Category: 17626-40-3

Synthetic Route of 17626-40-3, These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of alkyne (0.2 mmol) in DMSO (2.0 mL) was added I2 (10.1 mg, 0.04 mmol). The solution was stirred at 130 oC for 24 h in air. Then the mixture was cooled to room temperature, and o-Phenylenediamine (0.3 mmol) was added. The solution was stirred at room temperature for 1 h. After completion, the solution was diluted with ethyl acetate, washed with H2O, dried over MgSO4, and concentrated in vacuo. The residue was purified by preparative thin-layer chromatography on silica gel with PE/EtOAc (15/1) as an eluent to give quinoxaline 3.

Statistics shows that 3,4-Diaminobenzonitrile is playing an increasingly important role. we look forward to future research findings about 17626-40-3.

Electric Literature of 17626-40-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17626-40-3, name is 3,4-Diaminobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of commercial o-phenylendiamines 1, 4-12 (1 mmol), 1-(4-formylpheny)-1H-benzimidazole (3) (1 mmol), and Na2S2O5 (1 mmol) in DMF (3 mL) was heated at 110-120C for 3 h.14 The reaction mixture was cooled, poured into H2O, and the solid was filtered. The residue was purified by column chromatography using chloroform/methanol (100:10) as eluant.

The chemical industry reduces the impact on the environment during synthesis 3,4-Diaminobenzonitrile. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,4-Diaminobenzonitrile

A 0.03 mol% Lewis acid-base bifunctional catalyst I (where Rf = CF3; R1, R2, R3, R4, R5, R6 = F) was added to a 100 mL single-mouth flask.0.2 mol of 4-fluoro-benzaldehyde (R7=4-F-C6H4), 0.1 mol of p-cyano o-phenylenediamine (R9=CN; R8, R10, R11=H), 15 mL of toluene, reacting at 25C Stir for 5 hours,TLC followed the reaction until the reaction was complete. The reaction results showed that the yield of product II (R7=4-F-C6H4; R9=CN; R8, R10, R11=H) was 94%; after repeated use of the catalyst system for 10 times, the catalytic performance did not decrease.

The synthetic route of 3,4-Diaminobenzonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 17626-40-3, name is 3,4-Diaminobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17626-40-3, Safety of 3,4-Diaminobenzonitrile

EXAMPLE 1A: 2-[l-(3-PHENYL-PYRAZrN-2-YL)-PIPERIDrN-4-YL]-lH- BENZOIMIDAZOLE-5-CARBOSTEP 1. TERT-BUTYL 4-(5-CYANO-lH-BENZO[D]IMIDAZOL-2-YL)PIPERIDTNE-l- CARBOXYLATE; [00186] To the solution of piperidine- 1 , 4-dicarboxylic acid mono-tert-butyl ester ( 15 g, 65.5 mmol) in DMF (50 niL) and pyridine (50 niL) was added CDI (10.6 g, 65.5 mmol) at 45 C and the mixture was stirred for another 2h at this temperature. Then 3, 4-diamino-benzonitrile (8.7 g, 65.5 mmol) was added and the mixture was stirred at RT overnight. Solvents were removed in vacuo and the residue was dissolved in HOAc (20 mL) and heated for lh at 100 C. Then the reaction mixture was concentrated and the residue was partitioned between DCM and aqueous of a2C03. The organic layer was dried over Na2S04 and concentrated to give the crude product which was purified by column chromatography (ethyl acetate: petroleum ether=l :2) to give the compound tert-butyl 4-(5-cyano-lH-benzo[d]imidazol-2-yl)piperidine-l-carboxylate (8 g, 65%) as pale solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Diaminobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; ANDREWS, Kristin L.; FROHN, Michael J.; HARRINGTON, Paul E.; PICKRELL, Alexander J.; RZASA, Robert M.; WO2011/143129; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 17626-40-3,Some common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, molecular formula is C7H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: 1H-benzo[d]imidazole-5-carbonitrile3, 4-Diaminobenzonitrile (1.0 g; 7.5 mmol) was dissolved in formic acid (3 ml_) and heated at 100C for 1.5 hours. The mixture was cooled, neutralised with 10% sodium hydroxide and the resulting precipitate isolated by filtration and dried in vacuo to yield the title compound as a brown solid (890 mg; 82%). 1H NMR (DMSO-de) delta 8.50 (1 H, s), 8.19 (1 H, s), 7.79 (1 H, d, J= 8.3 Hz), 7.62 (1 H, dd, J = 8.3, 1.54 Hz). LC/MS (Method C): 144 (M+H) HPLC (Method F) Rt = 2.14 min (Purity: 99.4%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Diaminobenzonitrile, its application will become more common.

Reference:
Patent; MERCK SERONO S.A.; WO2009/80663; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17626-40-3, name is 3,4-Diaminobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H7N3

General procedure: Ethyl-2-oxo-2-(6-phenylimidazo[2,1-b]thiazol-5-yl)acetate (4a,0.3 g, 0.9 mole) and O-phenylenediamine (5a, 0.108 g, 0.9 mole) were mixed properly and was charged into a specially designed microwave test tube and acetonitrile (5 mL) was added to this mixture and was irradiated for 35 min at 200C and 250 psi pressure. After cooling, the solid mass was crushed into 50 ml cold acetonitrile. The solid mass was filtered and the filtrate was discarded. After washing several time with cold acetonitrile, the solid mass was dried under vacuum to get the 3-(6-Phenylimidazo[2,1-b]thiazol-5-yl)quinoxalin-2(1H)-ones (6a). The related compounds (6b-q) were prepared in the same way

According to the analysis of related databases, 17626-40-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mukherjee, Chandrani; Watanabe, Kenneth T.; Biehl, Edward R.; Tetrahedron Letters; vol. 53; 45; (2012); p. 6008 – 6014;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 17626-40-3,Some common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, molecular formula is C7H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a screw-cap vial, the diamine or aminothiophenol (1 mmol) was dissolved in fluorinated carboxylic acid (2 mL, 0.5 M) and the reaction was stirred at 70 C for 16 hours. The fluorinated carboxylic acid was then evaporated under reduced pressure and the crude product was purified by silica gel column chromatography to yield the corresponding product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Diaminobenzonitrile, its application will become more common.

Reference:
Article; Rene, Olivier; Souverneva, Alexandra; Magnuson, Steven R.; Fauber, Benjamin P.; Tetrahedron Letters; vol. 54; 3; (2013); p. 201 – 204;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, molecular formula is C7H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 17626-40-3

Intermediate 44: (Trans)-N-(2-amino-5-cvanophenyl)-2-oxo-3-(2-pyridinyl)-1-oxa-3- azaspiro[4.51decane-8-carboxamide; To a shaken mixture of (trans)-2-oxo-3-(2-pyridinyl)-1-oxa-3-azaspiro[4.5]decane-8- carboxylic acid (Intermediate 45, 1 10 mg, 0.398 mmol) and 3,4-diaminobenzonitrile (commercially available, 80 mg, 0.597 mmol) in anhydrous pyridine (1.6 ml) was added EDCHCI (153 mg, 0.796 mmol) and the reaction mixture was shaken at room temperature for 1 hour. The mixture was concentrated under vacuum and the residue was partitioned between saturated sodium bicarbonate solution and EtOAc (2×10 ml). The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated under vacuum to give a residue which was purified by silica gel chromatography eluting with 40% Et2ODCM, Et2O 100% then 10% MeOHDCM to afford the title compound as solid (155 mg, 85%). 1 H-NMR (400 MHz, DMSO-d6): delta 1.59-1.79 (m, 4H), 1.93-2.02 (m, 2H), 2.03-2.10 (m, 2H), 4.03-4.07 (s, 2H), 5.92 (br s., 2H), 6.77 (d, 1 H), 7.13-7.18 (m, 1 H), 7.29 (d, 1 H), 7.62 (s, 1 H), 7.82-7.88 (m, 1 H), 8.1 1 (d, 1 H), 8.39 (d, 1 H), 9.09-9.16 (s, 1 H); UPLC-MS: 0.60 min, m/z 392 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17626-40-3, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/129007; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17626-40-3, name is 3,4-Diaminobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H7N3

General procedure: To a methanolic solution of the hydrogenated product 1 (0.40 g, 3.06 mmol), equivalent amount of 2,4-difluorobenzaldehyde (0.44 mL, 3.06 mmol) and half equivalent of aqueous solution of Na2S2O5 (0.29 g, 1.53 mmol in 3 mL H2O) were added. The resulting solution was stirred at reflux for 5 h, and filtered through a bed of Celite. The filtrate was concentrated under reduced pressure and residue was purified by column chromatography (eluent pet. ether/EtOAc, 7:3). The pure product was isolated as a solid (0.46 g, 1.83 mmol 65% yield)

The synthetic route of 17626-40-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Manish; Tandon, Vibha; European Journal of Medicinal Chemistry; vol. 46; 2; (2011); p. 659 – 669;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

17626-40-3, name is 3,4-Diaminobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 17626-40-3

A solution of 1 (557.5 mg, 2.5 mmol), 3, 4-diaminobenzonitrile (332.5 mg, 2.5 mmol), and benzoquinone (270.2 mg, 2.5 mmol) in ethanol (40 mL) was allowed to reflux under nitrogen for overnight. The reaction mixture was distilled off under reduced pressure. The residue was triturated with ether and filtered off to afford 2 in 90%, mp >340 C.’H NMR (DMSO-d6) ; J 7.20 (d, J = 8.4 Hz, 1 H), 7.68 (d, J = 8.4 Hz, 1 H), 7.86-7. 98 (m, 6H), 8.28 (s, 1 H), 8.57 (s, 1H), 12.80 (brs, 1H), 13.65 (brs, 1H). 13C NMR ; No. 158. 4, 153. 9,143. 5,132. 9, 131.0, 129.3, 126.7, 125.7, 119.7, 118.9, 118.1, 112.8, 109.4, 104.5. MS (m/z, rel. int. ); 336 (M+, 100), 307 (25), 280 (5), 164 (10). High resolution calcd. for C21H12N4O ms 336. 10111. Observed 336.10189. Anal. (C21H12N4O-0.25H2O) C, H, N.

Statistics shows that 17626-40-3 is playing an increasingly important role. we look forward to future research findings about 3,4-Diaminobenzonitrile.

Reference:
Patent; UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.; WO2005/40132; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts