Category: 1885-29-6

Yang, Tao published the artcileThe Cascade Methylation/Cyclization of ortho-Cyanoarylacrylamides with Dicumyl Peroxide, Quality Control of 1885-29-6, the main research area is methylquinolinedione preparation; cyanoarylacrylamide dicumyl peroxide cascade methylation cyclization.

A radical cascade methylation/cyclization of ortho-cyanoarylacrylamides was developed by utilizing dicumyl peroxide as a methylation reagent. This transformation provides a simple and straight forward approach to methylated quinoline-2,4(1H,3H)-diones, and exhibits a wide substrate scope. Furthermore, this reaction could be readily scaled up. A possible mechanism is also proposed.

European Journal of Organic Chemistry published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Yiwen published the artcileCobalt-catalyzed carbonylative cyclization of N-(2-Vinylphenyl)picolinamides to access (NH)-quinolin-2(1H)-ones, Related Products of nitriles-buliding-blocks, the main research area is TFBen vinylphenyl picolinamide copper catalyst regioselective carbonylative cyclization; quinolinone preparation.

A cobalt-catalyzed carbonylative cyclization of N-(2-vinylphenyl)picolinamides for the construction of (NH)-quinolin-2(1H)-one scaffolds was developed. In this reaction, various free (NH)-quinolin-2(1H)-ones were produced in good yields (up to 92%) by employing benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group. Moreover, several synthetic transformations of the obtained (NH)-quinolin-2(1H)-ones were performed and a facile and rapid access to the core skeleton of Tipifarnib was realized to demonstrate the utility of this protocol.

Molecular Catalysis published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Frost, Grant B. published the artcileChemoselectivity for Alkene Cleavage by Palladium-Catalyzed Intramolecular Diazo Group Transfer from Azide to Alkene, Product Details of C7H6N2, the main research area is benzyl alkenyl phenyl carbamoyl azide preparation palladium catalyst chemoselective; benzo dihydroquinazolinone preparation; alkene cleavage; azides; cycloreversion; diazo group transfer; palladium.

A palladium-catalyzed intramol. azide to alkene DGT, which granted chemoselectivity over competing aziridination. The data supported a catalytic cycloreversion mechanism distinct from other known metal-catalyzed azide/alkene reactions: nitrenoid/metalloradical and (3+2) cycloadditions Kinetics experiments revealed an unusual mechanistic profile in which the catalyst was not operative during the rate-controlling step, rather, it was active during the product-determining step. Catalytic DGT was used to synthesize N-heterocyclic quinazolinones, a medicinally relevant structural core. On the competing aziridination and subsequent ring expansion to another N-heterocyclic core structure of interest, benzodiazepinones was also reported.

Chemistry – A European Journal published new progress about Chemoselectivity. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gayyur published the artcileSynergetic copper/zinc catalysis: synthesis of aryl/heteroaryl-fused 1H-pyrrolo[3,2-c]pyridines, Application In Synthesis of 1885-29-6, the main research area is aryl pyrrolopyridine preparation; amino arylnitrile ynamide cyclization reaction copper zinc catalyst.

A synergetic copper/zinc-catalyzed one-step annulation reaction of 2-amino (hetero)arylnitriles e.g., 2-aminobenzonitrile with ynamide-derived buta-1,3-diynes R1N(S(O)2R)CCCCN(S(O)2R)R1 (R = Bn, Me; R1 = Me, Ph, 4-methylphenyl, etc.) to deliver 1H-pyrrolo[3,2-c]quinoline-2,4-diamine derivatives I (R2 = H, 8-Me, 7-Cl, 9-F, etc.) in moderate to good yields was reported. The annulation reaction follows a double cyclization pathway. The gram-scale synthesis of 1H-pyrrolo[3,2-c]quinoline-2,4-diamine proves the practicality of this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hachiya, Iwao published the artcileTitanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is iodoquinazoline aryl preparation iodination cyclization cyanophenyl benzamide.

Synthesis of 2-aryl-4-iodoquinazolines I (R1 = H, Cl, Me, R2 = 4-Cl, 4-F, 4-Br, H, Me, 2-Cl, 3-Cl, 3,5-Cl2) is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides II. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent analgesic agent.

ACS Omega published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Faroughi Niya, Homayoun published the artcileA One-pot Multicomponent Synthesis of Pyrroloacridine-1(2H)-one and 1,8-Dioxodecahydroacridine Derivatives Catalyzed by Salicylic Acid in Polyethylene Glycol, Quality Control of 1885-29-6, the main research area is pyrroloacridinone dioxodecahydroacridine preparation green chem; aniline aldehyde dimedone multicomponent reaction salicylic acid catalyst; isatine aniline dimedone multicomponent reaction.

Two efficient, straightforward and ecofriendly protocols are described for one-pot multicomponent synthesis of pyrrolo[2,3,4-kl]acridin and 1,8-dioxodecahydroacridine derivatives using salicylic acid as the catalyst and polyethylene glycol (PEG-200) as the promoter solvent. The reported approach shows significant advantages, such as operational simplicity, the use of an inexpensive and nontoxic catalyst, high yields, short reaction time, and the product isolation ease without chromatog. separation An important feature of this work is the route of the reaction that depends on the reaction solvent.

Polycyclic Aromatic Compounds published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abel-Snape, Xavier published the artcileSynthesis of Indenes and Benzofulvenes via a Palladium-Catalyzed Three-Component Reaction, Formula: C7H6N2, the main research area is indene benzofulvene preparation palladium catalyst three component reaction.

A palladium-catalyzed three-component domino reaction to access indene derivatives is reported. This reaction proceeds via the sequential formation of three bonds: the first two resulting from inter- and intramol. carbopalladation and the final bond arising from an attack by a terminating nucleophilic reagent. Modifying the starting tether on the iodoarene led to either indenes or benzofulvenes. Three termination variations were compatible with this sequence, which furnished products in moderate to good yields. The oxabicycle used in this work acts as an acetylene surrogate, which is revealed in a postcatalytic retro-Diels-Alder step. A diastereomerically enriched mixture of oxabicyclic derivatives allowed for preliminary results for the enantioselective synthesis of indenes.

ACS Catalysis published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sajadi, Mahdieh Sadat published the artcileSynthesis of N-aryl-3H-indazol-3-imine and N-aryl-1H-indazol-3-amine via Na2WO4/H2O2 mediated by intramolecular N-N coupling, Quality Control of 1885-29-6, the main research area is arylindazolimine preparation disodium tungstate catalyst; aminoarylbenzimidamide intramol oxidative cyclization.

A fast and convenient method for synthesis of N-aryl-1H-indazol-3-amine and N-aryl-3H-indazol-3-imine compounds has been described via intramol. oxidative cyclization of the 2-amino-N’-arylbenzimidamide intermediates by Na2WO4/H2O2 in excellent yields. This procedure has several advantages such as mild reaction conditions, short reaction time, and excellent yields, making this methodol. practical.

Tetrahedron published new progress about Bond formation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mohammadinezhad, Arezou published the artcileCoII immobilized on an aminated magnetic metal-organic framework catalyzed C-N and C-S bond forming reactions: a journey for the mild and efficient synthesis of arylamines and arylsulfides, HPLC of Formula: 1885-29-6, the main research area is arylamine preparation; amine aryl halide cross coupling cobalt nanocatalyst; arylsulfide preparation; aryl halide thiol cross coupling cobalt nanocatalyst.

A simple and versatile method for the modification of a metal-organic framework (NH2-MIL53(Al)) in a step-wise manner was reported. To characterize the synthesized nanostructured catalyst, a variety of spectroscopic and microscopic techniques including FT-IR, XRD, BET, TEM, FE-SEM, EDX, EDX-mapping, TGA, XPS, VSM, ICP-OES and CHN have been employed. Fe3O4@AMCA-MIL53(Al)-NH2-CoII NPs, which benefit from small nanocrystalline size (10-30 nm, according to the XRD and TEM data) in combination with the coexistence of magnetic nanoparticles, a metal-organic framework, and cobalt species, were found to be an excellent environment catalyst to promote the C-N and C-S cross coupling reactions. A wide range of functional substrates including electron-withdrawing and electron-donating aryl halides RC6H4X (R = H, 2-O2N, 3-H3C, 4-CHO, etc.; X = I, Br, Cl) underwent the coupling reaction with aromatic/heteroaromatic/benzylic and aliphatic amines R1NH2 (R1 = Bu, 2-pyridy, 2-chlorobenzyl, 4-bromophenyl, etc.) and sulfides R2NH2 (R2 = 3-sulfanylpropyl, 4-nitrophenyl, 2-hydroxyethyl, etc.). The results demonstrated that the yields of the target products RC6H4NHR1/RC6H4SHR2 were good to excellent and the catalyst can be recycled for at least seven recycling runs without a discernible decrease in its catalytic activity. Furthermore, the heterogeneity studies (such as hot filtration and poisoning tests) efficiently confirmed that the as-synthesized nanostructured catalyst is heterogeneous and completely stable under the reaction conditions. This study inspires more interest in designing novel catalysts based on using low-cost metal ions (such as cobalt) in the field of cross coupling reactions.

New Journal of Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Louvel, Dan published the artcileMetal-Free Visible-Light Synthesis of Arylsulfonyl Fluorides: Scope and Mechanism, Quality Control of 1885-29-6, the main research area is arylsulfonyl fluoride preparation; diazonium salt DABSO fluorination photocatalyst visible light induced; arylsulfonyl fluorides; fluorine; mechanistic investigations; metal-free synthesis; organo-photoredox.

A series of arylsulfonyl fluorides I [R = H, 4-Me, 2-CN, etc.] was synthesized via organo-photoredox-induced nucleophilic fluorination of aryl diazonium salts with a SO2 source (DABSO). The reaction tolerated the presence of both electron-rich and -poor aryls and demonstrated a broad functional group tolerance. To shed the light on the reaction mechanism, several exptl. techniques were combined, including fluorescence, NMR and EPR spectroscopy as well as DFT calculations

Chemistry – A European Journal published new progress about Fluorination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts