185147-06-2, name is 3-Fluoro-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 185147-06-2
A solution of the compound 2A (50 g, 0.37 mol) in CCI4 (500 mL) was added the NBS (72.5 g, 0.408 mol) and the AIBN (1 .2 g, 0.037 mol), the reaction solution was refluxed for overnight, TLC indicated the reaction was completed, the reaction solution was filtered and concentrated in vacuum to give the crude product which was purified by flash silica chromatography eluting with petroleum ether/EtOAc (500:1 ) to give the desired compound 2B (30 g, yield: 40%) as a white solid.
The synthetic route of 185147-06-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; MARIGO, Mauro; KILBURN, John Paul; NIELSEN, Jacob; PUeSCHL, Ask; LANGGARD, Morten; JESSING, Mikkel; KEHLER, Jan; WO2013/45607; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts