Category: 17823-40-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4-Bromo-2,3,5,6-tetrafluorobenzonitrile

A mixture of Compound I (2.00 g, 4.59 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1 .19 g, 4.69 mmol), Pd(PPli3)4 (268 mg, 0.230 mmol), potassium carbonate (1.90 mg, 13.78 mmol) in degassed deionized water (6 mL) and degassed THF ( 18 mL) solution was stirred at 80 C under a nitrogen atmosphere for 18 h. After cooled to room temperature, the reaction mixture was filtered through a Ceiite pad rinsed by chloroform, and the resulting filtrate was evaporated in vacuo. The obtained residue was purified by column chromatography on silica gel using 3:2 (v/v) hexane/toluene as eluent to afford a white solid (0.962 g, 43.4%). HNMR (500 MHz, CDCb, d): 8.94 (d, J = 8 0 Hz, 1H), 8.86 (s, 1H), 8.77 (d, ./ = 8.0 Hz, 4H), 7.77 (f ./= 7.5 Hz, 1H), 7.70 (d, J= 7.5 Hz, 1H), 7 66-7 57 (m, 6H).

The synthetic route of 17823-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KYULUX, INC.; CHENG, Shuo-Hsien; CHO, Yong, Joo; SUZUKI, Yoshitake; YANG, Yu, Seok; NOTSUKA, Naoto; ENDO, Ayataka; KAKIZOE, Hayato; YOSHIZAKI, Makoto; AGUILERA-IPARRAGUIRRE, Jorge; (264 pag.)WO2019/191665; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17823-40-4 as follows. Quality Control of 4-Bromo-2,3,5,6-tetrafluorobenzonitrile

A mixture of Compound G (6 50 g, 14.93 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (3.86 g, 15.23 mmol), Pd(PPh3)4 (871 mg, 0.747 mmol), potassium carbonate (6 21 g, 44.79 mmol) in degassed deionized water (20 mL) and degassed THF (60 mL) solution was stirred at 80 C under a nitrogen atmosphere for 24 h. After cooled to room temperature, the reaction mixture was added methanol (400 mL) and filtered. The obtained solid was sequentially rinsed by water (20 mL) and methanol (20 mL), and eventually dried in vacuo. The obtained residue veas purified by column chromatography on silica gel using 3: 1 (v/v) hexane/toluene as eluent to afford a white solid (4 80 g, 66.6%). H NMR (500 MHz, CDCb, d): 8 94 (d, ./= 6.5 Hz, 2H), 8 80 (d, J= 7.0 Hz, 41 }. 7.70 (d, J= 8.5 Hz, 21 }. 7.66-7.59 (m, 6H); APCI-MS m/z: 483.4 ML

According to the analysis of related databases, 17823-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KYULUX, INC.; CHENG, Shuo-Hsien; CHO, Yong, Joo; SUZUKI, Yoshitake; YANG, Yu, Seok; NOTSUKA, Naoto; ENDO, Ayataka; KAKIZOE, Hayato; YOSHIZAKI, Makoto; AGUILERA-IPARRAGUIRRE, Jorge; (264 pag.)WO2019/191665; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, molecular formula is C7BrF4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 17823-40-4

1.14 cm3 of hydrazine monohydrate are added to 2.0 g of 4-bromo-2,3,5,6-tetrafluorobenzonitrile in 40 cm3 of absolute ethanol. The mixture is refluxed for 18 hours, 30 cm3 of distilled water are then added and the reaction medium is concentrated under reduced pressure (2 kPa; 50 C.). The residue is taken up in 100 cm3 of ethyl acetate and 10 cm3 of water, and the organic phase is separated out after settling of the phases has taken place, dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50 C.); after drying (90 Pa; 40 C.), 2.1 g of 6-bromo-4,5,7-trifluoro-1H-indazole-3-amine are obtained in the form of a beige-coloured solid. [0959] 1H NMR spectrum (300 MHz, (CD3)2SO-d6, delta in ppm): 5.52 (s: 2H); from 12.10 to 12.90 (broad unresolved peak: 1H). [TABLE-US-00076] EI m/z = 265M+. m/z = 236[M – HN2]+ m/z = 186[M – Br]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17823-40-4, its application will become more common.

Reference:
Patent; Dutruc-Rosset, Gilles; Lesuisse, Dominique; Rooney, Thomas; Halley, Franck; US2004/14802; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17823-40-4, Application In Synthesis of 4-Bromo-2,3,5,6-tetrafluorobenzonitrile

6-Bromo-3-amino-4,5,7-1H-indazole; A solution of 5 g of 4-bromo-2,3,5,6-tetrafluorobenzonitrile in 90 mL of ethanol is admixed with 9.7 mL of hydrazine hydrate. The reaction mixture is stirred for 17 hours at reflux and then concentrated under reduced pressure. The residue obtained is stirred for 30 minutes in 80 mL of distilled water. The suspended solid is isolated by filtration, washed with water, treated with suction and then triturated in 200 mL of ethyl ether and isolated by filtration, to give 1.03 g of 6-bromo-3-amino-4,5,7-1H-indazole, whose characteristics are as follows: MS spectrum (ES+): m/z=267 [MH+]

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Aventis Pharma S.A.; US2007/161626; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 17823-40-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17823-40-4 as follows.

A mixture of 2-ethynyl-1,3-dimethylbenzene (Compound 6) (0.4 g, 3.0 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (0.38 g, 1.5 mmol), Pd(PPh3)4 (0.173 g,0.15 mmol), Cul (0.057 g, 0.3 mmol) and diisopropylamine (0.4 g, 4 mmol) in dioxane (40 mL) was degassed and heated at about 80 C for about 16 hours. The resulting mixture was worked up with ethyl acetate. After filtered off precipitate, the solution was loaded on silica gel and purified by flash column using eluents of hexane to hexane/dichloromethane (4:1). Removal of solvent give a white solid (Compound 7) (0.4 g, in 88% yield).

According to the analysis of related databases, 17823-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 17823-40-4, These common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 4-cyanophenylboronic acid (1.83 g, 8 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1.0 g, 3.9 mmol), Pd2(dba)3 (0.18 g, 0.2 mmol), SPhos(0.16 g, 0.4 mmol) and K3PO4 (2.0 g, 8.7 mmol) in toluene (40 mL) was degassed and heated at about 120 C for about 16 hours. After cooled to room temperature, the mixture was filtered and washed with toluene. The filtrate was loaded on silica gel and purified by flash column using eluents of dichloromethane/hexane (10%to 40%). The desired fraction was collected and concentrated to give a white solid (Compound 10) (0.367 g, in 34% yield).

Statistics shows that 4-Bromo-2,3,5,6-tetrafluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 17823-40-4.

Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17823-40-4, Recommanded Product: 17823-40-4

A mixture of (1,2-dihydroacenaphthylen-5-yl)boronic acid (1.6 g, 8 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1.0 g, 3.9 mmol), Pd2(dba)3 (0.18 g, 0.20mmol), SPhos (0.16 g, 0.4 mmol), K3PO4 (2.0 g, 8.7 mmol) in toluene (50 mL) was degassed and heated at about 120 C for about 16 hours. After filtered off precipitate and washed with toluene, the filtrate was purified by flash column using eluents of hexane to hexane/dichloromethane (7:3). Removal of solvent give awhite solid (Compound 9) (0.54 g, in 42% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 17823-40-4,Some common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, molecular formula is C7BrF4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 4-bromo-2,3,5,6-tetrafluorobenzonitrile (2.2 g, 5.53 mmol), 2-cyanopyridine-5-boronic acid pinacol ester (2.0 g, 5.53 mmol), Pd2(dba)3 (0.18 g, 0.2 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (0.16 g, 0.4 mmol) and K3PO4 (2.2 g, 10 mmol) in anhydrous toluene (100 ml) was degassed and heated at 115 C for 16 hours. The resulting mixture was poured into ethyl acetate (100 ml), after filtered off precipitate, the solution was loaded on silica gel and purified by flash column using eluents of ethyl acetate/hexane (10% to 30%). The desired fractions were collected and concentrated to give white solid (Compound25) (0.18 g, in 6% yield).

The synthetic route of 17823-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

A mixture of 4-bromo-2,3,5,6-tetrafluorobenzonitrile (1 .5 g, 5.91 mmol), 3,5-bis(trifluoromethyl)phenylboronic acid (1.90 g, 7.38 mmol), Pd(PPh3)4 (0.341 g, 0.3 mmol) in toluene (70 ml) was degassed for about 1.5 hours with bubbling argon. Vacuum-oven-dried cesium carbonate (3.61 g, 1 1 .07 mmol) was added and the mixture was degassed for an additional 30 minutes and then heated to about 110 C for about about 64 hours. The resulting mixture was worked up with dichloromethane/brine, and the organic phase was collected and dried over MgS04. The crude mixture was purified twice by column chromatography on a silica gelcolumn using eluents of 0% to 3.5% ethyl acetate in hexanes, and then 5% to 30% dichloromethane in hexanes. The clean product fractions were dried by rotaryevaporation to yield Compound 21 (1.15 g, 51 % yield) as a clear crystalline solid.

The synthetic route of 4-Bromo-2,3,5,6-tetrafluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts