Category: 1885-29-6

Fu, Zhengqiang published the artcileManganese Catalyzed Direct Amidation of Esters with Amines, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amide preparation; ester amine amidation manganese catalyst.

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations

Journal of Organic Chemistry published new progress about Amidation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Qi-Liang published the artcilePalladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent, Related Products of nitriles-buliding-blocks, the main research area is bromobenzamide preparation; benzamide preparation electrochem bromination palladium catalyst ammonium bromide.

The palladium-catalyzed electrochem. C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chem. oxidants and provides an alternative method for the synthesis of aryl bromides.

Organic Letters published new progress about Amidation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Fabin published the artcileA terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl halide aniline amination palladium complex catalyst.

A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides ArX (Ar = Ph, 2-methoxyphenyl, 4-cyanophenyl, etc.; X = Cl, Br, I) with 1° anilines RNH2 (R = Ph, 2-nitrophenyl, 2,5-dimethylphenyl, etc.), especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.

Journal of Catalysis published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vijeta, Arjun published the artcileAn Integrated Carbon Nitride-Nickel Photocatalyst for the Amination of Aryl Halides Using Sodium Azide, Computed Properties of 1885-29-6, the main research area is primary aniline preparation; haloarene sodium azide amination integrated carbon nitride nickel photocatalyst; Carbon Nitride; Green Chemistry; Heterogeneous Catalysis; Organic Synthesis; Photocatalysis.

A photocatalytic protocol for the selective synthesis of primary anilines RNH2 [R = Ph, 4-BrC6H4, 3-pyridyl, etc.] via cross-coupling of a wide range of aryl/heteroaryl halides with sodium azide using a photocatalyst powder consisting of nickel(II) deposited on mesoporous carbon nitride (Ni-mpg-CNx) was reported. This heterogeneous photocatalyst contained a high surface area with a visible light-absorbing and adaptive “”built-in”” solid-state ligand for the integrated catalytic Ni site. The method displayed a high functional group tolerance, required mild reaction conditions, and benefited from easy recovery and reuse of the photocatalyst powder. Thereby, it overcame the need of complex ligand scaffolds required in homogeneous catalysis, precious metals and elevated temperatures/pressures in existing protocols of primary anilines synthesis. The reported heterogeneous Ni-mpg-CNx held potential for applications in the academic and industrial synthesis of anilines and exploration of other photocatalytic transformations.

Angewandte Chemie, International Edition published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, COA of Formula: C7H6N2, the main research area is ortho phenylenediamine preparation regioselective radical arene amination; monoalkyl amine benzimidazole benzotriazole preparation; anionic substrate radical cation regioselective radical amination.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Jing published the artcilePalladium-Catalyzed Sequential C-H Activation/Amination with Diaziridinone: An Approach to Indoles, COA of Formula: C7H6N2, the main research area is iodostyrene diaziridinone palladium catalyst bond activation amination tandem; indole preparation.

Indoles are an important class of mols. This paper describes an efficient palladium-catalyzed synthesis of indoles from 2-iodostyrenes and di-t-butyldiaziridinone with a simultaneous installation of two C-N bonds. The reaction process likely proceeds through the oxidative insertion of Pd to aryl iodide and subsequent vinyl C-H activation to from a pallada(II)cycle intermediate, which is bisaminated by di-t-butyldiaziridinone to give the indole product.

Organic Letters published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Leanez, Jacques published the artcileAnti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis, Product Details of C7H6N2, the main research area is Leishmania macrophage spiro dihydroquinoline oxindole sterol antileishmania; Leishmania braziliensis; chemotherapy; parasite internal regulation; spiro dihydroquinoline-oxindoles; squalene epoxidase inhibitors; sterol pathway.

Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3·OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and evaluated at different stages of the life cycle of Leishmania braziliensis parasites, responsible for cutaneous leishmaniasis in South America. Among them, the 8-ethyl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-3,4-dihydro-1H-spiro[indoline-3,2′-quinolin]-2-one called JS87 was able to inhibit the growth of promastigotes without affecting the mammalian cells viability, and to decrease the number of intracellular amastigotes of L. braziliensis. This spiro compound was found to act through the alteration of parasite internal regulation by disrupting the regulatory volume decrease (RVD), and to affect the sterol biosynthetic pathway at level of squalene epoxidase (SE) enzyme. These results revealed that the spiro annulation between quinoline and oxindole scaffolds enhances the anti-leishmanial activity, and could assist in the development of potent quinoline-oxindole hybrids against Leishmania braziliensis, the main etiol. agent of cutaneous leishmaniasis in South America.

Experimental Parasitology published new progress about Apoptosis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vidyacharan, Shinde published the artcileContinuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules, COA of Formula: C7H6N2, the main research area is aryldiazonium indazole arylation visible light continuous flow; arylindazole regioselective preparation; visible light arylation promotor; continuous flow micro reaction technol; C−H activation; drug synthesis; flow chemistry; organocatalysis; photocatalysis.

A continuous-flow homogeneous photocatalytic method has been devised for the direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3-arylated scaffolds of biol. interest in a fast (1 min), single-step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technol. is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal-free conditions, whereas the reported methods required multiple steps and much longer reaction times (18-24 h).

ChemSusChem published new progress about Arylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Yu published the artcileRoom-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is carbon dioxide quinazoline dione DES pressure high efficiency temperature.

Highly efficient and sustainable conversion of CO2 into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure is challenging. Deep eutectic solvents (DESs) are considered as the green solvents of the 21st century, which are also designable with high tunability and high atom efficiency. Here, DESs are for the first time used to catalyze the CO2 conversion into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure with high efficiency and nearly 100% yield. This work provides a sustainable way for the efficient conversion of CO2 into quinazoline-2,4(1H,3H)-dione by DESs at room temperature and atm. pressure.

Reaction Chemistry & Engineering published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Chieh-Kai published the artcileEnvironmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation, HPLC of Formula: 1885-29-6, the main research area is nafion quinoline environmentally microwave irradiation cyclization.

Herein, we report a facile synthetic methodol. for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chem. structures were confirmed by X-ray single-crystal diffraction anal. and the related data were provided. The plausible reaction mechanism studies are also discussed.

Catalysts published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts