Category: 1885-29-6

Song, Wangze published the artcileCopper-catalyzed tandem annulation/enol nucleophilic addition to access multisubstituted indoles, HPLC of Formula: 1885-29-6, the main research area is indole preparation copper catalyst; propargylic alc enol nucleophile tandem annulation enol nucleophilic addition.

A method to access various multisubstituted indoles from propargylic alcs. and readily available enol nucleophiles by copper-catalyzed tandem annulation/enol nucleophilic addition has been developed. Compared to the expensive metal catalysts such as platinum, gold, silver, and palladium used previously, the most economical copper(I) catalyst could achieve this reaction efficiently. The fused heterocyclic compounds, pyrrolo[1,2-a]indoles, could be afforded by further transformation of the products. The allyl cation intermediate may be involved in the mechanism.

Organic & Biomolecular Chemistry published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Ankit published the artcileBase-Promoted Synthesis of Polysubstituted 4-Aminoquinolines from Ynones and 2-Aminobenzonitriles under Transition-Metal-Free Conditions, Application In Synthesis of 1885-29-6, the main research area is aminoquinoline preparation; ynone aminobenzonitrile tandem aza Michael addition intramol annulation; aminonaphthyridine preparation; aminonicotinonitrile ynone aza Michael addition intramol annulation.

A transition-metal-free and base-promoted one-pot reaction of ynones with 2-aminobenzonitriles was described. The reaction was initiated through sequential aza-Michael addition/intramol. annulation to afford multisubstituted 4-aminoquinolines I [R1 = Ph, 2-thienyl, 4-MeC6H4, etc.; R2 = Ph, 4-MeC6H4, 3-thienyl, etc.; R3 = H, 6,7-di-MeO, 6-F, etc.; X = CH] and 4-amino-1,8-naphthyridines I [X = N] in good to excellent yields. Operational simplicity, high atom-economy with broad substrate scope made this protocol more attractive. Also, the gram-scale synthesis and further transformation of the product were studied. Addnl., 2-haloarylyones as substrate provided N-arylquinolones/1,8-naphthyridin-4-ones II [R4 = H, 4-Me, 4,5-di-MeO; Y = CH, N] as the sole product via the SNAr mechanism.

Advanced Synthesis & Catalysis published new progress about Aza-Michael reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Chen published the artcilePalladium-Catalyzed Carbamoyl-Carbamoylation/ Carboxylation/Thioesterification of Alkene-Tethered Carbamoyl Chlorides Using Mo(CO)6 as the Carbonyl Source, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl oxindole preparation; alkene tethered carbamoyl chloride carbamoylation palladium catalyst.

A palladium-catalyzed carbamoyl-carbamoylation/carboxylation/thioesterification of alkene-tethered carbamoyl chlorides such as I [R1 = H, 5-Cl, 7-Me, etc.; R2 = Bn, PMB; R3 = Me, n-Bu, Ph, etc.] using Mo(CO)6 as the carbonyl source was reported. The reactions were typically performed with good functional group compatibility and tolerated different nucleophiles (amines, alcs., phenols, thiols and water), which provided amidated/esterificated/thioesterificated/carboxylated oxindoles or lactams such as II [R4 = Ph, 2-tolyl, 1-naphthyl, etc.; R5 = H, Me] bearing an all-carbon quaternary stereocenter under CO gas-free conditions. Furthermore, natural product mutation and divergent late-stage derivatization were the important practical features.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Youyoung published the artcileIr(III)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles, Category: nitriles-buliding-blocks, the main research area is alkenyl arylamine iridium catalyst electrooxidation intramol dehydrogenation coupling; indole preparation.

An iridium(III)-catalyzed electrooxidative intramol. dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines was described. The developed method allowed the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggested that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fu, Zhengjiang published the artcileConversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl nitrile preparation green chem; malononitrile aryl carboxylic acid decarboxylative cyanation copper catalyst; azodimethylbutyronitrile aryl carboxylic acid decarboxylative cyanation copper catalyst.

Here, used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids RC(O)OH (R = 2-nitrophenyl, 2,4,6-trimethoxyphenyl, 3-methyl-1-benzothiophen-2-yl, etc.) bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles RCN from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols.

Organic & Biomolecular Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Yan published the artcileRhodium-Catalyzed Reaction of Azobenzenes and Nitrosoarenes toward Phenazines, SDS of cas: 1885-29-6, the main research area is azobenzene nitrosoarene rhodium annulation catalyst; phenazine preparation.

A rhodium-catalyzed annulative reaction between azobenzenes and nitrosoarenes has been developed, leading to a series of phenazines I (R1 = H, 2-Cl, 2-MeO, 2-Me, etc.; R2 = H, 2-Me, 2-t-Bu, 2-Br, etc.) in moderate to good yields. This procedure proceeds with sequential chelation-assisted addition of aryl C-H to nitrosoarenes and ring closure by electrophilic attack of azo group to aryl. During this transformation, the azo group served as not only a traceless directing group but also a building block in the final products.

Organic Letters published new progress about Aromatic compounds, nitroso Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qiu, Di published the artcileVisible Light-Driven, Photocatalyst-Free Arbuzov-Like Reaction via Arylazo Sulfones, Category: nitriles-buliding-blocks, the main research area is visible light Arbuzov reaction arylazo sulfone phosphite; heteroaryl aryl phosphonate preparation.

A visible light-induced formation of Aryl-Phosphorous bonds starting from arylazo sulfones and triaryl (or trialkyl)phosphites in the absence of any photoredox catalyst and any additives was developed. This reaction showed a broad substrate scope and afforded (hetero)aryl phosphonates in good yields and in up to the gram scale.

Advanced Synthesis & Catalysis published new progress about Azo compounds, aromatic Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mihai, Madalina T. published the artcilePara-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is para selective carbon hydrogen bond borylation aniline phenol benzylamine.

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Ir-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. The authors describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcs.) and uses standard borylation ligands. The authors’ strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a Bu4N cation. The authors hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Xing published the artcileCu-Mediated C-H Thioetherification of Arenes at Room Temperature, HPLC of Formula: 1885-29-6, the main research area is arene ethylene sulfide thioetherification; aryl alkyl sulfide preparation hydrolysis cyclization; benzoxathiepinone preparation.

Cu-mediated C-H thioetherification of arenes with ethylene sulfide has been developed using a readily removable directing group. The reaction proceeded at room temperature, and a variety of sensitive functional groups including chloro, bromo, and vinyl were well tolerated. The thiolated products could be converted to the seven-membered benzoxathiepinones derivatives by a sequence of hydrolysis-lactonization reactions.

Organic Letters published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Xiang published the artcileGold-catalyzed cyclization of 1-(2′-azidoaryl)propynols: synthesis of polysubstituted 4-quinolones, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinolone preparation; azidoaryl propynol cyclization gold catalyst.

An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones I (R1 = C6H5, 4-NCC6H4, 4-FC6H4, etc.; R2 = H, 7-Me, 6-Br, etc.) from 1-(2′-azidoaryl)propynols II is described. The reaction underwent an intramol. nucleophilic attack of the azide group to the Au-activated triple bonds in a 6-endo-dig manner and subsequent gold-assisted expulsion of N2 to furnish an α-imino gold carbene intermediate, which triggers a 1,2-carbon migration and finally is converted to 2,3-disubstituted 4-quinolone.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts