Reference of 1885-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1885-38-7, name is (E)-Cinnamonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of cinnamonitrile (2.5 g, 19.38 mmol) in MeOH (50 mL) was added Br2 (6.2 g, 38.76 mmol) dropwise at 0oC. Then the reaction mixture was warmed to room temperature and stirred overnight. The resulting mixture was poured into water (50 mL) and basified with solid NaHCO3. The resulting mixture was extracted with EtOAc (3*50 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by CC on silica gel eluting with PE : EA =10:1 to PE : EA =4:1 to give 2,3-dibromo-3- phenylpropanenitrile (3.2 g) as a oil. (yield, 57.7 %). LC/MS (ESI, m/z): [M+1]+ = 290.1.
The synthetic route of (E)-Cinnamonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KYMERA THERAPEUTICS, INC.; MAINOLFI, Nello; JI, Nan; KLUGE, Arthur F.; (282 pag.)WO2019/140387; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts