Category: 1885-29-6

Manning, Trevor W. published the artcileStructure of an unusual tetracyclic deoxyguanosine adduct: Implications for frameshift mutagenicity of ortho-cyano nitroanilines, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is structure tetracyclic deoxyguanosine adduct frameshift mutagenicity orthocyanonitroaniline.

Nitroarom. compounds represent a major class of industrial chems. that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation to produce nitrenium electrophiles that covalently modify DNA to afford N-linked C8-2′-deoxyguanosine (C8-dG) lesions that can induce frameshift mutations, especially in CpG repeat sequences. In contrast, their monocyclic counterparts typically exhibit weak mutagenicity or a lack thereof, despite also undergoing bioactivation to afford N-linked C8-dG adducts. Recently, it has been reported that cyano substitution can greatly increase the mutagenicity of nitroaniline derivatives that are components of azo dyes. The basis of this “”cyano effect”” may be rooted in the formation of a novel polycyclic adduct arising from initial formation of the N-linked C8-dG adduct followed by a cyclization process involving N7 of dG and the ortho-CN group of the attached C8-aryl moiety to generate a quinazolinimine ring as part of a fused tetracyclic C8,N7-dG adduct structure. The present work structurally characterizes this novel cyclic adduct using a combination of optical spectroscopies, NMR anal., d. functional theory (DFT) calculations, and mol. dynamics (MD) simulations. Our data indicate that this highly fluorescent cyclic adduct adopts the promutagenic syn conformation and can stabilize the slipped mutagenic intermediate (SMI) within the CpG repeat of the NarI sequence, which is a hotspot for frameshift mutagenesis mediated by polycyclic N-linked C8-dG adducts. In contrast, the open para-CN (4-aminobenzontrile-derived) N-linked C8-dG adduct is less likely to disrupt the canonical B-form. Together, our results provide a rationale for the potent mutagenicity of cyano-substituted nitroaniline derivatives recently reported in frameshift-sensitive tester strains.

Chemical Research in Toxicology published new progress about Azo dyes. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Jing published the artcilePalladium-Catalyzed Sequential C-H Activation/Amination with Diaziridinone: An Approach to Indoles, COA of Formula: C7H6N2, the main research area is iodostyrene diaziridinone palladium catalyst bond activation amination tandem; indole preparation.

Indoles are an important class of mols. This paper describes an efficient palladium-catalyzed synthesis of indoles from 2-iodostyrenes and di-t-butyldiaziridinone with a simultaneous installation of two C-N bonds. The reaction process likely proceeds through the oxidative insertion of Pd to aryl iodide and subsequent vinyl C-H activation to from a pallada(II)cycle intermediate, which is bisaminated by di-t-butyldiaziridinone to give the indole product.

Organic Letters published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Leanez, Jacques published the artcileAnti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis, Product Details of C7H6N2, the main research area is Leishmania macrophage spiro dihydroquinoline oxindole sterol antileishmania; Leishmania braziliensis; chemotherapy; parasite internal regulation; spiro dihydroquinoline-oxindoles; squalene epoxidase inhibitors; sterol pathway.

Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3·OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and evaluated at different stages of the life cycle of Leishmania braziliensis parasites, responsible for cutaneous leishmaniasis in South America. Among them, the 8-ethyl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-3,4-dihydro-1H-spiro[indoline-3,2′-quinolin]-2-one called JS87 was able to inhibit the growth of promastigotes without affecting the mammalian cells viability, and to decrease the number of intracellular amastigotes of L. braziliensis. This spiro compound was found to act through the alteration of parasite internal regulation by disrupting the regulatory volume decrease (RVD), and to affect the sterol biosynthetic pathway at level of squalene epoxidase (SE) enzyme. These results revealed that the spiro annulation between quinoline and oxindole scaffolds enhances the anti-leishmanial activity, and could assist in the development of potent quinoline-oxindole hybrids against Leishmania braziliensis, the main etiol. agent of cutaneous leishmaniasis in South America.

Experimental Parasitology published new progress about Apoptosis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vidyacharan, Shinde published the artcileContinuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules, COA of Formula: C7H6N2, the main research area is aryldiazonium indazole arylation visible light continuous flow; arylindazole regioselective preparation; visible light arylation promotor; continuous flow micro reaction technol; C−H activation; drug synthesis; flow chemistry; organocatalysis; photocatalysis.

A continuous-flow homogeneous photocatalytic method has been devised for the direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3-arylated scaffolds of biol. interest in a fast (1 min), single-step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technol. is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal-free conditions, whereas the reported methods required multiple steps and much longer reaction times (18-24 h).

ChemSusChem published new progress about Arylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Yu published the artcileRoom-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is carbon dioxide quinazoline dione DES pressure high efficiency temperature.

Highly efficient and sustainable conversion of CO2 into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure is challenging. Deep eutectic solvents (DESs) are considered as the green solvents of the 21st century, which are also designable with high tunability and high atom efficiency. Here, DESs are for the first time used to catalyze the CO2 conversion into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure with high efficiency and nearly 100% yield. This work provides a sustainable way for the efficient conversion of CO2 into quinazoline-2,4(1H,3H)-dione by DESs at room temperature and atm. pressure.

Reaction Chemistry & Engineering published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Chieh-Kai published the artcileEnvironmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation, HPLC of Formula: 1885-29-6, the main research area is nafion quinoline environmentally microwave irradiation cyclization.

Herein, we report a facile synthetic methodol. for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chem. structures were confirmed by X-ray single-crystal diffraction anal. and the related data were provided. The plausible reaction mechanism studies are also discussed.

Catalysts published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Linbing published the artcileConversion of chenodeoxycholic acid to cholic acid by human CYP8B1, Related Products of nitriles-buliding-blocks, the main research area is chenodeoxycholic cholic acid human CYPB; S. pombe; bile acid; cytochrome P450; fission yeast; liver; steroid hydroxylation.

The human cytochrome P 450 enzyme CYP8B1 is a crucial regulator of the balance of cholic acid (CA) and chenodeoxycholic acid (CDCA) in the liver. It was previously shown to catalyze the conversion of 7α-hydroxycholest-4-en-3-one, a CDCA precursor, to 7α,12α-dihydroxycholest-4-en-3-one, which is an intermediate of CA biosynthesis. In this study we demonstrate that CYP8B1 can also convert CDCA itself to CA. We also show that five derivatives of luciferin are metabolized by CYP8B1 and established a rapid and convenient inhibitor test system. In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole and letrozole.

Biological Chemistry published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khajeh Dangolani, Soheila published the artcileImmobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS): An efficient catalyst for cyanation reaction in aqueous media, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is palladium nanoparticle cyclodextrin polyurethane nanosponge catalyst cyanation reaction.

Immobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS) were found to be an efficient heterogeneous catalyst in the cyanation reaction of aryl halides in aqueous media. This catalyst system is containing palladium nanoparticles with a size of � nm. Moreover, the CD-PU-NS support formed microsphere-shaped structures with a size of �00-200 nm. The TEM images show that Pd nanoparticles were formed in near spherical shape morphol. and were immobilized in the structure of the CD-PU-NS support. Under our optimized reaction conditions, aryl cyanides were obtained in high yields in the presence of the Pd-CD-PU-NS catalyst. Our results demonstrated that the Pd-CD-PU-NS catalyst is highly effective in the cyanation reaction in aqueous media. Furthermore, the catalyst could be simply extracted from the reaction mixture, providing an efficient methodol. for the synthesis of aryl cyanides. The Pd-CD-PU-NS catalyst could be recycled four times with almost consistent catalytic efficiency.

Inorganica Chimica Acta published new progress about Cyanation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Begum, Robina published the artcileReduction of nitroarenes catalyzed by microgel-stabilized silver nanoparticles, Related Products of nitriles-buliding-blocks, the main research area is nitroarene reduction microgel stabilized silver nanoparticle; Ag nanoparticles; Aryl amines; Catalytic reduction; Nitroarenes.

Poly(N-isopropylacrylamide-co-acrylamide) (PNA-BIS-2) microgels were synthesized by free radical precipitation polymerization in aqueous medium. Spherical Ag nanoparticles with diameter of 10-20 nm were fabricated inside the PNA-BIS-2 microgels by in-situ reduction of silver nitrate using sodium borohydride as reducing agent. The Ag nanoparticles- loaded hybrid microgels were characterized by SEM (SEM), Transmission electron microscopy (TEM), Energy dispersive X-ray (EDX), Scanning transmission electron microscopy (STEM), UV visible spectroscopy (UV Visible), Thermogravimetric anal. (TGA) and X-ray diffraction (XRD). Ag contents in the hybrid system were determined by inductively coupled plasma – optical emission spectrometry (ICP-OES). Various nitroarenes were successfully converted into their resp. aromatic amines with good to excellent yields (ranging from 75% to 97%) under mild reaction conditions. The catalyst has ability to successfully convert substituted nitroarenes into desired products keeping many functionalities intact. The catalyst can be stored for long time without any sign of aggregation and can be used multiple times without any significant loss in its catalytic activity.

Journal of Hazardous Materials published new progress about Microgels. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Fusheng published the artcileEfficient One Pot Capture and Conversion of CO2 into Quinazoline-2,4(1H,3H)-diones Using Triazolium-Based Ionic Liquids, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is CO quinazolinedione triazolium ionic liquid.

CO2 capture and utilization (CCU) have aroused much attention. In this paper, several novel triazolium-based ionic liquids (ILs) were developed for highly efficient transformation of CO2 into quinazoline-2,4(1H,3H)-diones. The catalytic behaviors such as the effects of IL structures and reaction parameters, catalyst recyclability, and scope of substrates were studied in detail. As compared to the reported homogeneous and heterogeneous catalysts, the [HTMG][Triz] with a tetramethylguanidine cation and a triazole anion exhibited an exceptional activity at 50°C and 1 atm CO2 without any organic solvents. On the basis of the CCU strategy, we first studied the equimolar CO2 capture by the [HTMG][Triz] and one pot conversion of activated CO2 into various quinazoline-2,4(1H,3H)-diones, and good to excellent product yields were obtained. In addition, the catalytic performance for synthesis of quinazoline-2,4(1H,3H)-dione under low concentration of CO2 using a simulated flue gas was studied. The developed triazolium-based ILs could realize simultaneous activation of CO2 and the substrates under ambient conditions, which also have been demonstrated to support the reaction mechanism well. The integrative protocol here shows great significance in the practical synthesis of quinazoline-2,4(1H,3H)-dione and their derivatives from captured CO2 waste under mild conditions. Triazolium-based ionic liquids show exceptional performance for equimolar CO2 capture and subsequent conversion into quinazoline-2,4(1H,3H)-diones under mild conditions.

ACS Sustainable Chemistry & Engineering published new progress about Flue gases. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts