diethyl ether, washed with brine, dried over sodium sulfate and concentrated in vacuum. The residue was purified by silica gel column chromatography (Hexanes:AcOEt:HCOOH = 1:1:0.003) to afford the desired carboxylic acid 2. The resulting compound was diluted with a mixed solution (6.25 mL, diethyl ether:MeOH = 5:1) and methylated with trimethylsilyldiazomethane in n-hexane (ca. 0.6M solution, (1.04 mL, 2.5 equiv)). After purification by chromatography on silica gel, the corresponding methyl carboxylate was isolated.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Cinnamonitrile, and friends who are interested can also refer to it.

Reference:
Article; Hayashi, Chika; Hayashi, Takuo; Yamada, Tohru; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 862 – 870;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H7N

In accordance with Scheme la, hydrogen chloride is bubbled through a solution ofcinnamonitrile 1 in methanol at room temperature. The volatiles are removed under reduced pressureand the resulting residue is triturated with ether and filtered to yield the intermediate imidate 2. Imidate2 is dissolved in methanol at ambient temperature, treated with amine 4 (commercially available fromAcros Chemicals) at ambient temperature and stirred under argon. The volatiles are removed underreduced pressure and the residue purified by preparative HPLC or trituration with ether to afford amidine3.

The synthetic route of 1885-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2004/108705; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Similarly to the above-described, using sodium borohydride (0.4 g, 0.011 mol), 20 mL of isopropanol, anhydrous nickel(II) chloride (0.7 g, 0.006 mol), and cinnamic acid nitrile (6 g, 0.046 mol). The reaction duration was 6 h, the temperature was 70C. 3-Phenylpropionitrile 6e, content 48.9 wt %. Mass spectrum, m/e (Irel, %): 132.0 (10) [M+1], 130.7 (12) [M]+,129.0 (2), 104.0 (2), 91.1 (100), 65.0 (14). Starting cinnamic acid nitrile was also detected in the reaction mixture, its content was of 47.9 wt %.

The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mokhov; Popov; Shcherbakova; Russian Journal of General Chemistry; vol. 86; 2; (2016); p. 273 – 280; Zh. Obshch. Khim.; vol. 86; 2; (2016); p. 245 – 252,8;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1885-38-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1885-38-7, name is (E)-Cinnamonitrile, A new synthetic method of this compound is introduced below.

General procedure: Under a nitrogen atmosphere, a mixture of [RhCl(C2H4)2]2 (1.8 mg,0.0045 mmol) and ligand L1f (3.7 mg, 0.0099 mmol) in toluene(1 mL) was stirred at r.t. for 15 min, at which time arylboronic acid(0.60 mmol) was added, followed by cyanoalkenes (0.30 mmol),aqueous KOH (0.75 M in H2O, 0.20 mL, 0.15 mmol) and toluene(1 mL). The reaction was stirred at 80 C for 12 h, after which thereaction mixture was concentrated in vacuo and purified by silica gelflash column chromatography (petroleum ether/ethyl acetate as eluent)to give the product

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Xue, Feng; Zhu, Yong; Qi, Xiaolei; Journal of Chemical Research; vol. 42; 6; (2018); p. 300 – 304;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts