Category: 1885-29-6

Wang, Guangzhu published the artcileNi-Catalyzed enantioselective reductive arylcyanation/cyclization of N-(2-iodo-aryl) acrylamide, HPLC of Formula: 1885-29-6, the main research area is iodophenyl acrylamide phenylmalononitrile nickel enantioselective reductive cyanation Heck cyclization; cyanomethyl oxoindole preparation.

A Ni/(S,S)-BDPP-catalyzed intramol. Heck cyclization of N-(2-iodo-aryl)acrylamides with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. By utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asym. alkene arylcyanation.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acrylamides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Xianqing published the artcilePd-Catalyzed Regiodivergent Synthesis of Diverse Oxindoles Enabled by the Versatile Heck Reaction of Carbamoyl Chlorides, Quality Control of 1885-29-6, the main research area is propenylphenyl carbamic chloride alkene palladium tandem heterocyclization Heck reaction; alkenyl oxindole regioselective diastereoselective preparation; alkene phenylvinyl phenylcarbamoyl chloride palladium tandem heterocyclization Heck reaction; alkenylphenyl oxindole regioselective diastereoselective preparation; alkenylalc phenylvinyl phenylcarbamoyl chloride palladium tandem heterocyclization Heck reaction; formylalkyl phenyloxindole regioselective diastereoselective preparation.

A miscellaneous oxindole synthesis bearing an all-carbon quaternary center, enabled by Pd-catalyzed intramol. cyclization followed by multiple intermol. Heck reactions of both easily accessible alkene-tethered carbamoyl chlorides and olefins was reoprted. This protocol obviates the use of prefunctionalized olefinic reagents, exhibited excellent functional group tolerance and features fascinating reactive versatility.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Osinubi, Adejoke published the artcileSynthesis and in vitro anticancer activities of substituted N-(4′-nitrophenyl)-L-prolinamides, Related Products of nitriles-buliding-blocks, the main research area is substituted nitrophenyl prolinamide preparation in vitro anticancer human; aryl proline preparation amine amidation; para fluoronitrobenzene thionyl chloride proline DMF catalyst condensation; anti-cancer agents; biomolecules; carcinoma cell lines; cytotoxicity; pyrrolidine-2-carboxamides.

Synthesis of N-(4′-substituted phenyl)-L-prolinamides I [R1 = CN, NO2; R2 = H, OH; R3 = H, Me, cyclohexyl, etc.; R4 = Pr, cyclohexyl, SO2C6H5, etc.; R3R4 = 4-morpholinyl, 2-isoindolinyl] via amidation reaction of N-aryl-L-prolines II with amines in presence of SOCl2 was described. Intermediate compounds II were obtained by condensation of p-fluoronitrobenzene with L-proline under aqueous-alc. basic conditions. The cytotoxicities of I against four human carcinoma cell lines (SGC7901, HCT-116, HepG2 and A549) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; with good tumor inhibitory activities (79.50 ± 1.24%-50.04 ± 1.45%) against HepG2. I [R1 = NO2; R2 = H; R3 = R4 = n-butyl] exhibited the best anti-tumor activity against A549 with percentage cell inhibition of 95.41 ± 0.67% at 100μM. Likewise, I [R1 = NO2; R2 = H; R3 = Me; R4 = Ph] (70.13 ± 3.41%) and I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (83.36 ± 1.70%) displayed stronger antineoplastic potencies against A549 than the standard, 5-fluorouracil (64.29 ± 2.09%), whereas I [R1 = NO2; R2 = H; R3 = R4 = n-butyl] (93.33 ± 1.36%) and I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (81.29 ± 2.32%) outperformed the reference (81.20 ± 0.08%) against HCT-116. SGC7901 Showed lower percentage cell viabilities with I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (8.02 ± 1.54%) and I [R1 = NO2; R2 = H; R3 = R4 = cyclohexyl] (27.27 ± 2.38%). These results underscored the antiproliferative efficacies of L-prolinamides while exposing I [R1 = NO2; R2 = H; R3 = H, Me; R4 = Ph, 4-NO2C6H4] as promising broad-spectrum anti-cancer agents. Structure-activity relationship studies were also discussed.

Royal Society Open Science published new progress about Amidation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guan, Dan published the artcileMetal-free Efficient Method for the Synthesis of N-(2-haloethyl)benzamides through the Ring-opening of 2-oxazolines, HPLC of Formula: 1885-29-6, the main research area is dihydrooxazolylphenyl amide preparation halosuccinimide ring opening halogenation; amido haloethyl benzamide preparation.

An efficient, metal-free C-H halogenated method for the synthesis of β-halogenated carboxamides using non-corrosive NXS (X=Cl, Br) as the halogenated source and ammonium thiocyanate (NH4SCN) as the additive was proposed and accomplished. Various substituted 2-oxazolines efficiently afforded the corresponding β-halogenated carboxamides via a ring-opening reaction in good yields. The characteristic features of this reaction include readily available materials, mild reaction conditions and functional groups tolerance.

ChemistrySelect published new progress about Amides, halo Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tyagi, Aparna published the artcileBroensted acid-catalyzed epoxide ring-opening using amine nucleophiles: A facile access to β-amino alcohols, Quality Control of 1885-29-6, the main research area is amino alc beta synthesis; styrene oxide epoxide ring opening aniline Broensted acid catalyst; ring opening reaction mechanism kinetics Hammett equation; Suzuki Miyaura Cross coupling reaction; aniline; metal-free; phenyl oxirane; β-amino alcohols.

A mild, efficient, and metal-free synthetic protocol for the synthesis of β-amino alcs. is reported. The reaction proceeds at room temperature with only 0.5 mol % catalyst loading and affords β-amino alc. derivatives in excellent yield. This protocol is well-tolerated by a wide range of styrene oxide and aniline derivatives A notably efficacious gram-scale synthesis is also reported with a high TON=842. Further, the Hammett correlation study was also performed to identify the rate-determining step.

Chemistry – An Asian Journal published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yao, Hua published the artcileCyanomethylation of the Benzene Rings and Pyridine Rings via Direct Oxidative Cross-Dehydrogenative Coupling with Acetonitrile, SDS of cas: 1885-29-6, the main research area is arylacetonitrile preparation regioselective green chem; arylamine acetonitrile dehydrogenative coupling cyanomethylation.

A novel and efficient approach for the amine-directed dehydrogenative C(sp2)-C(sp3) coupling of arylamines RNH2 (R = Ph, 5-chloropyridin-2-yl, pyrazin-2-yl, etc.) with acetonitrile was reported by using FeCl2 as the catalyst. Arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles R1CH2CN (R1 = 2-amino-5-chloropyridin-3-yl, 2-aminophenyl, 6-amino-1,3-benzothiazol-7-yl, etc.) in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Hao published the artcileA Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation, COA of Formula: C7H6N2, the main research area is cis hydrocarbazole preparation diasteroselective; allylic aniline arylcyanation nickel Lewis acid catalyst.

A strategy for the synthesis of cis-hydrocarbazoles I [R1 = H, 6-Me, 7-F, etc.; R2 = Me, Et, Bn; R3 = H, Me; R4 = H, Me; R3R4 = O(CH2)2O] with a C3 quaternary carbon center was developed through Ni/Lewis acid dual-catalyzed arylcyanation of allylic anilines. A wide array of cis-hydrocarbazoles was accessed with high diastereoselectivities and atom economies in a good yield. The rich chem. of the installed nitrile group was demonstrated in the preparation of tryptamine- and tryptophol-derived cis-hydrocarbazoles.

Journal of Organic Chemistry published new progress about Carbazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rakshit, Amitava published the artcilePd(II)-Catalyzed Synthesis of Furo[2,3-b]pyridines from β-Ketodinitriles and Alkynes via Cyclization and N-H/C Annulation, Computed Properties of 1885-29-6, the main research area is furopyridine preparation; ketodinitrile alkyne annulation palladium catalyst.

A Pd(II)-catalyzed synthesis of furopyridines, e.g., I has been developed from β-ketodinitriles, e.g., 2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanedinitrile and alkynes, e.g., diphenylacetylene via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C=C, C-O, C-N, and C=N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations.

Organic Letters published new progress about C-C bond formation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shit, Sudip published the artcileSynthesis of Spiro[furan-2,1′-isoindolin]-3′-ones from 2-(4-Hydroxybut-1-yn-1-yl)benzonitriles and Aryl Aldehydes under the Action of Triflic Acid, Quality Control of 1885-29-6, the main research area is spiro furanisoindolinone diastereoselective preparation; hydroxybutynyl benzonitrile aryl aldehyde Prins Ritter ring opening addition.

The synthesis of spiro[furan-2,1′-isoindolin]-3′-ones I [R1 = H, 5-Me, 6-Cl, 6-Br; R2 = H, Me, Et; Ar = Ph, 4-FC6H4, 2-BrC6H4, etc.] from 2-(4-hydroxybut-1-yn-1-yl)benzonitriles and aryl aldehydes was demonstrated. It involved the initial formation of dihydrofuranylideneisoindolinone via intramol. sequential Prins and Ritter reactions, followed by the ring opening of the furanyl moiety to generate N-acyliminium ions and alcs. for the final cyclization reaction, and the spiro-cyclic compounds were produced in moderate to good yields. It was a one-pot, three-component reaction in which one new quaternary carbon, two five-membered rings, one C-N bond, two C-O bonds and one C-C bond are formed. The reaction was carried out with a Bronsted acid from 0°C to room temperature within a short period of time.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yuan, Shuo published the artcile“”On-Water”” Palladium-Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4-Arylquinazolines, Synthetic Route of 1885-29-6, the main research area is aryl quinazoline preparation green chem; benzonitrile preparation arylboronic acid tandem heterocyclization palladium catalyst; cascade reactions; catalysis; on-water synthesis; palladium; quinazolines.

The quinazoline scaffold is prevalent in pharmaceutically relevant mols. that show diverse biol. activities. An efficient “”on-water”” palladium-catalyzed tandem cyclization reaction from com. available arylboronic acids RB(OH)2 (R = Ph, 3-nitrophenyl, naphthalen-1-yl, etc.) and benzonitriles (E)-2-CN-R1C6H4N=C(R2)N(Me)2 [R1 = H, 5-Me, 4,5-(OMe)2, etc.; R2 = H, Me] that enable the rapid access to 4-arylquinazoline scaffolds I [R3 = H, 7-Me, 6,7-(OMe)2, etc.] in good to excellent yields (45 examples, up to 98% yield) was reported. This protocol has shown good functional group tolerance and broad substrate scope. The reaction was also performed on a gram scale and successfully applied to the synthesis of the highly potent and selective PI3Kδ inhibitor II, showing the practicability and synthetic utility of the protocol. In this reaction, the quinazoline scaffold I is efficiently constructed with the simultaneous formation of one C-C bond and one C-N bond. Collectively, the protocol could serve as an alternative strategy to synthesize biol. important quinazoline scaffolds.

Chemistry – A European Journal published new progress about Bond formation catalysts (C-N, C-C). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts