Sep-21 News Extended knowledge of 1885-38-7

The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.

Reference of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of cinnamonitrile (2.5 g, 19.38 mmol) in MeOH (50 mL) was added Br2 (6.2 g, 38.76 mmol) dropwise at 0oC. Then the reaction mixture was warmed to room temperature and stirred overnight. The resulting mixture was poured into water (50 mL) and basified with solid NaHCO3. The resulting mixture was extracted with EtOAc (3*50 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by CC on silica gel eluting with PE : EA =10:1 to PE : EA =4:1 to give 2,3-dibromo-3- phenylpropanenitrile (3.2 g) as a oil. (yield, 57.7 %). LC/MS (ESI, m/z): [M+1]+ = 290.1.

The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KYMERA THERAPEUTICS, INC.; MAINOLFI, Nello; JI, Nan; KLUGE, Arthur F.; (282 pag.)WO2019/140387; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

September 28, 2021 News Discovery of 1885-38-7

The synthetic route of 1885-38-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks

In accordance with Scheme la, hydrogen chloride is bubbled through a solution ofcinnamonitrile 1 in methanol at room temperature. The volatiles are removed under reduced pressureand the resulting residue is triturated with ether and filtered to yield the intermediate imidate 2. Imidate2 is dissolved in methanol at ambient temperature, treated with amine 4 (commercially available fromAcros Chemicals) at ambient temperature and stirred under argon. The volatiles are removed underreduced pressure and the residue purified by preparative HPLC or trituration with ether to afford amidine3.

The synthetic route of 1885-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2004/108705; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

S-21 News Discovery of 1885-38-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Cinnamonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(b) (2E)-3-Phenyl-2-propenimidamide; Cinnanionitrile (25.0 g, 194 mmol) was dissolved in EtOH. The solution was cooled to 0 0C and HCl gas bubbled through the solution for 30 minutes. The solution was stirred at ambient temperature for 1 h and then concentrated under vacuum. The residue was dissolved in EtOH (100 niL), cooled to 00C and a solution of NH3/Me0H (7M, 69 mL, 484 mmol) was added dropwise through an addition funnel. Once added, the solution was allowed to warm to ambient temperature and stirred overnight and the resulting NH4Cl was filtered off. The solution was concentrated under vacuum and the resulting product was used without further purification (28.6 g crude). LC-MS: m/z 147.4 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Cinnamonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/3690; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

9/15/2021 News Some tips on 1885-38-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1885-38-7, name is (E)-Cinnamonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H7N

General procedure: Cu(NO3)2·3H2O (0.10 mmol), the appropriate nitrile 1 (1.0 mmol), NaN3(2.0 mmol) and DMF (1 mL) were added to a 50 mL round-bottomed flask equipped with a magnetic stirrer. The reaction mixture was stirred in an oil bath at 120 C for 16 h. After cooling to room temperature, the reaction was acidified HCl (3 M, pH 1.0). Ethyl acetate (~30 mL) wasadded, and stirring was continued until no solid was present. The organic layer was separated, and the aqueous layer was extracted with ethylacetate twice. The combined organic layers were washed with saturatedbrine, and concentrated in vacuo. The residue was purified by columnchromatography (silica gel, EtOAc-PE) to afford the product 2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Tao, Chuanzhou; Wang, Bin; Sun, Lei; Yi, Jiuyin; Shi, Dahua; Wang, Jian; Liu, Weiwei; Journal of Chemical Research; vol. 41; 1; (2017); p. 25 – 29;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Brief introduction of (E)-Cinnamonitrile

The synthetic route of 1885-38-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1885-38-7, A common heterocyclic compound, 1885-38-7, name is (E)-Cinnamonitrile, molecular formula is C9H7N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of dimethyl-3-p-tolyloxiranyl-2,2-dicarboxylate(1a, 0. 25 g, 1 mmol, 1 equiv) and benzonitrile (2a, 0.52g, 5mmol, 5 equiv) was added SnCl4 (0.12 mL, 1 mmol, 1 equiv) at 0C. The reaction mixture was then stirred at r.t. until the startingmaterials were consumed as indicated by TLC analysis. Themixture was poured into 50 mL aq sat. NaHCO3 solution andextracted with CH2Cl2 (3 × 25 mL). The combined organic layerwas rinsed with H2O, brine, and dried over anhydrous MgSO4.The solvent was evaporated off to get a residue which was thenpurified by flash chromatography to give pure product 3aa (269mg, 76%). 1H NMR (500 MHz, CDCl3): delta = 8.11 (d, J = 7.8 Hz, 2 H),7.54 (t, J = 7.5 Hz, 1 H), 7.46 (t, J = 7.5 Hz, 2 H), 7.19 (d, J = 7.9 Hz,2 H), 7.11 (d, J = 7.9 Hz, 2 H), 6.15 (s, 1 H), 3.90 (s, 3 H), 3.20 (s, 3H), 2.31 (s, 3 H). 13C NMR (125 MHz, CDCl3): delta = 167.6, 166.0,162.9, 138.2, 133.5, 132.2, 128.9, 128.9, 128.6, 128.0, 126.6,90.7, 76.6, 53.8, 52.5, 21.3. HRMS: m/z calcd for C20H19NO5 [M +H+]: 354.1336; found: 354.13302

The synthetic route of 1885-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Hai; Zeng, Xiaofei; Xie, Yan; Zhong, Guofu; Synlett; vol. 26; 12; (2015); p. 1693 – 1696;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Research on new synthetic routes about C9H7N

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (E)-Cinnamonitrile, its application will become more common.

Related Products of 1885-38-7,Some common heterocyclic compound, 1885-38-7, name is (E)-Cinnamonitrile, molecular formula is C9H7N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under a nitrogen atmosphere, a mixture of [RhCl(C2H4)2]2 (1.8 mg,0.0045 mmol) and ligand L1f (3.7 mg, 0.0099 mmol) in toluene(1 mL) was stirred at r.t. for 15 min, at which time arylboronic acid(0.60 mmol) was added, followed by cyanoalkenes (0.30 mmol),aqueous KOH (0.75 M in H2O, 0.20 mL, 0.15 mmol) and toluene(1 mL). The reaction was stirred at 80 C for 12 h, after which thereaction mixture was concentrated in vacuo and purified by silica gelflash column chromatography (petroleum ether/ethyl acetate as eluent)to give the product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (E)-Cinnamonitrile, its application will become more common.

Reference:
Article; Xue, Feng; Zhu, Yong; Qi, Xiaolei; Journal of Chemical Research; vol. 42; 6; (2018); p. 300 – 304;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Discovery of (E)-Cinnamonitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Cinnamonitrile, other downstream synthetic routes, hurry up and to see.

Application of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(b) (2E)-3-Phenyl-2-propenimidamide; Cinnanionitrile (25.0 g, 194 mmol) was dissolved in EtOH. The solution was cooled to 0 0C and HCl gas bubbled through the solution for 30 minutes. The solution was stirred at ambient temperature for 1 h and then concentrated under vacuum. The residue was dissolved in EtOH (100 niL), cooled to 00C and a solution of NH3/Me0H (7M, 69 mL, 484 mmol) was added dropwise through an addition funnel. Once added, the solution was allowed to warm to ambient temperature and stirred overnight and the resulting NH4Cl was filtered off. The solution was concentrated under vacuum and the resulting product was used without further purification (28.6 g crude). LC-MS: m/z 147.4 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Cinnamonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/3690; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some scientific research about 1885-38-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Cinnamonitrile, and friends who are interested can also refer to it.

Synthetic Route of 1885-38-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1885-38-7 name is (E)-Cinnamonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of cheliensisin A (548 mg, 2 mmol) in PhCN (10 mL) at -20 C, a solution of BF3·OEt2 (668 muL, 2 mmol) in PhCN (5 mL) was added over 15 min. The reaction completed in 1 h with TLC judgment. A saturated aqueous NaHCO3 solution (12 mL) was then added to quench the reaction. The mixture was extracted with dichloromethane (100 mL × 3). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was subjected to flash chromatography on silica gel (ethyl acetate/petrol ether = 1:3) to give compounds 2a and 2b as white foams in 34% (257 mg) and 53% (403 mg), respectively.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Cinnamonitrile, and friends who are interested can also refer to it.

Reference:
Article; Deng, Xu; Su, Jia; Zhao, Yu; Peng, Li-Yan; Li, Yan; Yao, Zhu-Jun; Zhao, Qin-Shi; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4238 – 4244;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Analyzing the synthesis route of 1885-38-7

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1885-38-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1885-38-7, name is (E)-Cinnamonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of (E)-Cinnamonitrile

General procedure: Under a nitrogen atmosphere, a mixture of [RhCl(C2H4)2]2 (1.8 mg,0.0045 mmol) and ligand L1f (3.7 mg, 0.0099 mmol) in toluene(1 mL) was stirred at r.t. for 15 min, at which time arylboronic acid(0.60 mmol) was added, followed by cyanoalkenes (0.30 mmol),aqueous KOH (0.75 M in H2O, 0.20 mL, 0.15 mmol) and toluene(1 mL). The reaction was stirred at 80 C for 12 h, after which thereaction mixture was concentrated in vacuo and purified by silica gelflash column chromatography (petroleum ether/ethyl acetate as eluent)to give the product

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1885-38-7.

Reference:
Article; Xue, Feng; Zhu, Yong; Qi, Xiaolei; Journal of Chemical Research; vol. 42; 6; (2018); p. 300 – 304;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Extended knowledge of (E)-Cinnamonitrile

The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of cinnamonitrile (2.5 g, 19.38 mmol) in MeOH (50 mL) was added Br2 (6.2 g, 38.76 mmol) dropwise at 0oC. Then the reaction mixture was warmed to room temperature and stirred overnight. The resulting mixture was poured into water (50 mL) and basified with solid NaHCO3. The resulting mixture was extracted with EtOAc (3*50 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by CC on silica gel eluting with PE : EA =10:1 to PE : EA =4:1 to give 2,3-dibromo-3- phenylpropanenitrile (3.2 g) as a oil. (yield, 57.7 %). LC/MS (ESI, m/z): [M+1]+ = 290.1.

The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KYMERA THERAPEUTICS, INC.; MAINOLFI, Nello; JI, Nan; KLUGE, Arthur F.; (282 pag.)WO2019/140387; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts